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Biomedical subjects

G Pizzicannella

Publications and source records attributed to G Pizzicannella.

18 recordsLinked to original sources
PubMed2002

Human dirofilariasis in Italy: a new case in the spermatic cord.

A new case of human dirofilariasis associated with Dirofilaria (Nochtiella) repens (Nematoda, Filarioidea, Onchocercidae) located in the spermatic cord is reported in a 71-year-old man from the province of Campobasso (Central Italy). When clinical signs pointed to a testicular tumor, a monolateral orchifuniculectomy was performed. According to the scientific literature, this case appears to be exceptional in its location, being only the eighth such case recorded in the world until now. The nematode, as well as the presence of vectors suitable for its transmission, had already been observed both in dogs and in humans (3 subcutaneous cases) in the same geographical area.

Aged↗
PubMed2001

[Villograndular adenocarcinoma of uterine cervix: a case report].

We report a case of villoglandular adenocarcinoma of the uterine cervix, discovered in a 69-year-old woman. The patient underwent a radical Wertheim hysterectomy and bilateral pelvic lymphoadenectomy and is alive and well, with no evidence of recurrent disease after 5 years from diagnosis. 13 reports totaling 70 patients with diagnoses of villoglandular adenocarcinoma have been published. The patients ages ranged from 22 to 61 years. Well-differentiated villoglandular adenocarcinoma of the uterine cervix has been recently recognized and described as a distinctive histologic entity which develops in young women. It is possible that cases of villoglandular adenocarcinoma in older women, as our case, were previously considered to represent different histologic types of adenocarcinoma. The differential diagnosis of villoglandular adenocarcinoma is important for prognostic and treatment reasons.

Adenocarcinoma↗
PubMed1996

Omeprazole versus ranitidine: short-term triple-therapy in patients with Helicobacter pylori-positive duodenal ulcers.

AIM: To compare the results of two short triple-therapy regimens, different only in the antisecretory drugs used, in patients with active duodenal ulcer and Helicobacter pylori infection. METHODS: All patients received a combination of clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. for 1 week, in addition to an antisecretory drug: omeprazole 20 mg (50 patients) or ranitidine 300 mg (50 patients) twice daily for 1 week, followed by a single daily dose for a further 3 weeks. Upper gastrointestinal endoscopy, with rapid urease test and histological examination of antral and corpus biopsies, was performed prior to the treatment and at least 2 months after the discontinuation of the antisecretory therapy. RESULTS: Duodenal ulcer healing was documented in all patients at the endoscopic examination after therapy. H. pylori eradication was achieved in 46 of 50 patients (92%, 95% CI = 85-99%) in the omeprazole group and in 43 of 50 patients (86%, 95% CI = 76-96%) in the ranitidine group: the difference is not significant. CONCLUSION: Omeprazole or ranitidine, in combination with clarithromycin and tinidazole, are equally effective in the eradication of H. pylori infection and healing of duodenal ulcers.

Adult↗
PubMed1996

[The role of Enterobius vermicularis in etiopathogenesis of appendicitis].

The authors present 14 cases of enterobiasis of appendix observed between 1991-94, on a total of 1093 appendectomies. The presence of the parasite was associated, in the majority of cases, to a chronic appendicitis. The symptomatology imitates an attack of acute appendicitis, but the true nature of the disease is diagnosed only through a histological examination. There is probably an etiopathogenic relationship between. E. vermicularis and chronic appendicitis, whereas the relationship between the parasite and acute appendicitis is rare and very disputed.

Adolescent↗
PubMed1995

Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas.

Six cases of invasive breast carcinoma with unusual morphological features are reported. The ages of the female patients ranged from 46 to 79 years (mean 60.5). All tumours had areas typical of an adenomyoepithelioma. In three cases adenomyoepithelioma gradually merged with low-grade adenosquamous carcinoma. In the other three patients a sarcomatoid carcinoma was associated with adenomyoepithelial areas. A common origin is proposed for these neoplasms, which extends the morphological spectrum of epi-myoepithelial cell tumours.

Aged↗
PubMed1995

[Peritoneal mesothelioma].

Peritoneal mesothelioma is a quite rare tumor with an incidence of one or two cases per million inhabitants; approximately in the 30-45% of the cases diagnosed it is associated with the corresponding pleural mesothelioma. A predisposing factor is a previous occupational exposure to materials containing asbestos. Clinical symptomatology and instrumental findings may be confusing. Diagnosis is often possible only after direct vision and histologic examination during laparoscopy or laparotomy but it is always tardy, whereas therapy is still unsuccessful. Surgical excision and radiotherapy are less effective than intraperitoneal chemotherapy which seems to lengthen the average survival rate.

Diagnosis, Differential↗
PubMed1995

[Malignant Brenner's tumor of the ovary: description of a case].

A case of malignant Brenner tumor (MBT) in a 42-year-old woman is described. According to the literature it is evident how rare this type of MBT is as well as the histogenetic problems arising in this neoplasia deriving from the coelomic epithelium. The malignant histologic criteria are those adopted in 1973 by Hull and Combell who showed as unquestionable signs the association of benign and malignant Brenner tumor, the invasion of the stroma on behalf of the malignant Brenner elements and the absence of mucinous cystadenoma or the association with the above mentioned.

Abdominal Pain↗
PubMed1993

The epidermal growth factor family in pulmonary carcinoids: immunohistochemical evidence of growth-promoting circuits.

Autocrine neoplastic growth circuits are based on excess synthesis of growth factors and/or cognate membrane receptors. We analyzed by immunohistochemistry 19 typical lung carcinoids for the expression of the epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), EGF receptor (EGFr), and EGFr-related c-erbB-2 protein (p185). Thirteen tumors (68%) were positive for TGF alpha, 11 for EGFr (58%), three for EGF (16%), and four for p185 (21%). Six carcinoids (32%) were consistently negative for these gene products. The following patterns of coexpression could be documented: TGF alpha, EGFr, EGF, and p185: two cases (11%); TGF alpha, EGFr, and EGF: one case (5%); TGF alpha, EGFr, and p185: two cases (11%); TGF alpha and EGFr: six cases (32%); TGF alpha by itself: two cases (11%). Thus, EGFr was coexpressed with its ligands, TGF alpha and EGF, and the receptor encoded by c-erbB-2 was detected in carcinoids positive for EGFr and TGF alpha. Therefore, alterations of EGF/EGFr-related growth control pathways may be implicated in the pathogenesis of pulmonary carcinoids via the establishment of autocrine growth promoting circuits, as documented in adenocarcinomas and squamous cell carcinomas of the lung.

Adenocarcinoma↗
PubMed1990

Sodium cromoglycate in the treatment of eosinophilic gastroenteritis.

Two patients suffering from eosinophilic gastroenteritis (EG) were treated with sodium cromoglycate (SCG). Before treatment they showed enteric and cutaneous symptoms, such as abdominal pain, nausea, vomiting, diarrhoea and recurrent urticaria and angioedema. The histological findings were a notable amount of eosinophilic infiltration in the lamina propria and gastric glands, a villous shortening and thickening and weak eosinophilic inflammation in the duodenum. The patients were treated with 300 mg SCG, 4 times daily, for 4/5 months. During treatment, the clinical symptoms disappeared and at the end of treatment a reduced inflammation with an almost complete decrease of eosinophilic infiltration was observed. The results provide evidence of SCG efficacy in the treatment of EG and suggest its employment as an alternative to the steroids commonly used in EG.

Adult↗
PubMed1987

Dysphagia lusoria: proposal of a new treatment.

Recent observation of one patient suffering from dysphagia lusoria has suggested critical review of treatment of the symptomatic aberrant right subclavian artery. Surgical correction of such an anomaly is difficult and may produce serious complications, and is not always successful. Endoscopic dilatation of the oesophageal stricture, even though it might only produce temporary relief of dysphagia, represents a valid therapeutical alternative because of its favourable cost/benefit ratio, low incidence of complications and patient acceptability.

Aorta, Thoracic↗
PubMedDate not supplied

[Primary lymph node infarct and malignant non Hodgkin's lymphoma. Description of a case].

Primary lymph node infarction and malignant non Hodgkin lymphoma. Case report. We describe a case of spontaneous primary lymph node infarction in a patient who had diagnoseable malignant lymphoma on rebiopsy after a period of 35 days. The first node biopsy showed nearly complete homogeneous necrosis with loss of normal architecture and peripheral rim of organizing granulation tissue. A stain for reticulum, however, showed preservation of the nodal reticulum framework. The follow-up biopsy on the same cervical area, approximately one month later, surprisingly showed a large cell lymphoma. Comparison of reticulum stains of this neoplastic node with earlier stains should dispel any doubts that the first lymph node studied was a true case of non-neoplastic infarction. A review of the literature on lymph node infarction is reported.

Aged↗
PubMedDate not supplied

[Immuno-histopathologic changes in the gastrointestinal mucosa in patients with nickel contact allergy].

The study concerns the histological and immunohistochemical findings of the gastrointestinal mucosa of 20 patients (group A) suffering from contact allergic dermatitis (CAD) to Ni, with symptom recrudescence due to food ingested Ni. Results were compared with those observed in 20 patients suffering from CAD to Ni (group B), without sensitivity to food ingested Ni, and in 20 normal subjects (controls). The sensitivity to food ingested Ni, as suggested by history, was demonstrated by placebo-controlled oral-Ni challenge. The biopsies for histological and immunohistochemical study were performed during endoscopy and obtained from the antrum and from the duodenal mucosa. In the biopsies obtained from 16 of group A patients there was evidence of inflammatory infiltrate of lymphocytes and plasma cells with oedema and vasodilation in the lamina propria. Slight flattening of the villi and enlongation of the crypts were concomitant. These findings were light in the 4 patients of group A and in 11 of group B and instead were absent in the remaining group B patients and in the controls. Immunohistochemically, lymphocytes in the lamina propria were prevalently CD20 + (B cells) and CD4 + (Th cells), some were CD45RO + (memory) and finally few CD8 + (Tc/s cells). CD45RO + cells was found in cluster in patients of group A and in 4 of group B, whereas in the others were isolated. Since some studies have shown that immunological pattern of skin reaction to Ni is characterized by increased CD45RO + cells, it may be hypothesized that in patients suffering from CAD to Ni, the sensitivity to food-ingested Ni may be induced by a type IV immunological reaction in the gut.

Adolescent↗