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Biomedical subjects

G Oppenheim

Publications and source records attributed to G Oppenheim.

26 records · Page 2Linked to original sources
PubMed1983

[Parkinson's disease and mental deterioration. Apropos of 30 cases].

The influence of Parkinson illness on intellectual faculties is appreciated in different ways. The existence of a real parkinson dementia is contested by some who see in the intellectual impoverishment of these patients a simple decline in efficiency. This is often partial and linked to neurological consequences which are not always taken into account by psychometric tests. 30 parkinson patients are beeing examined in this light. In spite of the small number, quite clear tendencies are apparent and which confirm the possible existence of these two types of phenomena, one beeing dementia and the other simply weakness without authentic senility. Risk factors are also isolated which emphasize age and accidents due to L-Dopa intolerance.

Adult↗
PubMed1982

Physical illness diagnosed as psychiatric: patients at special risk.

Recent research has further confirmed the significant incidence of undiagnosed physical illness in patients presenting psychiatric symptoms. Such research has generally involved psychiatric inpatient or outpatient populations. As a liaison psychiatrist in a general hospital, the author defines two especially high-risk groups for such missed diagnoses and emphasizes the fact that psychiatric symptoms are not illness specific. An approach to the clinical evaluation of such patients is discussed, mentioning the inherent medicolegal implications.

Adult↗
PubMed1982

Drug-induced rapid cycling: possible outcomes and management.

Rapid cycling of mood change induced by antidepressant drugs has recently emerged as a significant diagnostic and therapeutic problem. The author describes two additional cases. Cessation of treatment with the offending drug may leave the patient depressed, manic, or euthymic or in a state of continued rapid cycling. The author suggests an approach to management of this condition.

Adult↗
PubMedDate not supplied

The earliest signs of Alzheimer's disease.

Insufficient clarity of definition of the clinical features in the earliest stages of developing Alzheimer's disease (AD) has impeded the execution of clinical and biologic studies into this major public health problem. Defining the earliest signs of a disease with such an insidious onset can prove to be a most elusive task, particularly in a disease whose very nature renders the patients' self-report unreliable. We therefore administered a structured interview to the close family caregivers of 83 patients with probable AD, in order to investigate the earliest perceived signs of illness in the patients. In 44 (53%) of patients, the earliest objective sign of change was not memory impairment. The initial sign of change was of a psychiatric type in 27 (32.5%); of a neurologic type in nine (10.9%); and of a noncoping type in eight (9.6%). Such nonmemory signs, as perceived by caregivers, preceded objective memory impairment by a mean of 1.8 years. In 39 patients (47%), memory impairment was the initial perceived sign of illness. These findings suggest that the earliest clinical manifestations of AD may, in many cases, significantly predate objective signs of memory impairment.

Aged↗
PubMedDate not supplied

[Acute psychoses and mood disorders in Parkinson disease. Role of antiparkinson therapy].

L-DOPA has progressively replaced atropinic substances in the treatment of the Parkinson's disease but its superiority is not evident in all domains. The same as these substances, it can occasion a secondary psychical pathology essentially presented by affective disorders and psychotic phenomena. The proposed study lays on the comparison between two parkinsonian groups, one undergoing a dopaminergic treatment the other one not. The hallucinary and confusing properties and to a lesser degree the depressive properties of L-DOPA are correlated to risk factors amongst which the average advanced age of the patients has the greatest place.

Acute Disease↗