Efficacy of phenelzine in geriatric depression.
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Biomedical subjects
Publications and source records attributed to G Pandey.
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To assess the relationship of baseline cortisol to the 1 mg dexamethasone suppression test (DST), 4 p.m. baseline and 4 p.m. postdexamethasone blood samples were drawn on 52 consecutive depressed outpatients. Baseline cortisol correlated significantly with post-DST values, and baseline levels above 15 micrograms/dl predicted DST nonsuppression with 90.4% accuracy. These data lend some support to the usefulness of baseline cortisol determination in depressed outpatients in whom a full DST may be difficult.
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We divided bipolar patient samples into two groups: Group I (off lithium 10 days to 2 weeks, n = 14) and group II (off lithium 3 weeks or longer, n = 13). Only group I was significantly different from controls. The mean for group II was significantly different from that for group I but not that for controls. Previous reports may have exaggerated the number of "high ratio" patients due to a treatment artifact. We recommend that patients be tested only after having been withdrawn from lithium treatment for 3 weeks or more. Otherwise spurious differences between patients and controls may result.
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A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased response to dopaminergic stimulation was demonstrated in the total chronic schizophrenic group.
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