Biomedical subjects
Publications and source records attributed to G Olesnicky.
The histological changes relating to 2 separate artificial hormone replacement implants in a 34 yr old female are presented. Both sites essentially showed a predominant lymphohistiocytic reaction with fibrosis. One implant was intact while the other had disintegrated.
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A retrospective study was made of 455 patients referred to the Hydatidiform Mole Register of the Royal Women's Hospital from 1973-1982 who fulfilled the criteria for diagnosis of hydatidiform mole. The incidence of hydatidiform mole was 1:1,357 livebirths in Victoria. Age greater than 40 years (P less than 0.001), nulliparity (P less than 0.005) and parity greater than 4 (P less than 0.001) were the only predisposing factors found. An association with artificial insemination with donor semen was also noted (P less than 0.025). The need for further treatment for persistent trophoblastic activity (13.6% of patients) was independent of the method of evacuation employed and of gestation at evacuation. Only 2 cases of histologically proven postmolar choriocarcinoma occurred, one of which was also the only death recorded from all patients registered following a molar pregnancy.
In a retrospective study of 455 patients with confirmed molar pregnancy, registered with the Hydatidiform Mole Register of the State of Victoria in the years 1973-1982 inclusive, treatment for persistent trophoblastic activity was necessary in 62 (13.6%) patients. The need for treatment was independent of levels of urinary chorionic gonadotrophin (UCG) excretion prior to evacuation of the molar pregnancy, age, parity or blood group. All patients achieved initial remission of UCG levels within 5 courses of treatment. Risk factors were scored retrospectively and patients responded poorly if therapy inappropriate to risk factors was given. Only 2 cases of histologically proven choriocarcinoma occurred and the only death recorded was in 1 of these patients.
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