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Biomedical subjects

G P Parfenov

Publications and source records attributed to G P Parfenov.

15 recordsLinked to original sources

[Weightlessness and elementary biological processes].

This book gives comprehensive review of the role of gravity in fundamental biological processes. The book surveys the results of experiments on precellular and unicellular organisms, plant and animal cultured cells and tissues, fungi and actinomycetes, higher plants, and insects. The book discusses essentially every experiment performed in real flights, including those in which the combined effect of microgravity and ionizing radiation was investigated, as well as many clinostat and centrifuge studies. In orbital flights unicellular organisms exhibited no gravity-dependent processes. The maximum size and basic morphology of unicellular organisms developed obeying the second law of thermodynamics do not therefore depend on space or time. Fungi retained all their properties except for gravitational ordering. Higher plants developed normally through seed-to-seed cycles: from the stage of seed germination to that of maturation of next generation seeds. Plants changed all their gravity-dependent movements. Since plant movements are irreversible, this affected their final shape, although the basic structure and size remained unaltered. The frequency of spontaneous and radiation--induced mutations changed insignificantly. The rotation of generations of plants and animals taken under study developed in a normal way. The morphological, physiological and genetic status of present-day organisms has developed under the effect of the gravity force that plays three different parts: as the creator and transformer of the abiotic environment, as the factor of natural selection, and as the factor of environmental physiology eliciting stable mechanical stresses. The effects of these gravity roles are implemented by different mechanisms and actualized in different time scales. The uneventful development of the basic biological processes in microgravity is an important factor that makes possible long-term space missions. From this point of view, the road to outer space is open to man in terms of his biology.

Animals

[Chromosome aberrations in Crepis capillaris after gamma-irradiation and clinostatism].

The rate of cell division and emergence of spontaneous and radiation chromosomal aberrations in Crepis capillaris exposed to clinostating were determined. The plants were gamma-irradiated with 300 R during clinostating when the primary roots were 1-2 mm long. The velocity of clinostat rotation was 2 rpm. The mitotic index was not affected either by clinostating alone or combined with irradiation. The exposure to clinostating did not change significantly the total frequency of nuclear aberrations or the distribution of the aberrations of the chromosomal and chromatin type as well as aberrations resulting from one or two radiation events. Thus, the effect of clinostating combined with gamma-irradiation can be considered zero.

Cell Count

[Biological research in space].

The paper presents the results of investigations carried out during the last two decades on various biological objects--microorganisms, plant seeds, insects, higher and lower plants, fish and amphibians--in real and simulation space flights. The paper discusses the current knowledge of the biological role of gravity and possible mechanisms of adaptation to weightlessness as well as the suitability of different biological objects for further space studies. Most experiments conducted in real space flights have lent support to the theoretical studies of the level and limits of weightlessness effects upon biological systems. Analysis of the data obtained in space and ground-bound experiments suggests that molecular processes are indifferent to an altered gravity and that energy metabolism plays an important role in adaptation of biological systems to zero-g.

Adaptation, Physiological

[Space biology in the 3d decade].

The paper reviews the major results of experiments on microorganisms, plants and animals flown onboard space vehicles during the past two decades. To explain the experimental findings, it is hypothesized that living beings develop an indirect adaptation to gravity effects which has a bearing only on the phylogenetic process.

Adaptation, Biological

[Reproduction and mutability of the flour beetle in weightlessness (experiments on the Saliut-6 orbital station)].

Experiments with the flour beetle Tribolium castaneus showed that in weightlessness these insects completed their cycle of development--from fertilization to the emergence of mature imago of the next generation--in the normal way. Survival of specimens, densities of cultures, duration of development and frequency of morphoses in flight and control studies were similar. Exposure to weightlessness did not increase the number of genetic changes.

Animals

Current status of the problem of the mechanism of gravity reception in plants.

Basic work carried out recently on the role of the structural-functional condition of cell organelles in the development of geotropic reaction in higher plants is reviewed. On the basis of analysis of theoretical proposals and experimental investigations of the molecular mechanism of perception and realization of the gravity stimulus, a hypothesis was developed that the key factor in the development of geotropic reaction is an interaction of cell organelles with membranes of the endoplasmic reticulum as a result of their sensing the gravity stimulus.

Aerobiosis