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Biomedical subjects

G Paulson

Publications and source records attributed to G Paulson.

At least 19 recordsLinked to original sources
PubMed1994

Creutzfeldt-Jakob disease: a review.

Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and ultimately fatal disorder of the central nervous system. CJD occurs worldwide with an incidence of approximately .5-1 new cases per million population per year. Despite numerous epidemiological and laboratory studies, the etiologic agent and mode of transmission remain unclear. Clinical diagnosis is challenging and is based on clinical symptoms. No specific treatment is available and medical management remains limited to supportive care. Health care workers must be well informed about necessary precautions and decontamination procedures. Nurses play a major role in providing supportive care, educating community organizations and agencies about CJD and assisting the family through the grieving process.

Adult↗
PubMed1986

[Update on prolactin].

Normal serum prolactin levels range from 5 to 20 ng/ml (circadian rhythm, effect of stress, relation with estrogen secretion). Neuroleptics increase serum prolactin levels. Normal concentrations are restored within 24 to 48 hours of discontinuation of the drug. When neuroleptics are given for a long period of time, serum prolactin concentrations fall gradually to low levels. There is no conclusive evidence that prolactin plays a role in breast tumors in women. Epidemiologic studies have shown that neuroleptics are not responsible for increased incidences of these tumors.

Animals↗
PubMed1986

Stimulatory effects of methyltestosterone on pituitary gonadotropic cells and testes leydig cells of the three-spined stickleback, Gasterosteus aculeatus L., in winter.

Male three-spined sticklebacks were kept for a month in short photoperiod at ca. 20 degrees in winter. During this period methyltestosterone (MT), dissolved in the water (35 micrograms/liter), stimulated the appearance of breeding colors and kidney hypertrophy, characters which were both absent in the controls. MT furthermore prevented the onset of spermatogenesis. The gonadotropic cells of the MT-treated fish contained significantly more dilated endoplasmic reticulum and less granules than those of the controls. The nuclei of the testes Leydig cells were enlarged after treatment with MT. These findings suggest the existence of a positive feedback of androgen on the gonadal-pituitary axis of the male stickleback in winter.

Animals↗
PubMed1982

Effects of vestibular stimulation in seizure-prone children. An EEG study.

Concern that vestibular stimulation may induce seizures in seizure-prone children has been based on hearsay and unconfirmed clinical impressions of practicing therapists. To clarify this issue, we took electroencephalographic recordings of seizure-prone children before, during, and after specific vestibular stimulation. Ten children with seizure histories, 5, to 15 years of age, were exposed to warm and cold caloric vestibular stimuli. Electroencephalographic activity was recorded before, during, and after each vestibular stimulus; recordings were rated and compared prevestibular and postvestibular stimulation. Electronystagmographic recordings were also taken. Results show that vestibular stimulation does not accentuate the abnormal brain wave pattern in seizure-prone children. Six of 10 subjects had a significant reduction in paroxysmal activity (p less than .02). Possible explanations for clinical reports of vestibular induced seizures are given, with suggestions for precautions when applying vestibular stimulation to seizure-prone children.

Adolescent↗
PubMed1979

St Louis encephalitis in Ohio, September 1975: clinical and EEG studies in 16 cases.

In 1975, during the largest epidemic of St Louis encephalitis (SLE) in the United States, 416 cases were diagnosed in Ohio. Persons who were admitted to two Columbus (Ohio) hospitals with suspected acute viral CNS infection were prospectively studied to define the virologic and clinical aspects of SLE. Sixteen cases of SLE were diagnosed serologically. Fifteen patients had signs of encephalitis and one had aseptic meningitis. Six patients had the syndrome of inappropriate antidiuretic hormone secretion. Other frequent findings included moderate peripheral leukocytosis and CSF pleocytosis, with mild elevation of CSF protein levels but normal glucose levels. Severe neurologic sequelae were infrequent. The EEG proved valuable in diagnosis and prognosis. Results of brain scans were normal. Virus in CSF or urine was not demonstrated, nor was viral antigen in CSF or urine sediments. Specific antibody was found in the sera and CSF of all patients who were tested, but interferon was not detected.

Adult↗
PubMed1978

Mass and infrared spectra of diaryl and aryl alkyl sulfate diesters.

The synthesis and the infrared and mass spectra of diaryl and aryl alkyl sulfate diesters are described. The mass spectra of these two classes of compounds consistently showed an intense molecular ion and two or three additional intense, diagnostic ions. Their infrared spectra also gave information useful for characterizing and differentiating these two classes of compounds.

Benzene Derivatives↗
PubMed1978

The conversion of aryl sulfate ester salts to alkyl aryl derivatives suitable for analysis by electron impact mass spectrometry.

A series of monosubstituted (CH3, CH3O, Cl Br or NO2 at the O, m and p position) phenyl sulfate ester salts were derivatized to form n-propyl aryl sulfate diesters. The derivatization was accomplished by reacting aryl sulfate ester salts, AgClO4 and n-propyl iodide in SO2 at--40 degree C. The mass spectra of all the n-propyl aryl sulfate esters showed an intense molecular ion and intense diagnostic peaks at M--42 ([aryl--OSO3H]+) and M--122 ([ARYL--OH]+). The utility of this procedure for derivatizing selected sulfate ester conjugated xenobiotics and steroids was demonstrated.

Arylsulfonates↗