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Biomedical subjects

G Pompei

Publications and source records attributed to G Pompei.

At least 19 recordsLinked to original sources
PubMed1996

Type of estrogen receptor determines response to antiestrogen therapy.

Failure of tamoxifen treatment for unresectable hepatocellular carcinomas (HCCs) might be caused by variant estrogen receptors (ERs) in some of these tumors. We therefore planned a study in which antihormonal therapy was done with 80 mg/day tamoxifen or 160 mg/day megestrol according to the presence of wild-type or exon 5-deleted variant ER transcripts. Growth rate (evaluated by MRI) of HCCs characterized by variant ER transcripts was 4 times more rapid than that of HCCs with wild-type ERs. Tumor volume in all patients with wild-type ERs was halved after 9 months of tamoxifen treatment, whereas megestrol in patients with variant ERs only slowed down tumor growth. Choosing antihormonal treatment according to the presence of wild-type or variant ERs in the tumor definitely improves the response rate to tamoxifen; in patients with tumors bearing variant ERs, megestrol causes only a temporary inhibition of tumor growth.

Adult↗
PubMed1988

[Radiologic evaluation of an adverse evolution in total hip prosthesis].

The retrospective study of 50 operated cases of cemented total hip replacement and a review of the literature enabled the authors to define the radiological features of the above-mentioned condition. These features include one or more of the following signs: calcar reabsorption, lacunar erosions, modified relationships between the prosthesis components, sepsis and loosening, periarticular calcifications, dislocation and fracture of prosthesis components. Careful evaluation of these radiological features is extremely important for both an early diagnosis of failed total hip replacement and the choice of an adequate surgical treatment.

Adult↗
PubMed1986

[Fibrinolytic therapy in acute myocardial infarction. Coronarographic evaluation of short-term results].

The authors report their experience in fibrinolytic therapy with Urokinase in acute myocardial infarction. There were 3 groups of treatment: 100 patients with intracoronary fibrinolytic therapy; 77 patients with peripheral venous fibrinolytic administration; 31 patients with conventional therapy. The 3 groups underwent, between 21 and 28 days after the acute event, a coronarographic examination to evaluate the persistence of patency of the vessels involved in the myocardial infarction. The short term results show that the fibrinolytic therapy (with the limitations due to the hemorrhagic complications associated with the use of Urokinase), especially via intracoronary, is significantly more useful and reliable than conventional therapy, which appears unsatisfactory. Therapeutic failures are probably due to diffuse atherosclerosis of the vessel and/or to the old age of the thrombus.

Angiography↗
PubMed1985

[Idiopathic pachydermoperiostitis. Description of a case].

A case of pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy) is presented. This chronic and usually self-limited condition must be differentiated from other diseases, such as acromegaly, the osteoarthropaties complicating disorders of the connective tissue and osteoarthropaties in paraneoplastic syndromes.

Bone Diseases↗
PubMed1985

[Computerized tomography and scintigraphy in the evaluation of osteoid osteoma].

The authors report their experience of bone scintigraphy and computed tomography in 19 patients, with suspected osteoid osteomas, who underwent surgery. Basing on surgical findings, the role of these techniques in diagnosis, surgical planning and follow-up of osteoid osteoma is stressed and the results are compared with those of conventional radiography.

Bone Neoplasms↗
PubMed1982

[Pierre-Marie's osteoarthropathy: scintigraphic diagnosis during staging of lung cancer].

In the last years, total bone scan has gained an important place in the staging of the neoplasms of the lung. Out of 271 patients with lung cancer who underwent a bone scan in the period october 1979-october 1980. 10 showed an increased fixation of the isotope with a linear pattern along the diaphysis of the limbs. These findings, clinically silent, suggested the diagnosis of hypertrophic osteoarthropathy, which has been subsequently confirmed radiologically. The different pathogenetic theories and the evolution of the scintigraphic picture after therapy of the primary disease are briefly discussed.

Adenocarcinoma↗
PubMed1981

[Nelson's syndrome. A case report (author's transl)].

Two cases of Nelson syndrome with typical clinical and laboratory features are presented. Both had radiological evidence of pituitary tumor; in one case it was evident on the plain film while in the other one it was better appreciated by means of tomography. It is important in the post-surgery follow-up of patients who underwent bilateral adrenectomy for Cushing's disease a periodical evaluation of skin pigmentation, visual field width and sellar morphology for the early detection of a pituitary adenoma.

Adolescent↗
PubMed1979

[Thoracic outlet syndromes. Arteriographic aspects].

Chest outlet syndromes are characterized by pain symptomatology caused by (congenital or acquired reasons) compression of the vasculo-nervous bundle. After a brief mention of the anatomy of the question, the indications and angiographic technique are reported, special reference being made to certain positions and dynamic tests which increase symptomatology and highlight arteriographic findings. These are clearly identifiable in the pictures and offer documentary evidence of the cervical rib syndrome, scalenus syndrome, small pectoral syndrome, the hyperabduction syndrome and the costoclavicular syndrome. Differential diagnosis should consider a number of painful syndromes of the upper extremity of purely neurological interest (involvement of the brachial plexus). Vascular diseases such as arteriosclerosis, Takayasu's disease, etc., osteo-myo-articular and ORL sector diseases should also be taken into account. Arteriography is able to identify with precision the causes of the clinical syndrome and to guide surgical exploration of the supraclavicular fossa with excellent chances of success.

Aortography↗
PubMed1975

[Value and limitations of intravenous cholangiography in the diagnosis of the main bile duct diseases. Studies in 209 cases controlled surgically].

The value and limits of i.v. cholangiography were appraised in the light of the surgical picture in 209 patients. Exact preoperative diagnosis was possible in many cases, while no more than dilatation of the main bile duct was demonstrable in others. False negatives mainly concerned lithiasis of the common duct without jaundice, whereas false positive lithiasis was primarily observed in papilitis and cephalopancreatitis.

Adolescent↗