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Biomedical subjects

G Pacchetti

Publications and source records attributed to G Pacchetti.

6 recordsLinked to original sources
PubMed1983

A comparative cytogenetic study on cases of induced abortions in TCDD-exposed and nonexposed women.

In order to evaluate the cytogenetic findings previously obtained on induced abortions in women exposed to 2,3,7,8 tetrachlorodibenzo-p-Dioxim (TCDD) after the Seveso accident, chromosome analyses were carried out on a comparable control sample. The frequencies of aberrant cells, the relative proportions of individual types of chromosome aberration, the average number of lesions per damaged cell, and the frequencies of polyploids do not differ significantly in maternal blood and placenta in the two samples. A highly significant increase in the frequencies of aberrant cells and in the average number of aberrations per damaged cell was found in the fetal tissues in the group of exposed pregnancies. A noticeable feature of the data on the frequencies of cells with aberrations is the marked variability among individuals within tissues and within samples. On the basis of these results, the authors point to the need to continue cytogenetic investigations on interrupted pregnancies in TCDD-exposed and nonexposed women.

Abortion, Induced↗
PubMed1982

The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis.

Satellite associations were used as parameters to test nucleolar organizer activity. Assuming that toxic and/or mutagenic agents may affect the ribosomal genes, satellite associations in human lymphocytes were analysed following exposure to X-rays and compared with the satellite association pattern of subjects exposed to TCDD. A significant decrease in the satellite association frequency in D group chromosomes was found both in irradiated lymphocytes and in subjects exposed to Dioxin. The findings seem to be in accordance with the hypothesis based on random damage of functional nucleolar organizing regions.

Cells, Cultured↗
PubMed1981

Chlorinated hydrocarbons in fish from the river Po (Italy).

Pesticides and PCBs levels have been determined in two species of fish from the river Po during 1979--1980 at five sampling stations in different seasons. Significant higher levels have been observed in most industrial areas. When expressed on the basis of fat content, river fish levels are higher than those reported for fish from the Adriatic sea. Using experimental BCF (bioconcentration factors), pesticides and PCB concentrations in water have been calculated from fish values, and compared with measured concentrations.

Animals↗
PubMed1981

Computer-assisted analysis of chromosomes of the European crested newt.

A computer programme has been developed for partly automating the process of chromosome analysis of the European crested newt (Triturus cristatus carnifex). Chromosome classifications made by the computer and by the cytologist have been compared for a sample of 130 spermatogonial metaphase. The twelve pairs of chromosomes have been classified into three groups. The overall error rate achieved by the computer was 14% for chromosome assignment to single pairs, and 3.8% for chromosome assignment to the proper group.

Animals↗