Biomedical subjects

G Puviani

Publications and source records attributed to G Puviani.

15 recordsLinked to original sources

PubMed1989

Left ventricular performance in the natural history and after corrective surgery of isolated ventricular septal defect.

Left ventricular performance by determination of the systolic time intervals, was analyzed in 34 patients with isolated ventricular septal defect and unidirectional left-to-right shunt. Fourteen of them (group I) with mean pulmonary flow/systemic flow ratio 2.19 +/- 0.3 SD, underwent corrective surgery; the other 20 patients (group II) with mean pulmonary flow/systemic flow ratio 1.43 +/- 0.3 SD were not operated; all the patients were followed up for at least 10 years. The measurements were obtained from simultaneous high speed photographic recordings of electrocardiogram, external carotid pulse and phonocardiogram. The analysis of data in group I showed a significant prolongation of pre-ejection period and an abbreviation of left ventricular ejection time; the degree of abbreviation was related to the magnitude of the shunt. The above abnormalities persisted after corrective surgery, and only several years after the operation these parameters became normal. Instead, the systolic time intervals were always normal in group II during the whole follow-up period. The most likely explanation for the observed abnormalities in ventricular septal defect in group I is that the depressed contractility of the left ventricle, which is secondary to the important volume overload, persists after corrective surgery. Septal construction abnormalities, before and after ventricular septal defect repair, may be another contributing factor in abnormal systolic time intervals.

Adolescent↗

PubMed1986

Systolic time intervals in patent ductus arteriosus before and after corrective surgery.

Systolic time intervals (STI) were analyzed in 11 patients with isolated patent ductus arteriosus (PDA) and unidirectional left-to-right shunt, before, shortly after (within 2 months) and a long time (at least 10 years) after the corrective surgery. The measurements were obtained from simultaneous high speed photographic recordings of electrocardiogram, external carotid pulse and phonocardiogram. Before the operation, the left ventricular ejection time (LVET) was significantly prolonged (p less than 0.01) and this abnormality was correlated with Qp/Qs (r = 0.74, p less than 0.01). Shortly after the operation, the LVET was shorter than normal, and became normal only a long time after. It is concluded that the most likely explanation for these abnormalities is: 1) before the operation, the increased stroke volume of the left ventricle secondary to the shunt, and 2) after corrective surgery, the depressed contractility of the left ventricle secondary to the long-standing volume overload which tends to persist after the corrective surgery.

Adolescent↗

PubMed1984

Systolic time intervals in isolated septal defects before and after corrective surgery in female patients. I. Atrial septal defect.

Systolic time intervals (STI) were evaluated in 19 female patients with uncomplicated ostium secundum atrial septal defect (ASD), before, shortly after (within 2 months) and a long time after the corrective surgery (mean 13.2 years). The measurements were obtained from simultaneous high speed photographic recordings of electrocardiogram, external carotid pulse and phonocardiogram. Before the operation, a significant prolongation of Q-I heart sound interval was detected, together with a less prominent but statistically significant shortening of the left ventricular ejection time; the above alterations were not correlated with the magnitude of the shunt and disappeared shortly after corrective surgery. The STI were still normal a long time after surgical closure of ASD. In accordance with hemodynamic studies reported by other authors, our results confirm that the deviations of STI observed in ASD are due to a reduced diastolic filling of the left ventricle secondary to an apparent decreased distensibility.

Adolescent↗

PubMed1984

Systolic time intervals in isolated septal defects before and after corrective surgery. II. Ventricular septal defect.

Systolic time intervals (STI) were analyzed in 34 patients with isolated ventricular septal defect (VSD) and undirectional left-to-right shunt. 14 of the patients who underwent corrective surgery were followed-up for at least 10 years. The measurements were obtained from simultaneous high speed photographic recordings of electrocardiogram, external carotid pulse and phonocardiogram. Before the operation the Q-I sound interval and, consequently, the pre-ejection period were significantly prolonged and the left ventricular ejection time significantly abbreviated, the degree of abbreviation relating with the magnitude of the shunt. The above deviations persisted after corrective surgery, and only several years after the operation the parameters studied became normal. It is concluded that the most likely explanation for these abnormalities is the depressed contractility of the left ventricle, secondary to the long-standing volume overload, which tends to persist after corrective surgery.

Adolescent↗

PubMed1983