Biomedical subjects

G Pelù

Publications and source records attributed to G Pelù.

10 recordsLinked to original sources

PubMed1980

Radiation effects on the parotid gland of mammals. Part 4: Biochemical and morphological changes after local irradiation.

A morphological and biochemical study was done on rat parotids to evaluate the modifications after 2400 rad in the parotid area only. As previously observed, whole-body irradiation with lower doses produced only slight effects on the gland. The enzymes peculiar to glandular function decreased significantly 3 days after irradiation, later they fluctuated on control values. Increase in alkaline phosphatase, LAP, and decrease in protein content was a constant result. Beta-glucuronidase only among lysosomal enzymes increased significantly at some intervals. Morphological alterations in the glandular sections of the sacrificed animals appeared modest and mostly consisted of progressive fibrosis.

Alkaline Phosphatase↗

PubMed1979

Radiation effects on the parotid gland of mammals. Part 3: Behaviour of enzyme activity after irradiation.

Modifications of some enzyme activities in parotid tissue homogenates have been studied in animals which were also examined for morphological changes and for plasma and parotid amylase activity. Results from irradiated animals show a certain increase in maltase activity. Alkaline phosphatase and LAP show no significant variations; a similar behaviour is shown by lysosomal enzymes and protein content. A different pattern was seen by comparing the curves of these enzymes with those of the same activity in the small intestine. This result appears to be due to the different radiosensitivity of these tissues.

Alkaline Phosphatase↗

PubMed1979

Radiation effects on the parotid gland of mammals. Part 2: Modifications of plasma and parotid amylase activity.

The early modifications of the activity of plasma and parotid amylase have been evaluated in rats after whole-body irradiation in different experimental conditions. The modifications observed in the rat are less evident than in humans. The results have shown an initial decrease and a subsequent increase appearing significant 74 hours after irradiation. This could be due to a direct action of ionizing radiation on the parotid glands. However we cannot exclude that the increase of alpha-amylase could be determined by the intestinal radiation syndrome. In fact, this syndrome leads to a reduced food uptake, and consequently alpha-amylase could accumulate in parotids.

Amylases↗

PubMed1979

Radiation effects on the parotid gland of mammals. Part 1: Modifications on the morphology and uptake and elimination after 14C-leucine administration.

U-14C-Leucine uptake and eliminaton in connection with morphological investigations after sublethal doses have been studied. The tracer uptake and elimination curves do not show significant differences between controls and irradiated animals, except for early appearance of initial peaks. An increased uptake of labeled amino acid was observed only 32 and 120 hours after irradiation, when sacrifices were done at the same hours of the day. The dose employed does not seem to affect in any significant way either the acinar and duct cells or other structures. Only a mild thickening of the connective tissue has been observed in the parotid of animals sacrificed at longer intervals.

Animals↗

PubMed1974