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Biomedical subjects

G Palimeris

Publications and source records attributed to G Palimeris.

At least 19 recordsLinked to original sources
PubMed1999

Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece.

PURPOSE: Behçet's disease (BD) is known to be associated with HLA-B51 in many different ethnic groups. Recently MICA, a member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), was identified near the HLA-B gene, and a triplet repeat microsatellite polymorphism was found in the transmembrane (TM) region. Because a strong association with BD of one particular MICA-TM allele, A6, was shown in a Japanese population, the present study was conducted to investigate microsatellite polymorphism in Greek patients with BD to know whether this association is generally observed in BD occurring in other populations. METHODS: Thirty-eight Greek patients with BD and 40 ethnically matched control subjects were examined for MICA microsatellite polymorphism using polymerase chain reaction (PCR) and subsequent automated fragment detection by fluorescent-based technology. RESULTS: Similar to the Japanese patients with BD, the phenotype frequency of the MICA-TM A6 allele was significantly increased in the Greek patients with BD (50.0% in control subjects versus 86.8% in BD cases), with an odds ratio (OR) of 6.60 (P = 0.0012). The MICA-A6 allele was found in a high frequency both in males and females (weighted OR = 6.68; P = 0.0017). No association was found between the A6 allele and several disease features. A strong association exists between the MICA-TM A6 allele and the B*5101 allele in both the control subjects and patients with BD (weighted OR = 44.39; P = 0.0000023). CONCLUSIONS: This study revealed in Greek patients a strong association of BD with a particular MICA-TM allele, MICA-A6, providing insight into the molecular mechanism underlying the development of BD.

Adult↗
PubMed1998

HLA-B*5101 in Greek patients with Behçet's disease.

Behçet's disease (BD) is a recurrent systemic vasculitis of unknown etiology. Genetic factors and infectious agents seem to be related to the etiology and pathogenesis of the disease. BD is strongly associated with HLA-B51 antigen in many ethnic groups. As there are differences in HLA profile in different ethnic groups, we designed this case-control study to examine the association of HLA-B51 alleles and BD as well as to investigate the influence of sex, age at development of the International Study Group (ISG) for Behçet's Disease criteria and certain features of disease severity on the strength of this association. The study includes 62 Greek BD patients who fulfill the ISG criteria for Behçet's disease and 87 controls. Serological HLA Class-I typing was performed by standard microlymphocytotoxicity technique. HLA-DNA typing for the B5 group was performed in all B51 subjects and controls by PCR-SSO. Allele B*5101 was found in 80% of BD patients and in 26% of controls (odds ratio (OR) 10.48, p < 10[-6]). Males who carry this allele have a higher risk than females for BD (OR 16.97 and 5.74 respectively). B*5101 predisposes to BD at a younger age in both sexes and to the development of erythema nodosum (OR = 11, p = 0.004). This was confirmed by multiple logistic regression analysis. A weak but not significant association was found between B*5101 and uveitis (OR = 2). No association was found between B*5101 and vasculitis or skin lesions in either sex. It was concluded that in the Greek population allele B*5101 is a predisposing marker for BD, as in most ethnic groups, and that this allele predisposes to the development of the disease at a younger age in both sexes and to the development of erythema nodosum.

Adolescent↗
PubMed1989

[The macula in Adamantiades-Behçet disease].

Adamantiades-Behçet disease is a well known clinical entity in the Mediterranean area. Signs and complications in these patients, arising from the macular area, are often overlooked for a prolonged period of time, because they are masked by the inflammatory signs of the anterior segment and/or the vitreous. Although blindness, in most cases, is the result of the optic disc atrophy, the macular alterations--as a sequelae of inflammation--are responsible for the low visual acuity. The authors in a retrospective clinical study of the last 100 consecutive cases of A-B disease, studied these macular alterations in detail. Their findings are also described in detail. Therapeutic modalities center around treatment with steroids, Cyclosporine A, and argon laser application. The results obtained from a long follow-up period are discussed.

Behcet Syndrome↗
PubMed1983

Glycose tolerance curve, HbA1 determination and cataract.

In a series of patients with advanced cataract and in another one of patients with incipient cataract, aged under 55 years, with no history of trauma or diabetes and a normal fasting blood sugar, the standard glycose tolerance test, as well as the HbA1 determination were performed. About 34% of the patients of the first group and 10% of the second group showed abnormalities of the tests. Asymptomatic diabetes was diagnosed in these patients and it is concluded that glycose intolerance is common in patients with advanced or incipient cataract, under 55 years of age, who show no glycosuria and have a normal fasting blood sugar on routine examination.

Adult↗
PubMed1979

Some observations on the treatment of ischemic optic neuropathy.

We examined the efficacy of the treatment with steroids, vasodilators, and vitamins B1, B6, and B12 in 23 cases of anterior ischemic optic neuropathy treated at the Athens University Eye Clinic. We stress the necessity of an extended medication for 2 to 3 months, depending upon the improvement of visual acuity. Good results were achieved in 14 of the 23 patients.

Aged↗
PubMed1978

On the management of congenital cataract with Dardenne's equipment.

After a short review of the operative techniques applied for the extraction of congenital cataract the authors describe the method of irrigation-aspiration of the lens material by means of the Dardenne equipment. Following an analysis of the results obtained with this procedure in a number of patients operated on at the Eye Clinic at Athens University, they discuss the advantages and shortcomings of the method, insisting in particular on: the importance of a complete removal of the lens debris; the careful scraping of the posterior lens capsule, and the necessity of an intensive postoperative anti-inflammatory therapy, especially in cases of congenital cataract due to rubella.

Cataract↗
PubMed1977

Family distribution of concomitant squint in Greece.

From a study of a large number of brothers and sisters suffering from concomitant squint, the following data were obtained: (1) 42-9% of the patients showed congenital strabismus. (2) In 96-5% of the sibs strabismus was of the same type. (3) The presence of a significant refractive error occurred in 82-8% of the patients. (4) In all twins strabismus appeared at the same age in both twins, and the squint and the refractive error were of the same type. (5) The distance of the patients' homes from Athens had no effect on either (a) the time intervening between the onset of squint and the first visit to the eye specialist, or (b) the effectiveness of treatment.

Age Factors↗
PubMed1977

Some observations concerning expulsive hemorrhage.

The authors describe the occurrence of expulsive hemorrhage in 12 patients out of a total of 23,985 intraocular surgical operations (0.05%). As principal etiological factors they regard increased intraocular pressure in combination with coexisting hypertension and vascular sclerosis. Attention is drawn to the manifestation of the complication during the last years under the mild form of subchoroidal hemorrhage as a result of the use of osmotically acting drugs. In 9 cases the eyeball was salvaged.

Aged↗
PubMed1977

[Electroretinographic changes in experimental metalloses].

In this experimental study the authors studied the Eclectroretinographic alterations and the histological lesions after the introduction of foreign bodies of iron and copper into the vitreous body of eyes of rabbits. The ERG alterations depend on the kind of the intraocular foreign body and on the size and the time it remained into the eye. These alterations are characterised either by a parallel diminution of the a and b wave of the ERG, or by an increase of the a wave while the b wave becomes flat. From the histological studies it was found that the iron is deposited into the nucleus and the cytoplasm in the form of granules, while the copper causes a violent inflammatory reaction and is deposited extracellularly.

Animals↗
PubMed1976

Experimental uveitis induced by prostatic antigens.

Experimental uveitis was induced in male rats following their repeated systemic and intravitreous immunization with prostatic antigen and CFA. The ensuing uveitis was proved histologically. Heteroimmunized rabbits and female animals showed less response and the level of antibodies detected was lower. Anti-prostatic antibodies were determined by the TRC flocculation and PCA techniques. Ouchterlony's method gave positive results not only for prostatic but also for other ocular antigens when tested against the same test sera.

Animals↗
PubMed1976

The third component of complement (C'3) level in patients with uveitis.

In 23 cases of endogenous uveitis the third component of the complement (C'3) system was determined by the immunodiffusion method. No statistical difference was found in uveitis patients as a whole in comparison with the normal controls; although a rather high value of C'3 was found in six cases of Eales' disease and in three cases of Behçet's disease. The significance of these results is discussed.

Adolescent↗