Biomedical subjects
Publications and source records attributed to G Qin.
Three new bibenzyls were isolated from the roots of Stemona tuberosa. Their structures were identified by spectroscopic methods as 3,5-dihydroxy-4-methylbibenzyl, 3,5-dihydroxy-2'-methoxy-4-methylbibenzyl and 3-hydroxy-2',5-dimethoxy-2-methylbibenzyl.
From the roots of Clematis chinensis, two new triterpenoid saponins, named clematichinenoside A and B, were isolated and their structures were elucidated as 3-O-beta-D-ribopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-2)-alpha -L- arabinopyranosyl oleanolic acid 28-O-beta-D-glucopyranosyl ester and 3-O-beta-D-glucopyranosyl-(1-4)-beta-D-ribopyranosyl-(1-3)-alpha-L - rhamnopyranosyl-(1-2)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl-(1-4)-beta-D-glucopyranosyl-(1-6)- beta-D-glucopyranosyl ester, respectively. In addition oleanolic acid, hederagenin and seven known saponins were obtained.
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Three new triterpenoidal saponins, mussaendosides O [1], P [2], and Q [3] were isolated from whole plants of Mussaenda pubescens. These structures were elucidated on the basis of chemical and spectral methods, such as their 1H-1H COSY, HMQC, HMBC, TOCSY, and NOESY nmr spectra.
Seventy piglets with no access to creep feed were weaned at 28 d of age and fed on one of four diets based on either skimmed-milk powder (SMP), soya-bean-protein concentrate (SPC), soya-bean meal (SBM) or fish meal (FM). At 0, 3, 6 and 10 d after weaning, piglets were killed and the pancreas and digesta from stomach and small intestine were collected, freeze-dried and analysed for dry matter (DM), N, and trypsin (EC 3.4.21.4) and chymotrypsin (EC 3.4.21.1) activities. Small-intestinal tissue samples were taken to examine gut wall morphology. Results indicated that dietary protein source affected post-weaning feed intake, pancreatic weight, gastric pH and gastric protein breakdown, and pancreatic and jejunal trypsin and chymotrypsin activities. Post-weaning feed intake appeared to be an important factor in digestive development of newly-weaned piglets.
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We systematically studied the effect of 50% casein diet on iodide goiter by surveying the changes of thyroid weight, thyroid iodine content, thyroid histology, thyroid peroxidase activity, serum thyroid hormones and TSH concentration in mice fed with excessiodine water. The results showed that 50% casein diet could significantly inhibit iodide goiter. The probable mechanism could be related to the casein which reduces the excess iodine entrance into the thyroid cells and decreases the excess colloid formation in the follicular lumen.
The developmental switch from production of fetal (gamma) to adult (beta) globin occurs on a normally set biologic clock which proceeds even if the adult (beta) globin genes are defective. Preventing or reversing the globin gene switch would be beneficial for subjects with abnormal beta globin genes. We have now identified a class of agents which, when present in elevated plasma concentrations during gestation, appears to inhibit the gamma beta globin gene switch in developing humans. Further investigation has shown that butyric acid and related compounds can increase gamma globin and decrease beta globin expression in erythroid cells cultured from subjects with diseases of abnormal beta globin. Butyrate compounds were therefore infused in an in vivo fetal animal model, and the globin switch was inhibited in most and reversed in some fetal lambs. These data suggest that inhibiting expression of abnormal beta globin genes may be possible in future generations. Histone modification may be a mechanism of action involved. The developmental switch from production of gamma globin to beta globin results in significant morbidity when the beta globin genes are defective. The globin switch has therefore been extensively studied, appearing to be set on a biologic clock and proceeding despite the site of blood production and solely on the basis of gestational age. We previously found that this developmental gene switch is delayed in human fetuses developing in the presence of maternal diabetes. A number of metabolites present in abnormal concentrations in these infants were therefore tested for effects on globin expression.(ABSTRACT TRUNCATED AT 250 WORDS)
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