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Biomedical subjects

G Pedersen

Publications and source records attributed to G Pedersen.

At least 73 records · Page 4Linked to original sources
PubMed1982

Chronic pancreatitis in Copenhagen. A retrospective study of 64 consecutive patients.

A longitudinal study of 64 patients with chronic pancreatitis is presented. The patients were followed up for a median period of 4 years. Pain was the dominant symptom in 43 of the patients, but only 5 patients had pancreatic resection because of pain. Alcoholism was the etiology in 45 patients. Complications were common: 34 patients developed steatorrhea and 29 diabetes. Two major groups of associated diseases contributed to a high morbidity in chronic pancreatitis: 24 patients presented with duodenal ulcer, and 8 developed malignant tumors. This number is significantly higher than expected in a matched population (P less than 0.01). Twenty-six of the patients died within the observation period from complications of chronic pancreatitis (38%), from malignant neoplasms (15%), or from other causes (46%). The calculated mortality rate after 7 years of observation was close to 50%. Most patients were recruited from the lower social classes, and most were unemployed. We conclude that chronic pancreatitis in Copenhagen is associated with a high morbidity, a high mortality, and a poor social prognosis.

Adolescent↗
PubMed1981

Nonsurgical internal biliary drainage by endoprosthesis.

Insertion of an endoprostheses for internal biliary drainage was attempted upon 150 patients with obstructive jaundice. It was successful in 123 patients, and 99 patients had permanent drainage with the endoprosthesis. The plasma bilirubin level became normal in 64 of the patients. The effect upon jaundice was equal to that in 43 patients who underwent operation with palliative surgical bypass. The median survival time was not different from that for the patients with surgical anastomoses. Twenty-eight patients died in the first month after insertion, mostly of advanced malignant disease. Fifteen of the patients in the group with surgical anastomoses died within the first month. The insertion of an endoprosthesis for bile duct obstruction is relatively easy and seems to have little risk. Most complications are caused by the transhepatic cholangiography procedure. The method may be used for temporary drainage before operation, in transient benign obstructions or as permanent drainage in unresectable lesions. In patients with dislodgement or insufficient function, additional endoprosthesis may be inserted. Thus, sufficient palliation of jaundice is achieved with a low frequency of cholangitis. Internal biliary drainage by insertion of an endoprosthesis is a valuable alternative to surgical bypass in patients with unresectable lesions.

Adult↗
PubMed1980

Plasma catecholamines, renin and aldosterone during combined alpha- and beta- adrenoceptor blockade in patients with severe arterial hypertension.

Arterial blood pressure and plasma catecholamines, renin activity and aldosterone concentration in 12 patients with severe essential hypertension were studied before and after combined alpha- and beta- adrenoceptor blockade induced by oral labetalol treatment for 2 months. Frusemide in a fixed dose was employed as a basic antihypertensive agent throughout the study. Blood pressure was adequately controlled in only 6 patients. Mean body weight increased by 1.8 kg and there was a rise in body weight which was inversely correlated with the fall in standing mean blood pressure. The mean plasma noradrenaline concentration decreased from 0.30 to 0.20 ng/ml, whereas plasma adrenaline did not change significantly. Plasma renin activity and aldosterone concentration varied greatly, but the mean values did not change significantly. Change in body weight was correlated inversely with changes in plasma noradrenaline and renin. The results suggest that labetalol, through its combined alpha- and beta- adrenoceptor blocking action, induces a rise in body weight, probably due to sodium and fluid retention, which partly counterbalances its anti-hypertensive effect and partly modifies both renin and sympathetic nervous activity.

Adult↗
PubMed1979

Effect of oral labetalol on plasma catecholamines, renin and aldosterone in patients with severe arterial hypertension.

Arterial blood pressure and plasma catecholamines, renin activity and aldosterone concentration in 12 patients with severe essential hypertension were studied before and after combined alpha- and beta-adrenergic receptor blockage induced by oral labetalol treatment for 2 months. Furosemide in a fixed dose was employed as a basic antihypertensive agent throughout the study. Blood pressure was adequately controlled in only 6 patients. Mean body weight increased by 1.8 kg and there was a rise in body weight which was inversely correlated with the fall in standing mean blood pressure. The mean plasma noradrenaline concentration decreased from 0.30 to 0.20 ng/ml, whereas plasma adrenaline did not change significantly. Plasma renin activity and aldosterone concentration varied greatly, but the mean values did not change significantly. Change in body weight was correlated inversely with changes in plasma noradrenaline and renin. The results suggest that labetalol, through its combined alpha- and beta-adrenergic receptor blocking action, induces a rise in body weight, probably due to sodium and fluid retention, which partly counterbalances the antihypertensive effect of labetalol, and partly modifies both renin and sympathetic nervous activity.

Adult↗
PubMed1979

Effect of propranolol on total exchangeable body potassium and total exchangeable body sodium in essential hypertension.

Total exchangeable body potassium (KE) was determined in fifteen patients with essential hypertension, and total exchangeable body sodium (NaE) in ten, before and after propranolol administration for 2-3 months. Blood pressure was reduced; serum potassium increased, but KE was unchanged. Serum sodium and NaE were unaffected during therapy. It is concluded that the increase in serum potassium during propranolol treatment could not be attributed to potassium retention, but is possibly due to a displacement from the intra- to the extracellular fluid compartment. The antihypertensive effect of propranolol could not be related to changes in NaE.

Adult↗
PubMed1977

Exact method for clinical measurement of loss of periodontal attachment.

The aim of the present investigation was to develop a clinical method for measuring loss of periodontal attachment, with a measuring unit of less than 1 mm, which did not require surgical intervention. The method was based upon impressions of the pocket area. Sixteen teeth on which the cementoenamel junction was situated below the gingival margin and which were scheduled for extraction for prosthetic reasons were used. Two impressions of the facial gingival pockets of each tooth were taken using steel strips dipped in Coe-flex and inserted at the bottom of the pocket. The loss of attachment in relation to the cementoenamel junction was measured in a stereomicroscope with a measuring unit of 0.04 mm. After extraction, the teeth were stained for connective tissue attachment and the loss of attachment was measured. Duplicate measurements and pre- and post-extraction measurements of the same situation were compared. The results show that the accuracy and reproducibility of the method is high.

Epithelial Attachment↗
PubMed1975

The value of the duodenal intubation method (sellink modification) for the radiological visualization of the small bowel.

X-ray examination of the small bowel was performed in 52 patients by means of the conventional barium meal as well as the duodenal intubation method - Sellink modification - as a comparative study. The visualization of the jejunum and ileum except the terminal ileum was significantly better by the Sellink method compared to the routine examination. The intubation modification seems to be a valuable diagnostic supplement.

Barium Sulfate↗