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Biomedical subjects

G Pilz

Publications and source records attributed to G Pilz.

At least 19 recordsLinked to original sources
PubMed1992

Early prediction of septic complications after cardiac surgery by APACHE II score.

In 110 patients admitted to the intensive care unit after cardiac surgery, daily monitoring [clinical parameters, cardiac index (CI), left ventricular stroke work index (LVSWI) and APACHE II score] was performed in regard to its usefulness in the early prediction of septic complications, a major cause of postoperative mortality. Septic complications (defined as Elebute sepsis score of > or = 12 on > or = 2 days) occurred in 16 patients and were associated with a significantly worse prognosis (mortality 69% vs 1%, P < 0.0001) than was seen in patients without sepsis. While preoperative APACHE II score values did not differentiate between the patients with an uneventful postoperative course and those with septic complications, patients who ultimately developed septic complications had significantly (P < 0.001) higher scores as early as on the evening of the operation day ("day 0"). In addition, in contrast to patients without sepsis, whose scores dropped markedly (P < 0.001) between day 0 and day 1, patients with septic complications invariably had high scores. Compared to single parameters (fever, leucocyte count, CI, LVSWI), the APACHE II score proved to be superior in differentiating between patients who developed sepsis and those who did not. A score of 19 or more on the 1st postoperative day had a sensitivity of 75%, a specificity of 98%, a Youden index of 0.73, a positive predictive value of 86%, and a negative predictive value of 96% in regard to prediction of septic complications.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiac Surgical Procedures↗
PubMed1991

A basic program for calculation of APACHE II and Elebute scores and sepsis evaluation in intensive care medicine.

This paper describes a program for bedside-practicable calculation of APACHE II score, providing an additional option for both a rapid and sensitive screening as well as for a more specific sepsis assessment by the Elebute score in case of a putative diagnosis of sepsis. Thus, diagnostic and prognostic evaluation of septic patients and the assessment of disease progression and classification of "responders" to therapy can be promptly available in the ICU setting. The program is written in BASIC and therefore can easily be adapted to most microcomputers available on the market.

Bacterial Infections↗
PubMed1991

[Supplemental infection therapy with i.v. immunoglobulins (polyvalent IgG and Pseudomonas IgG)--results of an observational case study with 163 patients].

The impact of i.v. immunoglobulin (IVIG) therapy on the survival of adult septic patients cannot yet be considered either proved or disproved. To define optimal criteria for a large multicenter placebo-controlled trial, a multicenter observational study was carried out in 163 medical and surgical patients exhibiting a total of 173 episodes of sepsis and septic shock [Elebute (El) sepsis score; 19 +/- 0.5). The effects of supplemental IVIG treatment (unmodified polyvalent IgG, pH 4.25, n = 123; for Pseudomonas sepsis, n = 50, Pseudomonas IgG) on multiple-organ failure (MOF) were investigated according to changes in the APACHE II score (AP) (pretreatment value 23.7 +/- 0.6). In 44% of the cases ("responders"), a prompt improvement in AP (defined as a decrease of greater than or equal to 4) was evident from day 0 to day 4 after the onset of therapy, thus showing a close temporal relationship to IVIG administration. This improvement, associated with an improved prognosis (mortality, 24% vs 55%), was found in all subgroups, most importantly, polyvalent IgG vs Pseudomonas IgG treatment; medical vs surgical patients; moderate vs severe MOF; and gram-positive vs gram-negative septicemia. Thus, all of these patients should be included in future placebo-controlled, randomized IVIG trials.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

GZ 100, 101, 106, 107, 111, 112, 116, 121: a series of monoclonal antibodies against human trophoblast antigens.

The GZ100 series comprises a panel of monoclonal antibodies which seem to be specific for human trophoblast antigens (with the exception of GZ111, which reacts with a number of other tissues). The GZ antibodies show different reaction patterns with different trophoblast cell types. As a panel the GZ antibodies recognize all trophoblast populations (Table 2). Thus these antibodies provide a means to distinguish between trophoblast cells and maternal cells. GZ112 might be used to sort out HLA-class I positive trophoblast cells of the basal plate without blocking the HLA antigenic determinant, since GZ112 is not an anti HLA-class I antibody. At present the antigens detected by the GZ antibodies seem to be proteins, most of them with molecular weights between 50 kD and 80 kD. The function of these antigens is unclear and will be studied in future.

Animals↗
PubMed1989

[Use of pseudomonas immunoglobulin. Indications and results].

In comparison with polyvalent immunoglobulins, Pseudomonas immunoglobulin (Psomaglobin) is enriched several times in antibodies to Ps. lipopolysaccharide antigens and exotoxin A as well as lipid A. The resulting protective action which is superior to polyvalent immunoglobulins in infections with Pseudomonas, was demonstrated both in cell culture (protection against cytotoxicity of Ps. exotoxin A in heart muscle cells) and in animal models of sepsis. In patients suffering from Ps. pneumonia and Ps.-sepsis clinical improvement is seen after application of this immunoglobulin and also in quantifiable by scoring systems, the unequivocal proof of lowering lethality by using this specific immunoglobulin in Pseudomonas infection is to be shown however.

Critical Care↗
PubMed1989

[Sonographic studies in odontogenic maxillary sinus diseases].

Clinical diagnostic information was analysed and compared with conventional x-ray and B-scan examination in 90 patients with maxillary sinus diseases of dental origin. In certain diseases (sinusitis, cysts) the ultrasonic sonography offered little additional clinical-relevant information. On the other hand this modern noninvasive, picture yielding and ever reproducible method is predestined for objective confirmation of the late complaint after maxillary sinus operation. But the high apparatus technical investment limits its application in large scale.

Adolescent↗
PubMed1979

[Late recurrence of ameloblastoma].

Two cases of late recurrence (31 and 33 years after radical surgery) of an ameloblastoma induced us to explain our operative approach on the basis of experience with 37 patients operated on for ameloblastoma at our clinic. With special consideration of the biology, clinic and histopathology of this tumour, we have tried to establish operative guidelines with regard to radical surgery. We arrived at the conclusion that ameloblastomas regarded as malignant should be treated by radical surgery; and those considered to be benign, by conservative surgery, individual decisions being imperative. Our clinical observations and analyses are compared with the results of other authors.

Ameloblastoma↗
PubMed1978

[Therapeutic aspects of odontogenic maxillary sinusitis].

On the basis of observations in 90 patients with odontogenic maxillary sinusitis who had been re-examined clinically and radiologically, the authors deal with the optimal utilization of all possibilities of conservative treatment. 74% of the patients were symptom-free, 55% presented a radiologically well pneumatized sinus. The healing quality of inflammatory alterations of the sinusal mucosa is once again confirmed by the observation of the course of the disease.

Anti-Bacterial Agents↗