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Biomedical subjects

G Pelusi

Publications and source records attributed to G Pelusi.

At least 19 recordsLinked to original sources
PubMed1992

Ag-NOR protein distribution correlates with patient survival in stage I endometrial adenocarcinoma.

The relationship between argyrophil nucleolar organizer region (Ag-NOR) protein quantity and prognosis was studied in 33 cases of stage I endometrial adenocarcinoma. Ag-NOR protein quantity was measured by image analysis in silver-stained sections from paraffin-embedded samples of curettings. Patients had a minimum 10-year follow-up. Only 2 out of 25 patients exhibiting a mean Ag-NOR protein area of less than 3 microns2 died of cancer, whereas 5 of the 8 patients with a mean Ag-NOR protein area of more than 3 microns2 died of the disease. The present results demonstrate that the Ag-NOR protein value is closely related to patient survival in stage I endometrial carcinoma and that it is a reliable prognostic indicator in this type of carcinoma.

Adenocarcinoma↗
PubMed1991

Evolution of the indications for cesarean section. Results of a retrospective study.

We have analysed in retrospect the incidence of cesarean section during the years 1977-1989 in the 1st Obstetric and Gynecologic Clinic of the University of Bologna, and the development over time of the principal indications. The average incidence (17.1%) of cesarean section increased progressively from 9% in 1977 to 28% in 1989 with a peak at the beginning of the '80s (the period during which cardiotocographic monitoring became routinely used). With regard to the indications from 1977 up to date cesarean sections carried out on account of fetal distress increased almost five-fold. The increase in cesarean sections carried out on account of maternal disease, breech presentation and previous cesarean section was less important, while those performed for dystocia resulted markedly reduced.

Adult↗
PubMed1990

Increased placental production of leukotriene B4 in gestational hypertension.

Production of some lipoxygenase and cyclooxygenase derivatives of arachidonic acid was measured in placental tissue obtained from women with gestational hypertension and with normal pregnancies. The levels of leukotriene B4 were about five times higher in placentas from hypertensive women and also raised thromboxane A2 and reduced prostaglandin E2 levels were observed. Prostacyclin production was lowered only in women with more severe hypertension, in association with the highest measured levels of leukotriene B4 and thromboxane A2. It is suggested that increased placental levels of leukotriene B4 and thromboxane A2 appear already in mild gestational hypertension, while depression of prostacyclin may occur only at more severe stages of gestational hypertensive disease.

Adult↗
PubMed1989

Brenner tumor of the ovary: a correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation.

The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuron-specific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.

Brenner Tumor↗
PubMed1984

Morphofunctional findings in adenocarcinoma of endometrium.

Ten cases of adenocarcinoma of the endometrium were studied using histochemical methods for mucopolysaccharides and immunocytochemical methods for the localization of various markers, such as EMA (epithelial membrane antigen), GCDFP-15 (gross cystic disease fluid protein) and CEA. Four cases appeared to contain High Iron Diamine-positive substance and 6 cases were positive using an immunocytochemical method with a polyclonal anti-CEA antiserum. In contrast, no cases stained when a monoclonal anti-CEA antiserum was employed. This suggested that HID- positive material could be a sign of differentiation towards cells with a secretory function.

Adenocarcinoma↗
PubMed1984

Morpho-functional changes in normal cyclic endometrium.

Eight cases of normal endometrium in the early proliferative phase and an equal number of cases in the late secretive phase were stained histochemically for acidic mucosubstances and immunocytochemically for epithelial membrane antigen (EMA), carcinoembryogenetic antigen (CEA) and Gross Cyst Disease Fluid Protein -15 (GCDFP-15) production. Alcian blue positive material was observed in both phases of the cycle, although the distribution was different. Sulphated mucosubstances were only present in the secretive phase. No CEA nor GCDFP-15 immunoreactive material was detected. EMA positive staining was observed in all cases, but the distribution varied according to the two different phases of the cycle.

Adult↗
PubMed1983

Sclerosing stromal tumor of the ovary. A hormonal, histochemical and ultrastructural study.

Three new cases of sclerosing stromal tumor of the ovary have been studied by hormonal, immunohistochemical and electron microscopic analysis. The results confirm that this tumor may have hormonal activity. Ultrastructural study shows findings different from those previously reported. The authors propose an origin from the ovarian stroma with luteinization of stromal tumor cells.

Adolescent↗
PubMed1983

Behavior of some steroids in endometrial adenomatous and atypical hyperplasia.

Endometrial adenomatous and atypical hyperplasia are the histopathological pictures that more frequently may develop into an adenocarcinoma. It is believed that a hormonal action may favour the genesis of endometrial cancer. We studied the plasmatic levels of some steroids, considered to be responsible for neoplastic changes, in patients with adenomatous and atypical hyperplasia. With this object we measured plasmatic levels of estrone, estradiol, androstenedione, DHEA-S and testosterone in postmenopausal patients with adenomatous and atypical hyperplasia and in fertile women, both in proliferative and secretory phases. We didn't find any difference in the steroid pattern in the two groups.

Adult↗
PubMed1983

Behaviour of some steroids in postmenopausal women with coelomic ovarian tumors.

In order to study the hormonal pattern in ten postmenopausal women with coelomic ovarian tumors we measured Estrone, Androstenedione, DHEA-S and Testosterone plasmatic levels before and after surgery. Estrone and Androstenedione plasmatic levels were significantly higher in patients with coelomic ovarian tumors than in the control group and they showed a rapid and constant decrease after surgery. Nevertheless we didn't find any ovarian histological picture to explain the hormonal increase.

Adenocarcinoma, Mucinous↗