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Biomedical subjects

G Palazzini

Publications and source records attributed to G Palazzini.

32 records · Page 2Linked to original sources
PubMed1984

Comparison of the properties of human hemoglobin covalently bound to carboxyl dextrans with free and polymerized hemoglobin.

Human stroma-free hemoglobin (SFH) was coupled in the oxy or deoxy conformations to carboxyldextrans through amide bonds. The complexes were analysed by gel permeation high performance chromatography, and their molecular mass distribution ranged from 90,000 to 300,000. Covalent coupling of SFH to carboxyldextrans determined an increase of the oxygen affinity when compared to free SFH. The P50 of the complex formed from carboxyldextrans and SFH in the oxy state was lower than that of the derivative obtained from SFH in the reduced state. On the other hand, glutaraldehyde cross-linked SFH still showed cooperativity when reacted in the deoxy state and in the presence of pyridoxal phosphate, and its oxygen affinity was similar to that of the free pyridoxylated SFH. These results lead to exclude the potential use of these dextran-SFH complexes as oxygen carriers.

Chemical Phenomena↗
PubMed1983

Erythrocyte antioxidant enzymes and selenium serum levels in an Andean population.

A preliminary study indicated that erythrocyte antioxidant enzyme activities were enhanced in chronic hypoxaemic patients, in whom an increased oxidant stress could be present as a consequence of augmented haemoglobin autoxidation. We have now evaluated the behaviour of erythrocyte antioxidant enzymes and of their related trace metal serum levels in conditions of chronic hypobaric hypoxia in an Andean population living at high altitude (3800 m above sea level), and in a similar ethnic group living at sea level. The results indicate a significant reduction in erythrocyte glutathione peroxidase activity and a low serum level of selenium in the Andean population. Thus, in contrast to what happens in chronic hypoxaemic patients, this group of Andean subjects seems to be poorly protected against oxidant stress, probably as a consequence of selenium deficiency in the diet.

Adult↗
PubMed1980

Serum myoglobin, total CK and MB CK isoenzyme after D.C. cardioversion and during the early phase of acute myocardial infarction.

Myoglobin, total CK and MB CK isoenzyme were determined in the sera of 6 patients admitted with arrhythmias and treated with D.C. countershock and also in 37 patients with acute myocardial infarction or anginal syndrome. All the three tests were increased in patients with myocardial infarction. Serum myoglobin seems sufficiently sensitive and specific but the time required for the assay is a limiting factor for practical use in emergencies. After electrical cardioversion, myoglobin and CPK remain normal, although MB isoenzyme was increased in two of six patients. These results suggest that electrical cardioversion in itself does not influence serum levels of myoglobin. The occasional increase of MB CK observed after cardioversion seems to be the consequence of an easier release of the enzyme due to a myocardial injury.

Adult↗
PubMedDate not supplied

[Mininvasive treatment of strangulated paraesophageal hiatal hernia in emergency. Case report].

The Authors report a case of strangulated paraesophageal hiatal hernia occurred in a elderly woman and treated with laparoscopic approach. After review of the literature regard on this uncommon pathology that present about 5% of the hiatal hernias, they emphasize that the laparoscopic approach is appropriated even in emergency and comprises complete reduction of the stomach in abdomen, control of suitable position of the distal esophagus and cardias and making of effective hiatus-plasty.

Aged↗
PubMedDate not supplied

[Complicated diverticular disease. Three cases of colovesical fistulas and review of literature].

Colovesical fistulas represent a possible less frequent complication of diverticular disease of colon. They represent a complex condition because of the possible and unexpected evolution into a septic shock with a high risk of death. The Authors report three cases of colovesical fistula as a complication of diverticular disease. They underline the importance of early diagnosis, specific antibiotic therapy and appropriate surgical therapy realized in one or two stages according to general and local conditions of each patient.

Aged↗
PubMedDate not supplied

Techniques of rectal oncologic survey.

The possibility of constructing very low anastomoses using stapling devices led many surgeons to reduce the length of the distal clearance to 1-2 cm. This made it possible to perform a low anterior resection instead of an abdominoperineal resection of the rectum in a greater number of cases. Furthermore, the enthusiasm in preserving sphincteric function induced some Authors to perform a local excision for tumors of the distal portion of the rectum. On the other hand, in order to improve patients' survival after curative operations for cancer, either of the rectum or rectosigmoid junction, other surgeons have adopted a more aggressive approach, extending exeresis to the peri-aortocaval and pelvic nodes, and to the possible liver metastases as well. On the basis of our experience (374 cases from 1972 to March 1989) and a critical review of the literature, indications, techniques, and results of curative operations for both rectal and recto-sigmoid junction cancer are examined. The role of extended abdomino-pelvic lymphadenectomy is also discussed. The Authors believe that in the absence of a reliable evaluation of the potential of these tumors, an aggressive approach is required. Local excision is reserved to very selected cases, which should undergo an intensive follow-up in order to detect recurrences at a very early stage.

Anastomosis, Surgical↗
PubMedDate not supplied

Stapled sutures in digestive tract surgery.

A six-year experience with mechanical sutures in digestive tract surgery is reported. Forty-nine esophageal resections during azygo-portal disconnection were performed since 1979 up to June 1986. Four patients died in the early postoperative course with no evidence of suture-related complication. One patient developed an anastomotic stricture (2.2%), which was successfully dilated. Fifty-three total gastrectomies with stapled reconstruction were performed between 1980 and June 1986. Two patients died soon after surgery for reasons unrelated to the suturing technique. Two strictures of the esophagojejunal anastomosis (3.9%) occurred two to three months after surgery and underwent successful dilation. One esophagojejunostomy (1.9%) leaked and one (1.9%) underwent uneventful remedial surgery (conversion of an omega-shaped loop to a Roux-en-Y procedure). Ten isoperistaltic jejunal interpositions, six Billroth I partial gastrectomies and 14 Roux-en-Y loops for hepatico- or pseudo-cystojejunostomy were performed since 1983 up to June 1986 in the absence of any operative morbidity or mortality. Twenty-three right colectomies were performed from 1983 to June 1986. The only complication reported was one leakage (4.3%) which spontaneously healed. Ninety-eight patients underwent formal colonic resections (anterior resection of the rectum, left hemicolectomy, subtotal and total colectomy) from 1981 to June 1986. Two patients (2%) died for reasons unrelated to the suturing technique. Three colorectal anastomoses (3%) developed a leak, one of which required surgical revision. One stricture (1%) was recorded in a recurrence-free patient three months after surgery. One patient (1%) complained of minor rectal bleeding. Two patients (2%) developed small anal fissures due to forced passage of the instrument.(ABSTRACT TRUNCATED AT 250 WORDS)

Anastomosis, Surgical↗
PubMedDate not supplied

[Surgical repair of laparocele with expanded PTFE: technicalities].

Surgical repair of ventral hernias may often be quite difficult; however, the use of prosthesis, now generally accepted by many surgeons, has improved the results of such type of surgery. The Authors experience confirm the safety of the expanded PTFE and its versatility of employment, obtaining good functional and aesthetic results.

Adult↗