Biomedical subjects
Publications and source records attributed to G Pichon.
The authors compare the serological results obtained before and after a single dose with diethylcarbamazine (6 mg./kg.) in a homogeneous and strongly infected with Wuchereria bancrofti var, pacifica population. They point out a statistically significant decrease of the hemagglutining antibody titres of filarian patients.
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Authors describe an extensive outbreak of dengue 4 virus which is observed for the first time out of its Asian original focus. The whole archipelagos of French Polynesia have been contaminated in a space of four months. Usual form of the disease is typical with lightness of the symptoms. This outbreak has been implicated in the death of a child by shock; and two cases of reversible encephalitis have been certainly caused by this virus. The neurotropism is the main characteristic of dengue virus type 4.
Authors report some accurate epidemiologic and physiopathologic data about dengue 4. Thanks to virus intrathoracic inoculation in Toxorhynchites amboinensis (Doleshall, 1857), 202 viral strains have been isolated from 633 sera samples. The incidence of the disease has decreased very early after immunization of the whole population and resulted in an eradication of dengue type 1 virus which was endemic in French Polynesia since 1976. Only one type of dengue virus seems to be tolerated in French Polynesian ecosystem in the same time. There is no crossing protection with dengue 1. Clinically, the picture has been the same in both new and previously infected by dengue 1 patients. Duration of viremia during the secondary dengue fever is not shorter than in the primary one. The hemagglutination inhibiting antibodies do not protect patients, but do not result in immune-complexes pathology.
A statistical analysis was conducted, in order to compare the variations in values of a) blood samples obtained with several finger-pricks from the same individual in a short period of time, and b) blood samples obtained from the same finger-puncture. No significant difference was observed: both groups seem to follow a negative binomial distribution, the exponent of which is not dependent on the microfilarial count average. This common exponent is roughly equal to the volume of the blood sample, expressed in cmm.