Biomedical subjects

G Q Fu

Publications and source records attributed to G Q Fu.

4 recordsLinked to original sources

PubMed2001

[Apoptosis during placentation].

Apoptosis is a normal physiological phenomenon. During the process of implantation, there are a large number of cells at the implantation site undergoing apoptosis, which has been suggested to play an important role in the regulation of endometrium decidulization and trophoblast invasion. Apoptosis mediated by Fas/FasL system may also be associated with maternal immunotolerance to the fetus. In this review, the common pathway of apoptosis and the regulation in the placenta are described.

Apoptosis↗

PubMed1999

Cloning of novel temperature-related expressed sequence tags in rat testis during spermatogenesis.

Spermatogenesis needs the relatively cool environment of the scrotum in most mammals, it would be arrested when the testis was exposed to abdominal temperature. In this study, we have used a differential display PCR technique (DD-PCR) to screen temperature-related ESTs during spermatogenesis (TRS) in scrotal testes through a unilateral cryptorchid rat model after in situ analysis of testis cell DNA fragmentation. We reported here the cloning and sequencing of three such ESTs: TRS1, TRS3, and TRS4. Northern blot analysis confirmed that they were expressed specifically in scrotal testes. In situ hybridization showed that TRS1 was mainly expressed in the spermatocytes and the round spermatids in scrotal testis. Homology searches revealed that TRS1 and TRS3 were unknown cDNA sequences, and TRS4 was identical to a known EST whose function had not been reported. TRS1, TRS2, and TRS3 were first found to be temperature-related during spermatogenesis.

Animals↗

PubMed1990

[Experimental study on effect of lipid-lowering and treating coronary atherosclerosis with Chinese herbal prescription].

The Chinese herbal prescription was used in lipid-lowering, preventing and treating coronary atherosclerosis in this experiment. Through over 200 Leghorn chickens mould experiment and pathological sections were observed. The authors found that the effective rate of cholesterol-lowering was 88.23%, P less than 0.01. The authors also took 52 chickens with coronary atherosclerosis for medical treatment, after 40 days, 65.38% of chicken's artery pathological changes went down from higher than degree II to lower than degree II and 4 chickens' artery wall became normal. Before collagen pathologic changes occurred, fatty deposits on artery wall were changeable. After effective treatment it can take a turn for the better.

Animals↗

PubMedDate not supplied

Hormonal regulation of plasminogen activator in rat and mouse seminiferous epithelium.

To elucidate the possible role of plasminogen activator (PA) in spermatogenesis and spermiation in mammals, we studied the hormonal regulation of PA secretion in cultured rat and mouse seminiferous tubules during defined stages of spermatogenesis. Results indicated that: (1) under basal conditions, segments of rat seminiferous tubules released primarily urokinase-type PA (uPA) at all stages of the cycle. The highest level of PA secretion occurred at stages VIIab, VIIcd and VIII. FSH, 8-bromo cyclic AMP and forskolin (FK) stimulated PA secretion, predominantly tissue-type PA (tPA). (2) In contrast, mouse seminiferous tubules secreted only tPA under basal conditions. In the presence of 50 microM MIX, seminiferous tubules at stages VII and VIII secreted higher levels of both types of PA than at the other stages. Both tPA and uPA secretion was enhanced by addition of FSH and FK to the organ culture media. (3) Segments of both rat and mouse seminiferous tubules at stages IX-XII in which the sperm residual bodies are absorbed into the Sertoli cells were also very sensitive to the addition of FSH to the organ culture. These results suggest that tPA in rat and mouse testes may play an essential role in the process of spermatogenesis and spermiation as well as in sperm residual body absorption.

1-Methyl-3-isobutylxanthine↗