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Biomedical subjects

G Pisano

Publications and source records attributed to G Pisano.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Recovery after amputation for arteriosclerosis. Follow-up study].

Clinical follow-up of 71 patients subjected to major amputation of the lower extremities for atherosclerotic arteriopathy has been analysed for the purpose of ascertaining real possibilities of functional recovery and quality of life. Research results show that only a small number of patients (38%) can achieve an acceptable quality of life. The reasons have been identified in the objective difficulty of adequate physical and psychotherapeutic rehabilitation owing to structural shortcomings or the presence of associated pathology or the advance in the basic condition which does not permit application or frustrates results.

Adult↗
PubMed1991

Cholangiocarcinoma in a type III choledochal cyst.

We present the case of an 85 year old woman who was found to have a type III choledochal cyst with cholangiocarcinoma. The case is unusual because of the advanced age of the patient, the presence of both stones and a carcinoma in a type III cyst, and the associated congenital abnormalities.

Adenocarcinoma↗
PubMed1991

[Local recurrence caused by direct implantation from cancer of the colon; findings of a case report].

The Authors report the case of a 60 year old woman who developed a local recurrence 3 months after a right hemicolectomy for a cancer of the ascending colon. The site of the recurrence along the suture line, the huge size of the tumor, the short interval from the first operation with its apparent radicality strongly support the origin of such recurrence from implantation. Pathogenetic mechanisms of local recurrence due to implantation metastases as well as current methods to prevent tumor seeding in colorectal surgery are reviewed. The importance of early endoscopic follow-up after colorectal resection is also stressed.

Carcinoma↗
PubMed1990

Epidermal growth factor receptor and thyrotropin response in human thyroid tissues.

The content of epidermal-growth-factor receptor (EGFr) and its relation to TSH-response were examined in 27 malignant thyroid tumors (5 follicular, 6 papillary, 5 medullary, 11 anaplastic carcinomas) and in 30 tumor-like lesions (21 hyperplastic goiters and 9 toxic adenomatous goiters). Normal 12 thyroid tissues adjacent to benign tumors with no evidence of macroscopic or microscopic abnormalities were used as control. All thyroid plasma membranes tested showed specific EGF binding. In membranes from toxic adenomas (2.18 +/- 0.73 fmoles/mg protein) and papillary carcinomas (2.80 +/- 0.80) the EGF binding was similar to that of normal thyroid membranes (2.32 +/- 0.73). Hyperplastic goiters showed an EGF binding (4.4 +/- 0.82) slightly higher than normal tissue. The highest and the lowest EGF binding values were found in anaplastic (11.8 +/- 2.78) and medullary (0.50 +/- 0.39) carcinomas, respectively. An inverse correlation between EGFr content and TSH-response was found when anaplastic thyroid tumors were compared to tumor-like lesions. However no correlation was observed in medullary carcinomas which also failed to respond to TSH and in papillary carcinomas which partially respond to thyrotropin.

Cell Membrane↗
PubMed1990

Gangliosides and phospholipids in human thyroids responsive and unresponsive to thyrotropin.

The patterns of gangliosides and phospholipids and their relation to TSH response were examined in twenty-six malignant thyroid tumors (4 follicular, 6 papillary, 5 medullary, 11 anaplastic carcinomas) and thirty-six hyperplastic goiters. Thirteen thyroid tissues adjacent to benign tumors with no evidence of macroscopic or microscopic abnormalities were used as normal tissue. In normal thyroids the major ganglioside was GD3 (44%) and GM3 was the second ganglioside (20%). In minor amounts GD1a (8.6%), GD1b (6.2%), GT1b (5.7%) and GM1 (5.6%) were present. In hyperplastic goiters and in follicular carcinomas the patterns of gangliosides were similar to that of normal tissue except for GM3 which, in the last tissue, was higher (34%). In papillary carcinomas low levels of GM3 (11%) and GT1b (0.8%) with a high level of GD1b (12.6%) were found. In anaplastic carcinomas GM3 was very high (47%) whereas GD3 was low (18%). In these tumors also a high percentage (14.0%) of GD1a was found. In medullary carcinomas the lowest levels of GM3 (4%) with the highest level of GD3 (64%) were found. Although large differences of the gangliosides distribution were clearly encountered in the various pathological human thyroid, no correlation between lack of TSH response and some individual ganglioside could be made. No differences in the individual phospholipid in the various tissues studied were found.

Adenocarcinoma↗
PubMed1990

Famotidine in the management of acid-reflux oesophagitis: a multicentre study.

The management of gastro-oesophageal reflux still presents a considerable problem mostly because of its multifactorial pathogenesis. In this study, we tested the response to treatment with famotidine for 8 weeks in patients with reflux oesophagitis, taking into consideration, however, only cases with pathological gastro-oesophageal reflux of the acidic type. All the patients participating in the multicentre study underwent gastro-oesophageal 24-hr pH-metry. The results show a good response to the H2 antagonist treatment with regards to both symptomatology (improvement/healing in 98% of cases, asymptomatic in 68%) and the endoscopic and histological picture. In fact, endoscopy showed complete remission of the lesions in 60% of cases and an improvement in 21%. The histological picture of oesophagitis improved in 64% of cases, 36% of which were completely healed, with no modifications in the remaining 36%. These data, which are globally better than those reported in the literature, can probably be attributed to the original selection of patients treated by means of prolonged gastro-oesophageal pH-metry, who had exclusively pathological gastro-oesophageal reflux of the acidic type. For these patients the use of the H2 antagonist drug is more appropriate even as monotherapy, than it is for those patients who have combined or isolated alkaline gastrooesophageal reflux.

Adult↗
PubMed1990

[Chronic gastritis. A study of 151 cases diagnosed using gastric biopsy].

With the aim to detect a correlation between endoscopic aspects and histological features of chronic gastritis, the Authors have analysed retrospectively a series of 151 cases where endoscopic alterations were likely due to chronic gastritis and in all cases multiple biopsies were performed. A possible correlation between endoscopy, histology and occurrence of intestinal metaplasia has been carefully evaluated. Only in chronic atrophic gastritis a certain relationship between endoscopic features and histologic diagnosis was detectable: in the same cases a high incidence of intestinal metaplasia was found as well, independently from the severity of endoscopic and/or histologic aspects. The Authors discuss the controversial problems in terminology and endoscopic definition of chronic gastritis.

Adolescent↗
PubMed1990

[Immediate complications in thyroid surgery].

The Authors report the results of a series of 502 thyroid operations (bilateral in 322 cases [64%] and unilateral in 180 cases [36%]), with the aim to evaluate the incidence of early complications and to establish when they were more likely to occur. Preoperative diagnosis was based on scintigraphic scan recently combined to ultrasonography with fine needle biopsy. In all patients a pre and postoperative control of vocal cords motility was performed. Intraoperative identification of recurrent laryngeal nerve was the rule. Complications include a single case of mortality due to cerebral haemorrhage, 2 cases of monolateral recurrent laryngeal nerve paralysis, 4 cases of transient dysphonia, 8 cases of temporary hypoparathyroidism, 5 cases of postoperative bleeding. In three patients a temporary tracheostomy was needed. Thyrotoxic storm did not occur and wound infections were negligible. The various thyroid diseases and their different biological behavior are responsible of the risk factors, local and general ones, which the surgeon must recognize. Diagnostic accuracy, meticulous surgical technique and the best treatment at the first approach are the main factors to prevent complications in thyroid surgery.

Humans↗
PubMed1986

Peripheral blood lymphocyte response to exogenous interleukin 2 by PHA-prestimulated and non-PHA-prestimulated cells in patients with cancer.

The study aims were to assess the response of peripheral blood lymphocytes (PBL) of cancer patients to exogenous Interleukin 2 (IL 2) either by PHA-prestimulated or non PHA-prestimulated PBL, and to carry out preliminary experiments for a direct quantitative evaluation of endogenous IL 2 production by PBL cultures of cancer patients in order to define the actual role of IL 2 in the disease. Analysis of PBL subsets was also carried out with monoclonal antibodies in a selected group of patients. A total of 134 patients entered the study. Cancer sites were: larynx 32, breast 36, lung (NSC) 24, colorectal 17 and gynecologic 25. In the former 3 cancer sites staging showed localized or only locally advanced disease, and in the last 2 sites disseminated disease. Our results provided evidence that cancer patients exhibit a T-cell functional immunodepression, which progresses during tumor growth, so that the localized disease shows a low-grade defect, and advanced disease a high-grade defect. Our data also clearly suggested that the factor involved with a primary role in this functional immune impairment is the IL 2 deficiency. A perspective may be drawn on the therapeutic administration in vivo of IL 2 and IL 2-activated lymphokine-activated killer cells in controlled clinical trials of selected groups of cancer patients.

Cells, Cultured↗
PubMed1985

Persistent TRH-induced growth hormone release after short-term and long-term L-thyroxine replacement therapy in primary congenital hypothyroidism.

No appreciable changes in plasma GH levels after TRH stimulation have been observed in normal subjects, whereas acute GH release has been reported in primary hypothyroidism and other pathophysiological states. To evaluate the effect of the T4 replacement therapy on TRH-induced GH release, 28 patient volunteers with primary congenital hypothyroidism (PCH), were studied before (11 subjects), after 1 month (nine subjects) and after long-term T4 replacement therapy (eight subjects). All patients underwent a TRH test with measurement of TSH, PRL and GH levels, and were compared to 28 age-matched normal subjects. An increase of plasma GH after TRH was found in 46% of patients without any therapy, in 67% of patients after one month of T4 administration and in 75% of patients after long-term therapy. No changes were observed in plasma GH levels in controls. The TSH response to TRH was inhibited and the response of PRL was reduced step by step by T4 replacement therapy in our patients with PCH. Our results suggest that: (i) Replacement T4 therapy in PCH does not abolish the paradoxical GH response to TRH, in spite of inhibiting the TSH response and reducing the exaggerated PRL response; (ii) the GH response to TRH in PCH seems to be unrelated to low thyroid hormone levels and/or to high TSH levels, but it could be due to changes in hypothalamic-pituitary regulation which are not improved by T4 replacement therapy.

Adolescent↗
PubMed1984

[Prognostic value of CEA in postoperative monitoring of colorectal cancers].

The prognostic value of CEA for the purposes of postoperative monitoring assessed in 45 patients with cancer of the colon and rectum. Values were obtained 1-36 months after surgery in all operable cases. Means were also evaluated statistically at various follow-up times. In patients who relapsed, values stayed significantly higher for up to 6 months after surgery than in those who did not. Cockran's method showed that the prognostic significance of this difference 6 months after surgery was p less than 0.05.

Carcinoembryonic Antigen↗
PubMed1980

[Indications and results of thrombo-embolectomy in acute ischemia of the extremities].

A personal series of 176 thrombo-embolisms in the extremities, 157 of them operated, observed at the Surgical Clinic of Cagliari University in the period 1969-1977, is reported. The results of surgery are discussed in relation to the factors which most affect prognosis: age, time and degree of ischaemia, anatomo-pathological condition of the arteries and site of obstruction. Severe ischaemia poses the problem of indication for disobstruction: the possible onset of the revascularization syndrome, which almost always causes the death of the patient, should be borne in mind. Recently proposed local wash-out techniques do not complete solve the problem because although they manage to prevent the revascularization syndrome, they do not always save the extremity, which has to be amputated at a later stage after pointless risks to the patient. On the other hand, the poor functional results obtainable from an extremity that has suffered severe ischaemia must be considered. It is therefore preferred to forgo disobstruction when the ischaemia is so serious that revascularization syndrome is probable.

Adult↗