Biomedical subjects

G Piros

Publications and source records attributed to G Piros.

4 recordsLinked to original sources

PubMed1991

[The significance of the dipyramidole echocardiography test in ischemic heart disease].

The diagnostic value of the dipyridamole echocardiography test was investigated in 46 patients who underwent coronary angiography due to suspected ischaemic heart disease. Twenty-two of 46 patients were found to have a narrowing of at least 70% one vessel. Twenty-four hour ECG monitoring was also performed on 19 patients on the day of the dipyridamole test. The sensitivity and specificity of the two-dimensional echocardiography test (new wall motion abnormality) were 72.7% and 62.5%. The ECG (V2-5-9) had a low sensitivity during the test (43.8%). Good agreement was found between the localization of the wall motion abnormalities and the site of anatomic narrowing in the ischaemic group. No significant ventricular arrhythmias were detected, and the sensitivity and specificity of ST-T changes were found to be 62.5% and 54.6% by means of Holter monitoring. The dipyridamole echocardiography test proved to be a suitable noninvasive method for the diagnosis of ischaemic heart disease and for the selection of patients for coronary angiography.

Coronary Angiography↗

PubMed1986

Effects of long term alcohol ingestion on glutathione metabolising enzymes and taurine contents in the myocardium of rats.

The effects of long term intake of dietary alcohol on myocardial glutathione metabolism and taurine content were studied in rats. Alcohol, comprising more than 30% of the dietary calorie content, was administered to male CFY rats for six weeks. Compared with the controls, the left ventricle of the alcohol treated animals had an increased taurine content (18.4(2.6) vs 13.1(2.5) mumol X g wet weight-1) and a slightly, but not significantly, decreased reduced glutathione content. To assess the glutathione metabolism in the myocardium, the activities of glutathione reductase, glutathione peroxidase, glutathione-S-transferase, gamma-glutamylcysteine synthetase, and glutathione synthetase were measured. Significant increases were found in the activities of glutathione reductase (0.65(0.03) U.g wet weight-1 in the controls and 0.80(0.05) U.g wet weight-1 in the alcohol treated rats) and glutathione-peroxidase after six weeks of alcohol ingestion. Only slight, non-significant changes were found for the other enzymes investigated. It is thus apparent that in the myocardium of rats treated long term with ethanol the previously observed enhanced lipoperoxidation is not necessarily associated with severe glutathione depletion, and an increase in the activity of glutathione reductase might be responsible, at least in part, for the preservation of glutathione.

Alcoholism↗

PubMed1986

Extracorporeal shock wave lithotripsy: interventional radiologic solutions to associated problems.

Among 1,500 patients treated with extracorporeal shock wave lithotripsy, 1,300 had calculi less than 2.5 cm in diameter and 200 had calculi of 2.5 cm or larger. Although most patients did well and required no further radiologic intervention, 178 interventional radiologic procedures were performed. Urinary tract obstruction often developed in patients with large stones when the collecting system filled with stone fragments (steinstrasse). Nephrostomy was performed in 5.3% of the total patient population and in 29% of the patients with stones measuring 2.5 cm or more. Only 1.8% of the patients with calculi smaller than 2.5 cm required radiologic intervention. When the obstructed collecting system could not be crossed with conventional angiographic techniques, the stone fragments were removed through a percutaneous nephrostomy tract either by flushing or by suctioning with a pulsating water jet.

Humans↗

PubMedDate not supplied

Alcohol-induced congestive cardiomyopathy in adult turkeys: effects on myocardial antioxidant defence systems.

The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-invasive evaluation of left ventricular function by echocardiography revealed an impaired contractile function (the calculated fractional shortening values were 31.1 +/- 4.1% in the alcoholic group and 38.8 +/- 4.4% in the controls) and dilatation of the heart in the alcoholic birds. The changes in the non-invasive parameters of the left ventricle indicate that the adult Nicholas turkey developed congestive cardiomyopathy secondary to the ingestion of ethanol. In the hearts of normal adult turkeys, high GSH content (2.39 +/- 0.25 mumol/g wet weight) and superoxide dismutase activity were found, as compared to other animals, indicating the relatively higher development of antioxidant defence systems. Compared to the controls, significant increases were noted for all the antioxidant enzymes investigated (superoxide dismutase, catalase and glutathione peroxidase) and a moderately significant decrease in the GSH content was found in the left ventricle of alcoholic birds. The changes in GSH concentration and antioxidant enzyme activities might indirectly indicate some involvement of free radicals in the pathogenesis of ethanol-induced myocardial lesion. However, the levels of in vivo lipoperoxidation in the alcoholic birds did not significantly vary from those of control turkeys. Based on these findings, it appears that the reactive oxygen radicals may play a less important role in the pathogenesis of alcohol-induced cardiomyopathy in turkeys--probably due to the higher development of myocardial antioxidant defence systems.

Alcoholism↗