Biomedical subjects
Publications and source records attributed to G P Kondratenko.
To treat patients with the post-injection abscess and mastitis, suspension of alveolar porcine macrophages was periodically introduced via a drainage tube into the cavity formed after sparing opening of an abscess and removal of necrotic tissues. Local use of the substance permitted to shorten by 30-50% the duration of hospital stay of the patients as compared to that in use of conventional methods.
The decisive factor in the appearance of postinfection abscesses is the presence of damaged tissues, open to the penetration of microorganisms not only by the exogenic or endogenic route, but also by the so-called exoendogenic route, when they penetrate the body from the air via the upper respiratory ways and further into the blood and damaged tissues.
Quantitative microbiological examinations of the sputum allowed to establish the role of pneumococci and different bacterial associations in the development of acute pneumonia. The most typical were associations of Str. pneumoniae, staphylococci and neisseriae. The sensitivity of isolated pathogens is shown and recommendations on the use of most effective antibiotics are given. The indications to immunocorrective agents are outlined.
Sputum samples obtained from 106 patients with acute pneumonia have been studied by the quantitative microbiological method. Different microbial associations have been shown to play an important role in the development of acute pneumonia (67.9%). Microbiological studies have revealed the prevalence of pneumococci in the etiological structure of the disease. Staphylococci, hemophilic bacteria and Neisseria have been found to take part in the development of acute pneumonia in a lesser number of cases and more often occur in combination with pneumococci or form different associations themselves. The so-called "etiological" type of microbial associations has been determined, two or three microbial species being isolated at high concentrations (10(6) and over) and the percentage of patients with such combinations being 59.7 +/- 5.8%. The analysis of the clinical course of the disease has revealed that the presence of different microbial species in patients linked, to a great extent, with the clinical picture of the disease. These data may be used for prescribing adequate etiotropic therapy and for prognostication. Quantitative bacteriological studies carried out in the dynamics of the disease permit timely detection of changes in the microflora of the respiratory tracts, the evaluation of the effectiveness of antibacterial therapy in the process of its implementation and the rational correction of therapeutic measures.
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The paper is concerned with the results of quantitative studies on the sputum of 106 patients with acute pneumonia. Etiological structure of acute pneumonia, the dependence of a clinical course of disease on a sputum microflora composition type and some indices of natural resistance and immunity were shown.
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In this work the data obtained in the quantitative investigations of sputum samples from 106 miners having acute pneumonia are presented. These investigations were carried out twice at the peak of the disease to determine the possible infective agent. The virological study of nasal impression smears by immunofluorescence and the serological study of paired sera made it possible to establish the viral and bacterial nature of the disease in 12% of cases. The expediency of the quantitative investigations of sputum, carried out twice, in combination with the study of the biological properties of opportunistic microorganisms was shown. Streptococcus pneumoniae proved to play the most important etiological role in the appearance of acute pneumonia in miners. This infective agent was detected in 82% of patients by the inoculation of sputum samples in "diagnostic" dilutions (10(-5) and higher). The associations of pneumococci with staphylococci, hemolytic bacteria and Neisseria were found to be capable of playing a significant role in the development of acute inflammation in pulmonary tissue, especially in those cases when these associations were isolated from highly diluted sputum (10(-5)).
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The results of the immunoleukolysis test in 699 women on the 32nd week of pregnancy are presented. Of these, 48 women were examined 1 month and 6 months after the third injection. In this test staphylococcal allergen and E. coli allergen were used. Staphylococcal toxoid was found to have desensitizing action in persons with enhanced initial allergic state. The authors conclude that the immunoleukolysis test may ensure differential approach to the immunization of pregnant women with staphylococcal toxoid.
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