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Biomedical subjects

G Pavlović

Publications and source records attributed to G Pavlović.

13 recordsLinked to original sources

Diiodo(3,4,5,6-tetrahydropyrimidinium-2-thiolato-S)mercury(II).

The reaction of 3,4,5,6-tetrahydropyrimidine-2-thione (H(4)pymtH) with mercury(II) iodide in methanol in a 1:1 molar ratio resulted in the formation of single crystals of the title compound, [Hg(C(4)H(8)N(2)S)I(2)]. The Hg atom is coordinated by one S atom from H(4)pymtH at 2.456 (2) A and by two I atoms at distances of 2.6872 (7) and 2.7044 (6) A, and has a characteristic deformed trigonal coordination geometry. The molecule has crystallographic m symmetry but the Hg atom is disordered above and below the mirror plane.

Journal Article↗

[The popliteal artery entrapment syndrome].

The authors are presenting 8 patients with 9 cases of popliteal artery entrapment syndrome. There were one female, and 7 male patients with average age of 36.4 (25-54) years. Six cases were manifested with acute, 2 with chronic foot ischemia, while one case was asymptomatic. For diagnosis a combination of Doppler sonography and transfemoral angiography, was used. Eight cases were operated using posterior, while in one medial approach to the popliteal artery. The types I and IV of the popliteal artery entrapment syndrome were found in one case, type II in two cases, type III in 4 cases, while in one case a type of syndrome had not to be identified. During the operation the resection of the anomalous muscle and reconstruction of the popliteal artery, were done in 8 cases. In one case muscle resection or arterial reconstruction, were not necessary. The early potency rate and limb salvage, were 100%, while long term potency rate after mean follow up period of 6.3 years was 83.5%. The acute or chronic foot ischemia in health, young persons without typical atherosclerotical risk factors, suggests on popliteal artery entrapment syndrome.

Adult↗

[SEM/EDAX determination of zinc levels in dentin after administration of zinc oxide-eugenol paste].

The quantitative EDAX analysis of zinc contents was performed in the dentin samples of markedly different morphology after the use of ZOE paste in various time intervals. EDAX analysis has shown that samples of the ground dentin have high zinc content. The mean value of zinc content was 5.42% ten days after the use of ZOE paste and 19.16% after 30 days. Zinc content in samples of the polished dentin determined by EDAX analysis was significantly lower compared to that of the ground dentin. The presence of paste was not found on samples of the polished dentin ten days after the use of ZOE paste while after a 30-day treatment zinc content was only 1.29%.

Dentifrices↗

[Determination of calcium content in dentine after application of ZOE paste].

The calcium in dentine after the application of zinc oxide/eugenol paste (ZOE) was determined. The results were compared with the values valid for normal dentine calcium content in order to check some hypothesis suggesting that the effects of ZOE paste on dentine could reduce the calcium content and cause demineralization of dentine. The results obtained for calcium content in various layers of dentine have shown that only the layer of dentine-enamel junction (which should be removed before the application of ZOE paste) contained the increased concentration of calcium in comparison to anatomically deeper layers. The average calcium content in deeper dentine layers are very similar, especially in dentine layers directly exposed to action of ZOE paste, as well as in the layer on which ZOE paste was not applied.

Calcium↗

[Determination of content and type of zinc binding in dentine after application of ZOE paste].

The article deals with the determination of zinc content in dentine after ZOE paste application as well as the investigation of the morphology ant morphological dentine changes caused by the paste action. The obtained data for the content of zinc in various dentine layers have shown that a marked zinc content elevation comparing to the natural content occurred only in the layers of which ZOE paste was directly applied. In anatomically deeper dentine layers (under ZOE paste), the content of zinc corresponded to the natural dentine level. On the basis of data obtained, it was concluded that during ZOE paste application no concomitant zinc diffusion occurred through the tooth tissue, but only zinc content was elevated in the dentine contact layer. However, on the basis of these data it was not possible to conclude weather chemical changes in the contact paste-dentine layer occurred or it made only a strong mechanical effect of paste on dentine adhesion. The investigation of dentine morphology which was removed by grinding (by mean used in dentistry practice) showed that this way of preparing the specimens caused the natural dentine structural alterations. By grinding dentine topography was completely affected. Very deep lesions and visible augmentation of the contact dentine surface that facilitated ZOE paste adhesion, occurred. Thus the permanent ZOE paste attachment to dentine occurred and dentine free energy decreased. In this way permanent adhesion of cement for dentine was impossible with negative consequences for the final therapy.

Dentin↗

[The antiphospholipid syndrome in systemic connective tissue diseases].

The aim of the study was to prove the incidence of antiphospholipid syndrome (APS) in systemic connective tissue disease (SCTD), especially in systemic lupus erythematosus (SLE) and to find out serologic markers of APS. Of 94 patients with SCTD followed up in the last three years 80 had SLE, 7 Sjogren's syndrome, 3 systemic vasculitis, 2 combined systemic connective tissue disease, 1 rheumatoid arthritis, 1 Sjogren's syndrome with vasculitis. Antiphospholipid antibodies (ApSt) were determined by ELISA method. In 31 of 80 patients with SLE (38.07%) antiphospholipid antibodies were proved. In lo of 31 (32.26%) signs of systemic lupus or the presence of APS markers have not been found, while 21 of 31 (67.74%) had some of clinical manifestations of APS (most commonly thrombocytopenia or vascular thrombosis) with evolution of the basic disease. Among our patients with SLE the most common finding was IgG antibody isotype-in 14 or 66.66% of cases. In 5 of 7 patients with Sjogren's syndrome ApAt were proved without clinical evolution of the basic disease and APS. Only 2 of 7 patients of this group showed, together with more increased ApAt, mild evolution of the basic disease and manifestation of APS (livado reticularis and recurrent venous thrombosis).

Antiphospholipid Syndrome↗

[Anticardiolipin antibodies in patients with ischemic brain disease].

Anticardiolipin antibodies are best defined antiphospholipid antibodies and a recently described marker of increased risk for ischemic brain disease. Investigations were performed in 151 patients with ischemic brain disease in order to determine the occurrence of anticardiolipin antibodies and define the clinical characteristics of patients with an increased titer of anticardiolipin antibodies. Measurement of anticardiolipin antibody titer was performed by immunoenzyme method. Besides, analyses of certain tests indicative for blood coagulative properties were also done. In addition, the occurrence of anticardiolipin antibodies was investigated in 49 patients with other non-immune neurological diseases and disorders. Control sera were obtained from 50 healthy subjects and 6 patients with senile cataract. Investigation showed the increase of anticardiolipin antibody titer in 22.8% of the patients with ischemic brain disease (30% with transient ischemic attacks, 19% with brain infarction) and in 4% of the patients with other neurological disorders of non-immunological genesis. The patients with increased titer of anticardiolipin antibodies suffered more frequently from recurrent forms of ischemic brain disease, all of them were below 50, and they had less risk factors for atherosclerosis and ischemic brain disease. It was concluded that the presence of increased titer of anticardiolipin antibodies in younger patients with recurrent forms of ischemic brain disease and less risk factors could be the marker of the increased risk for ischemic brain disease.

Adult↗

[Dacron and polytetrafluoroethylene aorto-bifemoral grafts].

INTRODUCTION: In reconstructive procedures of the abdominal aorta synthetic grafts are today mostly used. There are two types of bifurcated synthetic grafts: Dacron and polytetrafluorethilene (PTFE). In many papers these grafts are compared in aortobifemoral position. Karner 1988, and Lord 1988, found no significant difference between them after aortobifemoral reconstructions. In 1955. Paaske wrote about a new "stretch" bifurcated PTFE graft in aortobifemoral position. Comparing this material with standard Dacron graft, he only found a shorter operating time. The aim of this paper is to compare Dacron and PTFE bifurcated grafts in aortobifemoral position in patients with aortoiliac occlusive diseases. MATERIAL AND METHODS: This prospective study included 283 aortobifemoral reconstructions due to aortoiliac occlusive diseases operated between January 1st, 1984 and December 31st, 1992 at the Institute for Cardiovascular Diseases of the Serbian Clinical Centre in Belgrade. Bifurcated PTFE grafts were used in 136 patients, and nonimpregnated knitted Dacron grafts in 147 subjects. There were 25 (8.8%) female and 258 (91.2%) male patients, average age 56.88 years. Ninety one (32.2%) patients had a claudication discomfort (Fonten stadium II), 91 (32.2%) disabling claudication discomfort (Fonten stadium IIB), 45 (15.9%) rest pain (Fonten stadium III), and 56 (19.8%) gangrene (Fonten stadium IV). In 45 (15.9%) patients previous vascular procedures were performed. Prior to operation, Doppler ultrasonography and translumbar aortography were carried out (Figure 1). Transperitoneal approach to abdominal aorta, and standard inguinal approach to femoral arteries were used. In 154 (54.4%) patients proximal anastomosis had an end to side (TL), and in 129 (45.6%) end to end (TT) form. In 152 (26.88%) cases distal anastomosis was done in the common femoral (AFC) artery, and in 414 (73.2%) cases in the deep femoral (APF) artery. In 7 patients the aorto-femoro-popliteal "jumping" bypass was done, and in 29 patients simultaneous sequential femoro-popliteal bypass graft. The patients were following-up over the period from one, six and twelve months after operation, and later once a year, using physical examination and Doppler ultrasonography. In patients with suspected graft occlusion, anastomotic stenosis, pseudoaneurysms, progression of distal arterial diseases, Duplex ultrasonography and angiography were also used, and leukoscintigraphy in patients with suspected infection. Statistical analysis was performed using Long Rank and Student t-test. RESULTS: Inhospital mortality rate was 11 (7%). Distal reconstructions significantly increased the mortality rate when simultaneously performed with aortobifemoral bypass graft (p < 0.01). The follow-up period was from 2 months to 9.5 years (mean 3.6 years). The early patency rate was 97% from PTFE and 99.4% for Dacron grafts, while the late patency rate was 94.9% for PTFE and 96.6% for Dacron grafts. The type of the graft had no statistical influence on the early and late graft patency (p > 0.05) (Graphs 1, 2, 3). Six (2.1%) early unilateral limb occlusions were observed. Five patients had the PTFE and one the Dacron graft, without statistically significant difference (p > 0.05). The reasons for early graft occlusion were: stenosis of distal anastomosis in 3 patients, and pure run off in 3 patients. In 5 patients urgent reoperation (limb thrombectomy with profundoplasty or femoro-popliteal bypass graft above the knee) were done with complete recovery of legs. However, in one patient the above knee amputation was done. During the follow-up period, 14 (5.2%) late graft occlusions were recorded. There were 11 unilateral limb occlusions and 3 bilateral. All patients with bilateral occlusions had PTFE grafts but this was not statistically significant (p > 0.05) comparing two types of grafts. Taking into account all late occlusions, there were 7 PTFE and 7 Dacron grafts. There was no statistical difference betwe

Adult↗