PubMed Health⌕ Search

Biomedical subjects

G Olsson

Publications and source records attributed to G Olsson.

At least 145 records · Page 8Linked to original sources
PubMed1981

Metoprolol treatment after acute myocardial infarction. Effects on ventricular arrhythmias and exercise tests during 6 months.

One hundred and six patients on double-blind treatment with placebo or metoprolol, 100 mg b.i.d., during the first 6 months after an acute myocardial infarction were investigated. The patients were stratified and randomized to treatment according to type of ventricular arrhythmias on a six-hour ECG registration, size of infarct estimated by enzyme maximum and age. During the follow-up period, a further three six-hour ECG recordings and three exercise tests were performed. In the metoprolol group the incidence of malignant ventricular ectopic beats decreased significantly (p less than 0.05) after three days' treatment. This decrease lasted for one month but was not observed at the six-month registration. No difference in working capacity was seen between the two groups, nor were there any differences in ischemic ST depressions on ECG during exercise. The proportion of patients terminating exercise because of angina pectoris was similar, but significantly more patients in the metoprolol group (p less than 0.05) discontinued exercise at six months because of fatigue. Large heart volumes were observed somewhat more often in the metoprolol group but there was no extended need of treatment for cardiac failure.

Adult↗
PubMed1980

Studies on the effect of treatment with anthelmintics on weight gain in calves, naturally infected with gastrointestinal nematodes.

To avoid disease outbreaks caused by gastro-intestinal nematodes different prophylactic measures are recommended. In this connection pasture hygienic achievements and anthelmintics are used. In practice it is often difficult to realize pasture hygienic steps as move the animals to parasite free areas and to avoid that they come back to the infected. In many cases the parasite control is limited to routine deworming. Our intention was to study if anthelmintic treatment without other measures had any effect on weight gain and number of eggs in faeces in calves naturally infected with Ostertagia ostertagi. The studies were done during two stable seasons 1975/76 and 1976/77 when the calves were treated two weeks after stabling, and during two grazing seasons 1976 and 1977 when the calves were treated 20 days or 15 and 20 days after turning out. In none of the trials any obvious influence on the weight gain and number of eggs was observed. The failing effect during the stable season might depend on the fact that the parasites to more than 90% were in inhibited L4-stage, and the failing effect during grazing, is surely an effect of reinfection when the calves remain on the infected pastures. As prophylactic measure anthelmintic treatment is of very little value if not the calves at the same time are protected against reinfection by moving to clean pastures.

Animals↗
PubMed1977

On the rise in low density and high density lipoproteins in response to the treatment of hypertriglyceridaemias in type IV and type V hyperlipoproteinaemias.

In Type V hyperlipoproteinaemia the concentration of LDL and HDL cholesterol is low. When the hypertriglyceridaemia is normalized, either by diet or micotinic acid, both LDL and HDL increase. In Type IV hyperlipoproteinaemia both LDL and HDL cholesterol decrease with increasing VLDL levels. During treatment of Type IV the change in LDL cholesterol is linearly related to the pretreatment LDL concentration so that higher LDL levels will fall and the lower will rise. HDL levels will also rise. The fall in VLDL during treatment is rapid and the rise in LDL also occurs rapidly indicating a relationship between these two reciprocal changes. HDL cholesterol, however, however, remains constant some time after VLDL has reached its lowest level and the rise occurs later indicating another mechanism than for LDL. These changes in the three major lipoprotein classes deserve clinical attention. While both the fall in VLDL and the rise in HDL may be benefical from the point of view of atherosclerosis the rise in LDL may be harmful. These is at present no way to evaluate the effect of these complex changes. However, these findings stress the imporance of considering changes in lipoprotein levels and not only in total serum triglycerides and cholesterol during treatment of hyperlipoproteinaemia.

Cholesterol↗
PubMed1975

A radiographic method for assessing changes in alveolar bone height following periodontal therapy.

A method is described for obtaining reproducible radiographs of several groups of teeth in the same jaw. The method was applied to assess changes in the alveolar bone height following periodontal treatment. An oral device was designed to permit direction of the central rays of the beam perpendicularly to the alveolar process in different parts of the jaws. The exposures were made at 60 kVp and 10mA, and standardized procedures were used for developing, fixing and rinsing the films. Alterations in the marginal alveolar bone level were determined in a stereocomparator system. The reproducibility of the method was determined. A pilot experiment was performed on 5 patients with periodontal disease. Following conservative treatment, including scaling and root planning, all patients were subjected to periodontal surgery, including alveolar bone denudation. Radiographs of the alveolar bone were obtained before and 2 months after the operation. By measuring in the stereocomparator parallaxes of both control points and points of the alveolar bone crest on paired radiographs, a mean decrease in interproximal alveolar bone height of 0.69 mm was found. Taking into account the small errors which are inherent in the method, this change in bone height could be regarded as a reliable measure of actual loss of bone.

Adult↗
PubMedDate not supplied

Does cardiovascular reactivity to mental stress have prognostic value in postinfarction patients? A pilot study.

The possible relationship between mental stress-induced cardiovascular reactivity and clinical prognosis was examined in a pilot study of 13 postinfarction patients. All patients had previously participated in the placebo condition of a secondary intervention trial. On completion of the trial, blood pressure, heart rate, and venous plasma catecholamines were evaluated at rest and in response to a modified Stroop test on two occasions. At follow-up 39 to 64 months later, five patients had suffered a new clinical event (reinfarction and/or stroke). These patients had shown significantly larger systolic and diastolic blood pressure responses to the Stroop test than had patients who remained event-free at follow-up. Catecholamine concentrations also differed between groups during mental stress, but on only one of the two test days. Groups did not differ on baseline measurements, cardiovascular response to exercise testing, fasting serum lipid and glucose concentrations, age, or duration of follow-up.

Blood Pressure↗
PubMedDate not supplied

Immunohistochemical detection of macrophages and T lymphocytes in atherosclerotic lesions of cholesterol-fed rabbits.

Human atherosclerotic plaques contain significant numbers of T lymphocytes and monocyte-derived macrophages. Cytokines released from activated T lymphocytes induce aberrant expression of major histocompatibility complex class II (Ia) antigens by vascular smooth muscle cells and may also regulate cell proliferation and metabolism in the vessel wall. We have analyzed the arteries of cholesterol-fed rabbits to study the sequence of lymphocyte and monocyte entry into the forming atherosclerotic lesion. Rabbits were fed 0.3% cholesterol for 1-10 weeks, and monoclonal antibodies to rabbit leukocyte differentiation antigens and Ia antigen were applied to sections of the aorta. Monocytes were already observed 1 week after initiation of cholesterol feeding, and they accumulated in the intima, where they formed the bulk of the foam cell-rich lesion. T lymphocytes also adhered to the aortic surface from 1 week onward, and also accumulated in the lesion, although in lower proportions than did monocytes. In 10-week lesions, approximately 6% of cells expressed the T-lymphocyte marker L11/135. Ia antigen expression was frequent throughout the lesion in all phases of its development, and most of the Ia-expressing cells could be identified as monocyte-derived macrophages. These data indicate that the cholesterol-fed rabbit is a useful model for studying the role of monocytes and T lymphocytes in atherosclerosis.

Animals↗