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Biomedical subjects

G Parizel

Publications and source records attributed to G Parizel.

At least 19 recordsLinked to original sources

Stenosis in a coronary collateral artery--a case report.

The coronary cineangiography of a man with an inferoposterior myocardial infarction is reported. An occlusion of the proximal right coronary artery and an occlusion at the origin passing around the left atrial wall of the circumflex artery was observed. A large collateral artery connected the right coronary artery and the distal circumflex artery. This vessel showed a significant stenosis of 70%. This case suggests that collateral arteries are not protected from atherosclerotic degeneration. Alternatively, since the exact caliber of the anastomosis before the occlusion of the recipient artery is not known, an extrinsic compression or kinking may have generated the stenosis at the time of the flow-related dilatation of the vessel.

Aged

Pulmonary fat embolism presenting as chronic respiratory failure.

A patient is presented with progressive respiratory failure, caused by pulmonary fat embolism as proved by an open lung biopsy. Four and a half yrs earlier, she underwent a right hip operation. We surmise that a loosening hip prosthesis caused the marrow embolisation.

Aged

Diagnosis of aortic dissection. Comparison of investigatory methods--case report.

A case is presented of a patient with an acute aortic dissection, rapidly followed by thrombosis of the false channel. The classical aortoangiography failed to give adequate information, whereas newer, less invasive investigation methods gave images that finally led to the correct diagnosis. The value of these methods in the diagnosis of aortic dissection is discussed.

Aortic Dissection

Peritoneal dialysis in acute renal failure due to cholesterol embolization: two cases of recovery of renal function and extended survival.

Recovery of renal function and extended survival after acute renal failure due to cholesterol embolization are possible, as demonstrated by the case history of two patients. Both were treated with peritoneal dialysis during their acute insult and had a serum creatinine of 1.7 mg/100 ml and 2.4 mg/100 ml, respectively, 12 and 60 months after diagnosis. Peritoneal dialysis is the preferred procedure for the replacement of renal function in these patients since it achieves good control of blood pressure and volume overload and avoids the need for vascular access and heparin administration.

Acute Kidney Injury

Necrotizing fasciitis precipitating diabetic ketoacidotic coma.

Necrotizing fasciitis is a rapidly spreading infection of the subcutaneous tissue and fascia; diabetes mellitus appears to be the most frequent underlying disease. Early diagnosis and immediate aggressive surgical therapy are paramount to curtail morbidity and mortality, but diagnosis is often difficult and unnecessarily delayed. We describe a case of necrotizing fasciitis precipitating diabetic ketoacidotic coma where correct diagnosis was not made until the 14th hospital day. We stress the fact that physicians caring for critically ill patients should be keenly aware of the possibility of necrotizing fasciitis when tending diabetic patients with unexplained fever; failure to recognize the disease can have devastating results. Finally, we believe this to be the first reported case of diabetic ketoacidotic coma precipitated by necrotizing fasciitis.

Adult

Diffuse intravascular coagulation complicating thrombosis of a popliteal aneurysm: a case report.

Several reports have described the association between diffuse intravascular coagulation (DIC) and arterial aneurysmal disease. We report a patient with extensive arterial aneurysmal disease who developed transient severe DIC during thrombosis of a popliteal aneurysm; following surgical removal of the thrombosed aneurysm, he was found to have chronic subclinical DIC. We believe thrombosis should be added to the complications of aneurysms which can cause DIC, next to dissection and rupture. The chronic DIC occurring after removal of the thrombosed aneurysm was characterized by an abnormal prothrombin time (PTT), low fibrinogen levels and elevated fibrin split products (FDP's); this pattern may be characteristic of the DIC complicating arterial aneurysms.

Aged

Prolonged runs of ventricular tachycardia as a complication of theophylline intoxication. Report of a case.

A 70-year-old patient who developed ventricular tachycardia (up to several hundreds of consecutive ventricular complexes) in the presence of theophylline intoxication (29 micrograms/ml) is reported. Ventricular tachycardia is a rare complication of theophylline intoxication and, to our knowledge, has not yet been reported with theophylline levels below 40 micrograms/ml. The occurrence of hypokalemia and its possible arrhythmogenic effect in theophylline intoxication is discussed. The role of low theophylline clearance in developing iatrogenic theophylline intoxication is emphasized. Patients with theophylline intoxication should be carefully monitored, even when the serum level does not seem to be dramatically high.

Aged

6-keto-PGF1 alpha levels and prostacyclin therapy in 2 adult patients with hemolytic-uremic syndrome.

Evidence supports the hypothesis that plasma prostacyclin activity is deficient in hemolytic-uremic syndrome (HUS). We studied 2 adult patients with HUS. Plasma levels of 6-keto-PGF1 alpha, the stable metabolite of prostacyclin, were measured by radioimmunoassay. Both patients were found to have elevated 6-keto-PGF1 alpha levels. These findings are in contradiction with the prostacyclin deficiency hypothesis and with earlier reports of low or undetectable plasma levels of this metabolite. The patients were treated with IV prostacyclin after a single plasma exchange. The first patient, admitted with advanced renal failure, obtained a rapid remission but renal function did not recover; the second patient, admitted with a less pronounced degree of renal failure, reacted slowly to therapy but renal function partially recovered. We believe that, if any benefit is to be expected from prostacyclin therapy in HUS, it should be started early in the course of the disease.

6-Ketoprostaglandin F1 alpha

Determination of free thyroid hormones and their binding proteins in a patient with severe hyperthyroidism (thyroid storm?) and thyroid encephalopathy.

A patient with severe hyperthyroidism (thyroid storm?) and thyroid encephalopathy is described. During her illness only a slightly raised level of total thyroxine and a normal level of total triiodothyronine was found in contrast with very high levels of free thyroid hormones. Very low levels of thyroxine binding globulin, albumin and low levels of thyroxine binding prealbumin in contrast with nearly normal values of T3 resin uptake were observed. All parameters of thyroid function returned to normal after therapy.

Adult

Pacemaker endocarditis: contribution of two-dimensional echocardiography.

A case of pacemaker endocarditis is presented. Electrode vegetations could be diagnosed by two-dimensional echocardiography. Prolonged antibiotic therapy failed. Only when the entire pacing system had been removed by cardiotomy with cardiopulmonary bypass, the infection cleared.

Echocardiography

Hypothalamic-pituitary function in myotonic dystrophy.

Function of the hypothalamic-pituitary axis was investigated in seven patients with myotonic dystrophy (MD). HGH and ACTH secretion were normal. TSH response to TRH was impaired in about half the cases, without concomitant thyroid dysfunction. LH and FSH levels were often elevated, with inconsistent response to LH-RH stimulation, Gonadotrophin disturbances in MD have previously been attributed to a primary gonadal lesion, characteristically seen in this disease. High prolactin levels in six of our seven patients however suggest that gonadal failure may be also be due to hyperprolactinemia through the direct anti-gonadal effect of prolactin and its interference with hypothalamic-pituitary regulation of gonadotrophin secretion.

Adrenocorticotropic Hormone

Hydrogen cyanide poisoning: treatment with cobalt EDTA.

Three case reports are presented of employees who suffered varying degrees of exposure to hydrogen cyanide and their subsequent clinical courses following treatment with cobalt EDTA. A review of treatment modalities for CN- toxicity is given. It is concluded that, because of the degree of patient symptomatology associated from the use of cobalt EDTA, this therapy be reserved only for patients with the most severe degress of exposure to CN(-), and that in all other cases combined sodium nitrite and sodium thiosulphate therapy should be employed.

Accidents, Occupational