Biomedical subjects

G Osterburg

Publications and source records attributed to G Osterburg.

4 recordsLinked to original sources

PubMed1982

Computer programs for the analysis and the management of DNA sequences.

A program package is described for the management and the analysis of DNA sequence data. The programs - with the exception of a few Fortran routines - are written in the programming language APL. They are best used interactively although batch processing is possible. The package has been in constant use for about 3 years and contains programs for most of the routine problems presently found in a DNA sequencing laboratory.

Amino Acid Sequence↗

PubMed1978

Nucleotide sequence of bacteriophage fd DNA.

The sequence of the 6,408 nucleotides of bacteriophage fd DNA has been determined. This allows to deduce the exact organisation of the filamentous phage genome and provides easy access to DNA segments of known structure and function.

Base Sequence↗

PubMedDate not supplied

Computer support of DNA sequence analysis.

The paper describes a package of APL-programs suited for the management and the analysis of DNA sequence data. Most of the application programs are related to experimental work in a DNA sequencing laboratory: Search for overlapping DNA fragments to construct complete DNA sequences; search for restriction sites; computing fragment patterns when cutting a DNA with restriction enzymes; plotting physical and genetic maps of a DNA; search for homologies as well as various counting procedures. More sophisticated programs are concerned with the prediction of RNA secondary structure and its graphical representation.

Base Sequence↗

PubMedDate not supplied

A fast method for arranging DNA sequence fragments.

A method is described which allows efficient arrangement of DNA sequence fragments and, based on this arrangement, reconstruction of a complete DNA sequence. The concepts and algorithms used are based on the mathematical theory of graphs. The amount of human interaction required is considerably reduced compared to existing methods. An experiment with a set of 168 fragments yields a DNA sequence of about 5800 bases almost automatically.

Base Sequence↗