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Biomedical subjects

G Pellicanò

Publications and source records attributed to G Pellicanò.

9 recordsLinked to original sources
PubMed1994

Quantitation of brain perfusion with 99mTc-bicisate and single SPECT scan: comparison with microsphere measurements.

This study describes and validates in a preliminary manner a method to measure the steady-state influx constant (Ki) of 99mTc-bicisate with one single photon emission computed tomography (SPECT) scan. The method is based on the analysis of the arterial concentration of the radioactivity. The results of this quantitation procedure were compared with regional CBF (rCBF) measurements made using 99mTc-microspheres (MI). Two quantitative indexes of perfusion, fractional brain uptake (FBU) and normalized (with cerebellum) brain uptake (NBU), were also evaluated. Two SPECT studies were performed on seven cardiovascular patients who had no signs of neurological disease. In the first of these, 99mTc-bicisate was used, while in the other, which was performed 2 days later, MI were injected into the left heart ventricle. The values of the FBU, NBU, and Ki of 99mTc-bicisate were calculated in several gray and white matter brain regions of interest (ROIs) and compared with the rCBF values measured with MI in coupled ROIs. Mean FBU values were 0.00008 +/- 0.00002 and 0.00004 +/- 0.00001 in the gray and the white matter, respectively. Mean NBU values were 0.99 +/- 0.04 and 0.54 +/- 0.05, mean Ki values were 0.36 +/- 0.06 and 0.19 +/- 0.03 ml g-1 min-1 and mean rCBF values were 0.51 +/- 0.04 and 0.27 +/- 0.04 ml g-1 min-1 in gray and white matter, respectively. Analysis of variance of the regression gave different F values for the regressions with rCBF of FBU (F = 19, n = 126), NBU (F = 289, n = 112), and Ki (F = 117, n = 126).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1993

[Computer-assisted interactive didactic system in radiology].

A computer-assisted didactic interactive system for radiology is described; it was implemented on a widely available, cost-effective personal computer with advanced graphic features. A set of suitable CT images was selected and digitized with a specific software that also allowed to process the acquired images. After adding graphic and textual comments, the images were ready to be put in the tutorial. A second software tool was used to manage the image display and to control the correct sequence of the interactive steps of the tutorial. A series of computer-driven multiple-choice questions was prepared to provide the user with a tool improving his/her knowledge of the topics covered by the system, in a simple and unconventional way. The tutorial was designed so that both the absolute number and the percentage of correct answers can be displayed and the critical evaluation of incorrect answers is automatically performed; in the end, the system goes back to the first screen and the tutorial can be run again. The system performance is good with standard hardware; it can be markedly improved with the integration of peripherals--i.e. hard disk. In the next future, the commercial availability of more advanced storage media (videodisks and optical disks) will dramatically improve the archiving capacity and will reduce access times.

Computer-Assisted Instruction↗
PubMed1990

[Side effects of spinal nerve root radiography. How to reduce them?].

Contrastographic techniques with intrathecal injections (SRG, Myelo-CT) are widely employed in the diagnostic approach to lumbar pathologic conditions. These techniques allow pathologic changes to be demonstrated and the information they yield helps plan the correct surgical approach. However, these invasive examinations are seldom employed for the high incidence of side-effects. The latter are related to various causes, the identification of which can help reduce the side-effects themselves. The authors analyzed a study population of 522 patients subjected to radiculography, using needles of different gauges (18-23 G), and injected non-ionic contrast medium in doses ranging 5-10 ml. The incidence of side-effects was significantly higher in the patients suffering from usual headache (79/237 = 33%), in those under 40 (87/238 = 37%), and in female patients (86/221 = 39%). The incidence of side-effects was lower with fine needles (41/139 = 17%) and contrast medium in doses less than 8 ml (80/337 = 24%). The patients were divided into 4 subgroups according to the different doses of contrast medium administered and to needle gauges: the above parameters exhibited a percentage decrease (21/161 = 14%) with 21-23 G needles and 8 ml of contrast medium. The authors believe it possible to reduce side-effects by using fine needles and smaller doses of contrast medium.

Adolescent↗
PubMed1989

[Vertebral osteochondroma and trauma: a possible etiopathogenic correlation].

Three cases of vertebral osteochondroma are shown. The tumor was localized in the dorsal tract in two cases and in the lumbo-sacral junction in the other one. We found in all the cases, as a common anamnestic point, a clinical history of trauma. The etiopathological hypotheses are discussed and the hypothesis of a possible correlation between trauma and metaplastic osteochondromatosis is presented.

Adult↗
PubMedDate not supplied

[Ultrasonography and computerized tomography in giant Baker's cyst].

The US study of the posterior compartment of the knee usually allows the clinical suspicion of popliteal cyst to be confirmed. Nevertheless, in case of giant Baker's cysts--which are, at any rate, less frequent--US diagnosis is more difficult. CT can help determine the benign nature of the lesion, and allow an accurate spatial evaluation. Moreover CT, when accurately performed, demonstrates the caudal or cranial cystic spread, together with its clear separation from adjacent muscular tissues. Direct coronal scans are more useful to obtain better spatial definition than reformatted images.

Humans↗
PubMedDate not supplied

For an elective surgical management in lumbar intervertebral disc herniation. Experience of 25 years of surgery.

On the base of a wide clinical experiences, the Authors report some consideration about relationship between clinical findings and neuroradiological pictures (plain film, myelography, CT and NMR) of the lumbar vertebral and disc diseases. It's pointed out the useful aspect of each imaging technique that contribute to obtain the more complete informations about anatomy of the lesion; such considerations allows the surgeon to plain the more adequate surgical technique. The Authors think myelography, still today, is the investigation of choice in this kind of pathology.

Adult↗
PubMedDate not supplied

Magnetic resonance in the study of cranial nerves.

The course of cranial nerves was studied by means of magnetic resonance (MR), which allowed a multiplane visualization of the investigated structures. The obtained results showed that MR was an excellent method for visualization of the optic, trigeminal, facial and acoustica nerves. The oculomotor and the abducent nerves were detectable only in some regions where the contrast with the surrounding structures was greater. The glossopharingeus, vegus and accessory nerves were identifiable only in the first tract of emergency from the encephalic trunk and they could no be distinguished separately. The trochlear nerve was seldom visible whereas the olfactory nerve failed to be revealed. Further technological progress will allow for additional advances as regards the acquisition of knowledge concerning these important nerves.

Adult↗