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G Piel

Publications and source records attributed to G Piel.

23 records · Page 2Linked to original sources
PubMedDate not supplied

A comparative study of the antimycotic activity of a miconazole HP-beta cyclodextrin solution and a surfactant solution.

The antimycotic activity of a new parenteral solution containing miconazole was compared to that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the belgian market probably because of the toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing 10 mg of miconazole per ml (as the marketed solution), in combination with HP-beta cyclodextrin and lactic acid. The MIC of these two solutions were determined by broth microdilution method (following the NCCLS guidelines) against 15 yeasts and 16 filamentous fungi isolates. This study showed that MIC obtained with these two solutions are not significantly different. In vitro, the cyclodextrin solution has the same antimycotic activity as the Daktarin IV solution and can be proposed as a safe and effective parenteral solution to replace the previous surfactant solution.

Antifungal Agents↗
PubMedDate not supplied

Inclusion of piroxicam into beta-cyclodextrin by means of supercritical carbon dioxide: thermal, spectroscopic and physicochemical studies.

The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. The solubility piroxicam in supercritical CO2 was determined. The influence of the temperature, the pressure and the time of exposure on the inclusion rate were studied and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 150 bar of CO2. This complex was characterised by Differential Scanning Calorimetry and Fourier Transform Infrared Spectrometry. Supercritical carbon dioxide may prove to be a novel useful complexation method of non-polar drugs into beta-cyclodextrin.

Carbon Dioxide↗