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G Plank

Publications and source records attributed to G Plank.

20 records · Page 2Linked to original sources

A new real-time mapping system to detect microscopic cardiac excitation patterns.

A new fast, high-resolution measurement system has been developed to analyze the propagation of cardiac excitation on a microscopic scale. The instrument uses a microsensor array to detect microscopic excitation patterns at the cardiac surface. Ninety-six epicardial signals are recorded simultaneously with 14-bit resolution at 200-kHz samples per second per channel. The system operates like a digital oscilloscope. Preprocessing routines (offset, gain, and triggering) are executed within a sampling interval of 5 microseconds by 48 digital signal processors. Analog-to-digital (A/D) converters are provided with 12 Mb of buffer memory, allowing continuous recording of up to 64-k samples x 96 channels. The recorded dataset is transferred rapidly (8 Mb/sec) to the memory of the integrated computer system via VXIbus. Analysis and visualization of the propagating excitation are computed by custom-designed software. The performance of the system allows recording as well as visualization of the cardiac excitation spread in a beat-to-beat manner.

Analog-Digital Conversion↗

In vitro inhibition of adenosine deaminase by flavonoids and related compounds. New insight into the mechanism of action of plant phenolics.

The effects of 20 flavonoids, anthocyanes and other phenolic compounds of plant origin have been tested in vitro for their inhibitory effect on the enzyme adenosine deaminase (ADA). Significant effects were obtained with most compounds at concentrations between 0.0001 and 0.1 mg/mI. Thus, plant phenolics can be considered as natural ADA enzyme inhibitors. It is assumed that they also increase the actual adenosine (Ado) concentration in vivo. This may explain many of the pharmacological activities of these compounds on a molecular basis.

Adenosine↗