Biomedical subjects

G Orndahl

Publications and source records attributed to G Orndahl.

At least 19 recordsLinked to original sources

PubMed1988

Muscle function and morphology in myotonic dystrophy.

Patients with myotonic dystrophy classified clinically into function groups were studied. Muscle strength for knee extension and flexion was, with few exceptions, moderately or markedly reduced with successively more severe clinical disability. The reduction in maximal walking speed showed a similar tendency. There was a large percentage of both type I and in relation to normal findings of type II C fibers in biopsies from most patients. The fiber area varied greatly even in the patients in the best function groups, some of whom had large type II fibers. The most common-histopathological changes, found in all function groups, were fiber atrophy with small angular fibers, internal nuclei, splitting, fibrosis and moth-eaten fibers. A high percentage of type I fibers can already be seen in patients with practically no other morphological changes and without significant functional deterioration.

Adult↗

PubMed1987

Eye motility dysfunction in chronic primary fibromyalgia with dysesthesia.

Thirty-six patients with "chronic primary fibromyalgia" combined with dysesthesia were studied using oculomotor tests. The test results were compared with those of a control group consisting of 71 healthy persons. The saccades were found to be abnormal in 42% of the patients studied. The maximum velocity of the saccades was often reduced, while the accuracy was normal. The smooth pursuit eye movements were deranged in 89% of the patients. The velocity gain was reduced and the number of corrective saccades was increased. The results indicate that brain dysfunction, often at the brainstem level, is commonly seen in patients with chronic primary fibromyalgia syndrome combined with dysesthesia.

Adult↗

PubMed1987

Neuroaudiological findings in chronic primary fibromyalgia with dysesthesia.

Thirty-six patients (31 females and 5 males) with "chronic primary fibromyalgia" combined with dysesthesia were studied using neuroaudiological tests. Auditory brainstem response (ABR) was pathological in 11 patients (31%). In six instances the I-V interpeak latency (IPL) was prolonged, in two instances the interaural difference of wave V (IT5) was pathological, and in three instances there was a reduction of the amplitude of wave V. A comparison of the I-V IPLs between the female patient group and a matching control group showed that there was a significant prolongation of this parameter in the patient group. The ABR-findings indicate that a brainstem dysfunction might be present in some patients with fibromyalgia. The results of the impedance audiometric tests were generally normal in the patient group.

Acoustic Impedance Tests↗

PubMed1986

Myotonic dystrophy treated with selenium and vitamin E.

We have previously reported the successful treatment of a patient with myotonic dystrophy with selenium and vitamin E. This paper deals with the treatment of a further five patients with myotonic dystrophy in different stages. All five patients improved subjectively and objectively in two or more respects. All improved their grip strength according to vigorimeter measurements (Martin), two normalized their gait, another two can now sit down on their heels and stand up, one patient can now walk on his toes, one can now get up from lying on the floor without using a chair and two patients have improved their physical capacity. Patients in early stages of the disease improved faster and more markedly than those in late stages. Electromyographical measurements also showed improvements, in that the myotonic discharges had diminished. The daily dose was 4 mg of Na2SeO3 and 600 mg of vitamin E. Serum concentration of selenium increased in all patients at the beginning of the treatment, but stabilized at a level slightly above the normal. No side-effects were observed.

Adult↗

PubMed1975

Adipose tissue cellularity in relation to metabolism in juvenile onset diabetes mellitus.

Adipose tissue cellularity was determined by a microscopic method in 18 men suffering from insulin dependent, juvenile diabetes mellitus for several years. These results were set in relation to the degree of clinical control estimated from the average urinary glucose output or fasting blood glucose during the year preceding the investigation. Furthermore, the results were compared with controls of comparable age and of the same sex. Both young and middleaged diabetic men had smaller fat cells than non-diabetic men. Fat cell size was correlated to the degree of clinical control, small fat cells indicating a poor control. It was suggested that fat cell size might be included as a measure of the long-term metabolic control in patients with insulin dependent diabetes mellitus.

Adipose Tissue↗

PubMed1973