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Biomedical subjects

G Prónay

Publications and source records attributed to G Prónay.

15 recordsLinked to original sources
PubMed1985

Screening for colorectal cancer in a Hungarian county.

An initial screening for colorectal cancer in asymptomatic adults was performed with Haemoccult in 26,357 persons, rigid rectoscopy in 10,673 and flexible sigmoidoscopy in 3,963 persons. The rate of cancer detection was 4.4% in screenees with a positive Haemoccult test, 0.08% using rigid rectoscopy and 0.28% using flexible sigmoidoscopy. The respective frequency of patients discovered to have polyps was 16.2%, 1.32% and 8.49%. 77% of the 36 colorectal cancers detected due to the Haemoccult test program were either Dukes A or B. A comparison of these screening results indicates that Haemoccult screening markedly increases the yield of colorectal neoplasms when asymptomatic persons are examined. This screening should be repeated annually to reduce the morbidity and mortality of colorectal cancer.

Adenoma↗
PubMed1985

Therapeutical experiments in ulcerative colitis and Crohn's disease.

In the period 1963-82 among the patients with aspecific inflammatory bowel disease, the incidence of ulcerative colitis was 3.1 per 100 000 per year, while the frequency of Crohn's disease has doubled during the observation period and now its incidence is 0.58 per 100 000 per year. During the past 20 years, 404 patients with ulcerative colitis were treated. The average follow-up of the patients lasted for 6.6 years. During this period, 40% of the patients could be kept in balance permanently with salicylazosulfapyridine (SASP) monotherapy. A further 34% reacted to SASP plus steroid. The rate of regression was increased by a further 14% when the combination was occasionally completed with a short-term antibiotic or prolonged azathioprine therapy. The inestimable cases and those refractory to treatment made up the other 12% and among them are also the 23 colectomized patients. During the two decades 40 patients with Crohn type ileocolitis were treated. SASP administration by itself was sufficient in only one case among them. In 6 cases steroid, in 4 antibiotics, in 7 azathioprine and in 2 cases metronidazole treatment had to be introduced complementarily. The fact that 21 of the 40 patients had to be subjected to bowel resection in some phase of the disease, shows how impossible it is to evaluate the different therapeutic interventions.

Azathioprine↗
PubMed1983

Carcinoid tumours of the rectum.

Carcinoid tumours of the rectum occur relatively seldom. The personal experience was 11/20,0000 rectoscopies. The symptoms are not characteristic. Such tumours can mostly be detected by chance. The basic diagnosis can only be achieved through thorough histological examinations. The tumours are usually not larger than 1 1/2 cm in diameter. Usually are restricted to the mucosa and submucosa, are solitary and can be treated perfectly with endoscopic excision. In case the tumour either invades the muscular layer, reaches or exceeds the diameter of 2 cm, or occurs in a multiple form a radical surgical approache is needed, resection should be performed.

Adult↗
PubMed1982

Colitis carcinoma in ulcerative colitis.

During the period from 1963 till 1981 altogether 342 patients suffering from ulcerative colitis were treated. In their material authors found 6 patients (1.7%) who achieved cancer of the colon beginning 7, 9, 14, 18, 18 und 21 years after the onset of ulcerative colitis symptoms. According to the clinical data their ulcerative colitis could be considered to belong to the severe or the moderate type. From the anatomical point of view the extension of the process exceeded the sigmoid colon in all but one. Respecting the clinical course of the disease, malignant transformation took place in 3 patients of the relapsing-remitting type, in 2 instances the clinical course could not be classified, the sixth case proved to the chronic continuous type. Colonic tissue was gained and diagnosis stated with traditional methods within 4 instances, while in 2 it was gained from tissue specimens passing through the stool. In 3 cases the tumour was multiple. From the morphological point of view the features had a plaque form in 2 cases, a polypous nature in other 2 cases, while among each one patient a fibrous stricture and ordinary colorectal cancer occurred. The tumour was identified as well differentiated and poorly differentiated adenocarcinoma in identically 3 instances. All the patients underwent an operation, only one of them is still alive. In sake of detecting colitis carcinoma earlier, they suggest yearly endoscopic and biopsy survey of ulcerative colitis patients.

Adult↗