PubMed Health⌕ Search

Biomedical subjects

G Probst

Publications and source records attributed to G Probst.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Technique and results of surgery for lung metastasis].

Surgical treatment of pulmonary metastases is part of an interdisciplinary strategy in oncological therapy. Between 1973 and 1989, 620 thoracotomies were performed in 549 patients. The most profitable access was the median sternotomy. Thirty-day mortality was 2.7%, 5-year survival was 30% for all patients. If the resection was classified as potentially curative, 5-year survival was 35%. Patients with pulmonary metastases of testicular tumors (5-year-survival rate 70%) had the best prognosis. Prognostic factors must take the primary tumor into consideration.

Follow-Up Studies↗
PubMed1990

[Results of surgical treatment of lung metastases].

Surgical removal of one or several metastases with a potentially curative aim is possible in the case of isolated pulmonary metastases. Surgery is part of a combined oncological concept. Between 1972 and 1986 surgical resection was indicated in 368 patients and 419 thoracotomies were carried out. 38% of the patients showed more uni- or bilateral metastases than expected after the most careful preoperative diagnostic examinations. The 5-year survival probability of all operated patients was 33%. Corresponding to a differentiation between potentially curative and non-curative resections the operation was classified as potentially curative in 73% of the cases. In this group the 5-year survival rate amounted to 39%. Differentiation into tumor (carcinomas of caval type, carcinomas of portal type and sarcomas) revealed no statistically significant differences of prognosis. Thanks to the excellent chemotherapeutical regimens, testicular teratomas showed the best results in the first postoperative years. Long-term survival is decisively influenced by the removal of all visible and palpable metastases. If complete removal of all tumor tissue is possible the number of metastases do not influence survival significantly. Besides radicality the duration of the disease-free interval showed prognostic differences which were statistically provable (p less than 0.0001). Depending on the metastatic route and primary tumor type there were slight prognostic differences which were not statistically significant. Within the last years median sternotomy became the preferred access. The main resection procedures are wedge and segmental resections which yield the best survival rates.

Adolescent↗
PubMed1989

[Results and complications of treatment of acute and chronic pleural empyema--a retrospective analysis of the last 5 years].

In 162 patients treated surgically for pleural empyema, 212 surgical interventions were necessary. As primary treatment cest-tube drainage was more effective than closed chest tubes. Decortication, which was carried out in 43 patients, was followed by further surgical procedures in three patients. If primary treatment is not effective early decortication is indicated to avoid septic complications (30-day mortality amounted to 7.4%). Two patients died from septic complications.

Chronic Disease↗
PubMed1988

Results of surgical treatment of pulmonary metastases.

Surgical removal of one or several metastases with a potentially curative aim is possible in the case of isolated pulmonary metastases. Surgery is part of a combined oncological concept. Between 1972 and 1986, surgical resection was indicated in 368 patients and 419 thoracotomies were carried out. Of the patients, 38% had more uni- or bilateral metastases than expected even after the most careful preoperative diagnostic examinations. The 5-year survival probability of all patients operated on was 33%. Corresponding to a differentiation between potentially curative and non-curative resections, the operation was classified as potentially curative in 73%. In this group, the 5-year survival was 39%. Differentiation into tumour groups (carcinomas of caval type, carcinomas of portal type and sarcomas) revealed no statistically significant differences in prognosis. Due to the excellent chemotherapeutical regimens, testicular teratomas achieved the best results in the early postoperative years. Long-term survival is decisively influenced by the removal of all visible and palpable metastases. If complete removal of all tumour tissue is possible, the number of metastases does not influence survival significantly. Besides radicality, the duration of the disease-free interval showed prognostic differences which were statistically significant (P less than 0.001). Considering the metastatic route and the type of primary tumour, there were slight prognostic differences which were not statistically significant. Recently, the median sternotomy has become the preferred method of access. Predominating resection procedures are wedge and segmental resections which yield the best survival rates.

Adolescent↗
PubMed1988

Histomorphological aspects of TNM-classification of carcinoma of the lung.

This prospective study evaluates the histopathological findings on 613 patients undergoing curative resection of a bronchus carcinoma and operated on between January 1982 and September 1984. The WHO rules for tumor classification and grading, and the 1979 pTN classification rules of the UICC were followed. Taking into account the biological properties of the tumors and the patient survival times, the prognostic value of histopathological data is discussed. Apart from the clear general dependence of the average survival time on the tumor cell type, it was found that tumor volume is of greater prognostic value with respect to patient survival than tumor diameter.

Adenocarcinoma↗
PubMed1988

[Evaluation of intrapulmonary round foci using thin-layer computed tomography].

100 patients with 122 round pulmonary lesions were examined preoperatively by CT, using either 8 mm or 2 mm sections. The most important findings were: radial extensions were seen on the fine sections in 95% of primary bronchial carcinomas (48 cases), in 60% of lung metastases (31 cases) and in 70% of chronic inflammatory lesions (24 cases), but they were not seen in benign tumours or hamartomas. Similar findings were observed for perifocal consolidation. Calcification was found in 80% of the tuberculomas (15 cases) and in 37% of the hamartomas (8 cases), but it also occurred in 15% of the primary bronchial carcinomas and in almost 13% of the lung metastases. Thin section CT provided more information than did 8 mm sections in 44% patients, concerning the outline of the lesion, and in 60% it was better at showing calcification. It was not possible to define a pattern of calcification which would distinguish benign from malignant lesions.

Adult↗
PubMed1988

[Synopsis of computed tomography, scintigraphy and bronchoscopy in the diagnosis of bronchial carcinoma].

In 87 patients with histologically proven bronchogenic carcinoma, computerised tomography (CT) and bronchoscopy were performed to assess the accuracy of CT in detecting bronchial stenosis. Whereas patent airways and mainstem stenosis were recognised in 85% of the cases, the overall accuracy was only 57%. Furthermore, the results of both methods were compared to scintigraphy (ventilation, perfusion) to evaluate the functional impairment due to altered lung morphology and bronchial stenosis. With an increasing number of CT-diagnosed atelectatic or infiltrated segments an almost linear decrease in ventilation and perfusion values was observed. In comparison, bronchoscopy-diagnosed tumour stenosis resulted in decreased ventilation and perfusion data only if the lesion was centrally located.

Adenocarcinoma↗
PubMed1988

[The value of computed tomography in the search for an unknown primary tumor].

CT scans of 31 patients, who had been evaluated because of metastases of unknown origin, were reviewed. Diagnosis of the primary site was established in 18 of the 31 patients only. More than 18 patients had metastatic adenocarcinomas. CT scans were helpful in identifying an occult primary tumour in 6 patients; in 5 cases the primary location could not be detected by CT examination. In 2 patients CT scans considered a wrong organ to be the site of an unknown primary tumour.

Adenocarcinoma↗
PubMed1988

[Computed tomographic findings in 36 patients with space-occupying lesions of the thymus].

The CT examination of 36 patients with masses in the thymus (three thymus hyperplasias, 33 thymomas) were evaluated retrospectively. Three tumours in atypical positions posed problems in differential diagnosis from bronchial carcinomas and two cases with extensive pleural metastases had to be differentiated from pleural mesotheliomas. There were no certain morphological features on CT which indicated whether the mass was malignant. Eleven patients with thymomas had metastases; in seven of these they were extra-thoracic, with preference for supraclavicular lymph nodes, adrenals and the axial skeleton. Tumour progression and distant metastases were found particularly in malignant thymomas of the epithelial type. Calcification in a thymoma tends to indicate that it is malignant.

Adolescent↗
PubMed1988

[Surgical therapy of bronchial cancer].

Over the last decades the medical and social importance of bronchial carcinoma has increased because of its incidence and poor prognosis. Until recently only surgery has offered the chance of a cure for non-small-cell lung cancer with a 5-year-survival of 25%. Today with the development of tissue-sparing techniques curative treatment is accessible also to patients with limited lung function and centrally located tumors.

Adult↗
PubMed1987

Retrospective and prospective tumor staging evaluating prognostic factors in operated bronchus carcinoma patients.

Survival, pTN stages, and cell type of patients operated on for bronchus carcinoma were evaluated in a retrospective study and compared with data obtained in a prospective study. One thousand three hundred thirty-two patients with potential curative resected lung carcinoma were included in the retrospective study. Two hundred eighty-two patients with potential curative resected lung carcinoma were analyzed in the prospective study. Data showed similarities in distribution of cell type and relative frequency of pT1 stage in both collectives. Major differences between both studies were obtained in relative frequencies of pT3, and pN0, pN1, and pN2 stages. Survival of patients grouped according to cell type revealed differences between patients suffering from epidermoid-adeno carcinoma and patients suffering from small anaplastic carcinoma--large cell anaplastic carcinoma in both studies. Patients stated as pN0 stages showed more favourable prognosis in the prospective study compared with patients of the retrospective study. Two-year survival rates of patients grouped into a pT1pN0 stage and into a pT2pN0 stage had similar survival rates in both studies. Survival of these cohorts compared with patients staged as pT1pN1 and pT2pN1 was statistically significantly better. The data indicate that patients suffering from pT1pN1 or pT2pN1 tumors should be classified as Stage II tumors.

Age Factors↗
PubMed1987

A protocol and guide for the in vitro rat hepatocyte DNA-repair assay.

The in vitro rat-hepatocyte DNA-repair assay is a valuable tool in assessing the genotoxic activity of chemical agents. An advantage of the assay is that the target cells themselves are metabolically competent, so that the patterns of metabolic activation and detoxification closely reflect those in the whole animal. This article provides a typical procedure and guidelines for conducting the rat in vitro hepatocyte DNA-repair assay.

Animals↗
PubMed1987

A protocol and guide for the in vivo rat hepatocyte DNA-repair assay.

The in vivo rat hepatocyte DNA-repair assay is a valuable tool in assessing the genotoxic activity of chemical agents. An advantage of the system is that it reflects the complex patterns of uptake, distribution, metabolism, detoxification and excretion that actually occur in the whole animal. This article provides a typical procedure and guidelines for conducting the rat in vivo hepatocyte DNA-repair assay.

Animals↗
PubMed1986

Open clinical study with suprofen drops in the treatment of postoperative and posttraumatic pain.

Analgesic effect and tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) drops were tested in an open study including 51 informed outpatients with moderate to severe postoperative and posttraumatic pain. Suprofen drops were administered for 7 days, at doses of 33 drops (= 200 mg of suprofen) t.i.d. or q.i.d. The pain intensity was recorded prior to the treatment and after 2, 4 and 7 days; pain relief was assessed on days 2, 4 and 7. Effectiveness and tolerability were by the investigator and by the patients globally evaluated upon completion of the trial. The intensity of pain dropped within the 7-day treatment period from initially severe pain to mild. Pain relief was seen in 92% of the subjects after day 2, in 98% after day 4, and in 100% after day 7 of treatment. Investigator's and patients' final evaluation of the therapeutic effect indicated good analgesic activity in 86% of the population, and very good analgesic effect in 84%. Moderate effect was seen in 12 and 14%, respectively. The tolerability of suprofen drops was by investigator and patients considered good to very good in 82% of the cases, moderate in 16%, and poor in 1 case.

Adult↗