Leukaemia - a brief historical review from ancient times to 1950.
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Biomedical subjects
Publications and source records attributed to G Piller.
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Manufacture of an Ayurvedic arsenic-containing compound is described, which is currently in use in India to control blood counts of patients with haematological malignancies. The efficacy and side effects of this compound are evaluated in the light of the fact that arsenic was recognised to be of use in the control of blood counts from patients with chronic myeloid leukaemia as long as 100 years ago, in the West.
A brief review of the history of human leukemia, first identified as a new disease in 1845, is given as a personal perspective related to the re-examination of dogmas surrounding the disease. The paper addresses the question of what kind of disease leukemia is, and how far the adherence to dogma has shaped the firm belief that leukemia is a malignancy.
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Further biochemical investigations were performed in a case of glucose-6-phosphate dehydrogenase deficiency--called the "Vienna" deficiency variant on account of its biochemical characterization. It was found that the "Vienna" deficiency variant shows increased enzyme protein at a reduced specific activity. Gel filtration on Sephadex-G-200 produced a molecular weight identical with that of the normoenzyme; the different cochromatographic behaviour on hydroxylapatite appears attributable to a sequence modification of the amino acids.
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