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Biomedical subjects

G P Graham

Publications and source records attributed to G P Graham.

At least 19 recordsLinked to original sources

Recurrent dislocation of the hip in adult paraplegics.

Recurrent dislocation of the hip is rare and has not previously been reported in adult paraplegics. This paper describes 3 cases. In one patient it was spontaneous, occurring 16 years after the original injury and was associated with a flexion-adduction contracture of the hip and a shallow acetabulum. One case occurred after minor trauma in a patient who experienced flexion-adduction spasms of the hip. In the third patient the condition was secondary to posterior acetabular deficiency following a conservatively treated fracture dislocation. All 3 patients experienced symptoms of disabling autonomic dysreflexia during the episodes of dislocation. The importance of recognising and adequately treating hip injuries in patients presenting with paraplegia secondary to spinal cord injury is stressed. In patients with spastic paraplegia presenting with recurrent dislocation of the hip, operative treatment combining a soft tissue repair and a bone block to augment the acetabulum is recommended.

Adult

Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms.

Inflammatory cells often are seen in the walls of human aortic aneurysms, but their significance is uncertain. To investigate their actions an in vivo model of arterial aneurysms was developed in the rat. Fifteen units of hog pancreatic elastase were infused for 2 hours into the isolated abdominal aorta in 26 rats. The vessels were measured in vivo and were excised for conventional histologic and immunohistologic study at selected intervals. In untreated control rats the diameter of the aorta was 1.04 +/- 0.02 mm. Immediately after infusion with elastase the aorta dilated 26% to 1.31 +/- 0.02 mm (p = NS), with no histologically demonstrable remaining elastic lamellae. Two and one half days after infusion the aorta dilated nearly 300% to 3.09 +/- 0.08 mm (p less than 0.05). These vessels exhibited large numbers of activated macrophages and T cells in the media. Three and 4 days after infusion the vessels dilated 388% to 4.04 +/- 0.09 mm and 367% to 3.82 +/- 0.31 mm, respectively. These vessels also exhibited numerous inflammatory cells in the media. Six days after infusion the vessels enlarged 421% to 4.38 +/- 0.03 mm (p less than 0.05), and the infiltrate persisted staining immunohistologically for macrophages, polymorphic neutrophils, and T lymphocytes. Twelve days after infusion the aneurysms remained enlarged but stable at 4.23 +/- 0.14 mm (p = NS). At this time the number of inflammatory cells regressed to control levels. The temporal correlation between inflammatory infiltrate and aneurysmal enlargement suggests that inflammatory cells may participate in the destruction of the aneurysmal vessel wall thereby promoting progressive enlargement.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance

Dillwyn Evans operation for relapsed club foot. Long-term results.

We reviewed the long-term results of the Dillwyn Evans procedure for club foot in 60 feet of 45 patients with an average age of 29 years, using four different scoring systems. The results at 12 to 38 years were compared with those of an earlier study of the same group of patients. Function was satisfactory in 68% of feet; 90% of the patients were able to perform all desired activities. Mild residual deformity was compatible with satisfactory function, and poor function was related to ankle and subtalar stiffness. Our results suggest that this procedure has a low rate of deterioration and degenerative change with time.

Activities of Daily Living

A solution for arthroscope misting.

A prospective study was undertaken to compare the incidence of arthroscope eyepiece misting in two groups of patients. In one group the irrigation fluid was at room temperature and in the other group the fluid was warmed to body temperature. Arthroscope eyepiece misting was eliminated when irrigation fluid at body temperature was used.

Arthroscopes

Comparison of clinical tests and the KT1000 in the diagnosis of anterior cruciate ligament rupture.

A prospective study was undertaken to compare the accuracy of the Lachman test, anterior drawer test and jerk test with the KT1000 knee arthrometer in patients with proven anterior cruciate ligament deficiency. The Lachman and anterior drawer tests were found to be the most accurate indicators of anterior cruciate ligament deficiency. The KT1000 knee arthrometer was found to be totally inaccurate, which precludes its use as an objective measure of anteroposterior laxity of the knee.

Anterior Cruciate Ligament Injuries

Preparation of skin for surgery.

A survey of 113 hospitals in the UK was performed to assess current practices regarding skin preparation for surgery. The findings of the survey are presented and where relevant compared with a similar survey conducted in 1983. It was found that, despite scientific evidence supporting change, traditional practices still dominate. This evidence is discussed and, based on this, some changes in practice are suggested.

Dermatologic Surgical Procedures

Radiological sign of chronic anterior cruciate ligament deficiency.

An early radiological sign of anterior cruciate ligament deficiency is described. A retrospective study of the radiographs of 38 patients with chronic anterior cruciate ligament deficiency was performed. In 36 patients from this group an osteophyte was present on the medial femoral condyle adjacent to the medial tibial spine. This was best seen on a 30 degree notch view and was the earliest radiographic sign of chronic anterior cruciate ligament deficiency.

Anterior Cruciate Ligament

Local or general anaesthetic in day case arthroscopy?

A series of 66 patients who have undergone arthroscopy of the knee using three local anesthetic techniques is presented. Over a similar period of time 70 patients had knee arthroscopy performed under general anaesthesia. In the local anaesthetic group the technique was successful in 50 cases, partially successful in 12 cases and totally unsatisfactory in 4 cases. In the general anaesthetic group all the procedures were successful. Local anaesthetic techniques were found to be satisfactory for diagnostic arthroscopy but general anaesthesia was better for operative procedures and was more acceptable to the surgeon and patient.

Ambulatory Surgical Procedures

Early osteoarthritis in young sportsmen with severe anterolateral instability of the knee.

In a retrospective study of patients presenting with symptoms of knee instability, 16 patients were discovered who had developed severe chondromalacia or osteoarthritis of the femoral condyles. All of the patients gave a history of a previous severe knee injury occurring in their teenage years and all had continued to play competitive sport. Ten of the group had subsequent meniscal injuries requiring surgery. In nine of the group previous arthroscopic or open joint procedures had demonstrated normal femoral joint cartilage. There was no difference in the degree of degeneration in those who had had a meniscectomy as compared with those who had not had meniscal damage. It is concluded that severe anterolateral instability is a cause of early degenerative joint disease in young athletes even in the absence of meniscal damage and that they should be strongly advised against participating in active sport until the joint has been stabilized.

Adult

Experience with the A.O. locking femoral nail.

A series of 21 fractures of the femur unsuitable for ordinary closed nailing have been treated using the A.O. locking femoral nail. The results obtained have been good with one case of non-union and no cases of deep infection, despite the complex nature of the fractures. The procedure is technically demanding and exposes the surgeon to the risks of ionizing radiation. Practical points to simplify the procedure and reduce exposure to radiation are discussed.

Adolescent

New problems in old bones: closed nailing of the shaft of the femur.

Closed medullary nailing is now established as a routine treatment of fractures of the shaft of the femur. However, the quality of the bone in elderly patients is such that serious technical difficulties may arise during the operation. Three typical cases illustrate the problems that may occur and point the lesson that closed nailing in the elderly ought not to be undertaken by the inexperienced surgeon.

Aged

Primary oat cell carcinoma of the oesophagus.

Three cases of oat cell carcinoma of the oesophagus are presented and published reports reviewed. This is mainly a disease of older age with a 3:2 predominance of men. Of all published cases, 43 (47.3%) occurred in the middle third, 41 (45.1%) in the lower third, and four (4.4%) in the upper third. In one case it was multifocal and in two the location was not stated. Dysphagia was the most common symptom and was found in 82.5% of cases. Overall survival was 4.7 months. The longest survival in a patient treated by resection was 24 months and in a patient treated by chemotherapy 11 months. All but one of the patients had widely disseminated metastatic disease at death. It is concluded that surgery, possibly with adjuvant chemotherapy, holds out the best prospect for such patients.

Aged