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Biomedical subjects

G Pelzer

Publications and source records attributed to G Pelzer.

7 recordsLinked to original sources
PubMed1991

Identification and characterization of 19-nortestosterone in urine of meat-producing animals.

To monitor the illegal use of 19-nortestosterone as an anabolizing agent in meat-production, the Belgian Institute of Veterinary Expertise applies a strategy of urine control by radioimmunoassay, positive samples being confirmed by thin-layer chromatography. We have evaluated this control strategy, using gas chromatography-mass spectrometry to confirm the presence of 19-nortestosterone, or its metabolite oestrane-diol, in positive samples from radioimmunoassay. Our results show that the effective way of proceeding remains reliable in cattle, for mature and immature males as well as non-pregnant females, and in pigs, for pregnant and non-pregnant sows. The possible presence of endogenous 19-nortestosterone in cattle, in pregnant cows urine, and in pigs, in boars and in cryptorchid pigs, impedes the control of the use of 19-nortestosterone on these samples. False-positive (not confirmed by gas chromatography-mass spectrometry) results were produced by radioimmunoassay in the urine of castrated pigs and sheep.

Animals↗
PubMed1991

Anabolics: the situation in Belgium.

The illegal use of anabolics in 1989-1990 and its control in Belgium are reviewed. After a short presentation of the Belgian legislation and EEC directives, a recent hormone scandal published by a consumer magazine is related and the composition of 17 hormone cocktails found on the black market is given. The strategy of control involves screening of the main artificial anabolics in urine by radioimmunoassay (RIA) and confirmation by thin-layer chromatography (TLC). Samples of fat and injection sites are also examined by TLC. In the future, RIA will probably be replaced by enzyme immunoassay and TLC by mass spectrometry.

Anabolic Agents↗
PubMed1989

Normal values for human umbilical venous and amniotic fluid pressures and their alteration by fetal disease.

Umbilical venous and amniotic fluid pressures were measured in 68 human pregnancies at the time that cordocentesis was performed. Normal umbilical venous pressure was unrelated to gestational age and remained within a tight range (5.3 +/- 2.3 mm Hg, mean +/- SD). Fetuses with an elevated umbilical venous pressure had disorders consistent with either hepatomegaly or congestive heart failure. Umbilical venous pressure was significantly increased before treatment in two fetuses with immune hydrops; it rapidly declined with treatment. Neither gestational age nor umbilical venous pressure was significantly different in the groups that received and did not receive pancuronium. There was a strong relationship between amniotic fluid pressure and gestational age in normal pregnancy (r = 0.54, p less than 0.0001). Women with hydramnios had amniotic fluid pressures greater than control subjects (p = 0.0007). This investigation documents normal human amniotic fluid and fetal umbilical venous pressures. These measurements are altered by disease and may prove to be of diagnostic and therapeutic value in the future.

Amniotic Fluid↗
PubMed1984

On the influence of hydrophobicity in the SIMS spectra of amino acids in glycerol matrix.

Mass spectrometry is becoming an important method in structure determination of biopolymers. Determination of the nature and the number of the various monomers is an important information for the elucidation of fragmentation patterns. We present here a matrix designed to allow both identification and semi-quantitative measurement of amino acids residues in peptides.

Amino Acids↗