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Biomedical subjects

G P Filippov

Publications and source records attributed to G P Filippov.

At least 19 recordsLinked to original sources

[Experience with non-drug correction of autonomic disorders in adolescents].

The efficiency of recovery of autonomic imbalance by auricular electric neurostimulation (AENS) was studied. Thirty-nine children aged 11 to 15 years who had been diagnosed as having vegetative dystonia were divided into 2 groups: Group 1 (n = 18) received therapy with AENS; Group 2 (a control group) (n = 21) had the standard drug therapy. The study has indicated that AENS is more effectively than the standard therapy. In Group 1, clinical symptoms began ameliorating more early than in Group 2. According to instrumental data, positive changes were recorded in all the children in Group 1 and only in 57.2% in Group 2. It is concluded that it is expedient to use AENS to correct autonomic imbalance.

Adolescent↗

[The activity of superoxide dismutase and glutathione peroxidase and the level of malonic dialdehyde in prematures with hypoxic disorders of the central nervous system].

The activity of superoxide dismutase and glutathione peroxidase and the level of malonic dialdehyde were studied 53 prematures with hypoxia of the central nervous system. A low activity of superoxide dismutase and glutathione peroxidase, which depended on a prematurity degree and on a content of malonic dialdehyde in the erythrocyte cell membranes, was found. A higher level of malonic dialdehyde in erythrocyte membranes was shown to be an unfavorable prognostication factor for the development of intraventricular hemorrhages in prematures.

Central Nervous System↗

[Lipids of lymphocyte plasma membranes in patients with atherosclerosis and their children].

Phospholipid composition and activity of 5'nucleotidase of lymphocyte plasmatic membranes were studied in patients with atherosclerosis (AS) and their children. The content of phosphatidylcholine, cholesterol/total phospholipid ratio, transmembrane asymmetry of lipids were increased, 5'nucleotidase activity decreased, and lymphocyte plasmatic membranes contained accumulations of lisophospholipids (LPL). This indicated increased hydrophobia and decreased functional activity and damage of lymphocyte plasmatic membranes. Increased transmembrane lipid asymmetry and LPL accumulations were detected in the lymphocyte plasmatic membranes of children with aggravated heredity for AS. Presumably these disorders anticipate the changes in the structure of plasmatic membranes, observed in adult patients with AS, and progress in case of exposure to unfavorable factors.

5'-Nucleotidase↗

[Reversible red cell aggregation in children with insulin-dependent diabetes mellitus].

Red cell aggregation has been studied by photometry in 47 children with insulin-dependent diabetes mellitus. The disease was associated with boosting of reversible red cell aggregation, which was most of all expressed during metabolic decompensation with ketoacidosis. When metabolic subcompensation was attained, this parameter did not completely normalize and still had to be corrected.

Adolescent↗

[Features of surface architectonics and ultrastructure of peripheral blood in children with insulin-dependent diabetes mellitus].

Electron microscopic study of the surface architectonics and ultrastructure of the peripheral blood erythrocytes in 25 children with insulin-dependent diabetes mellitus (IDDM) revealed that the decrease of the count of disk-shaped cells, increased count of transitional and degenerative forms, and alteration of their ultrastructure. Traditional therapy failed to completely normalized these characteristics over the entire follow-up.

Age Factors↗

[Ontogenetic peculiarities of hemostasis in newborn children].

A total of 25 newborns (15 full-term and 10 preterm babies) were examined. The coagulative and summary lytic blood activity with regard for the aggregategram and hemocoagulagram findings was studied. The following was established: the neonatal period of healthy babies is characterized by changing stages in the hemostasis system, i.e. hypocoagulation is followed by the normalized coagulation fibrinolytic activity. Preterm babies have more pronounced changes and become normal later.

Blood Coagulation Tests↗

[Changes in erythrocyte superoxide dismutase and catalase activity in premature newborns with intraventricular haemorrhages].

Superoxide dismutase and catalase activities have been studied in peripherical blood erythrocytes of 49 premature newborns at 28-37 weeks gestation. Superoxide dismutase and catalase activities were lower in patients with bacterial infection of meninges. The standard therapy did not restore superoxide dismutase and catalase activities by the end of the neonatal period.

Catalase↗