PubMed Health⌕ Search

Biomedical subjects

G R Cumming

Publications and source records attributed to G R Cumming.

84 records · Page 5Linked to original sources
PubMedDate not supplied

Cardiac stroke volume: effects of athletic training.

A high capacity oxygen transport system requires a large cardiac stroke volume. This may be achieved by an increase in the systolic emptying of the heart as might occur with training programs of one to three months. Any major increase in stroke volume must be achieved by an increase in the diastolic heart volume. Only the athlete with an extraordinary degree of endurance fitness develops this change and it likely requires at least a few years of training. Some of this training may have to take place during puberty and rapid growth years. To some extent the capacity to increase stroke volume may be genetically determined. We have no information on the best way to train the heart to have a high stroke volume. The inadequate data available suggest that moderately intense interval work with supine recovery periods results in the largest possible stroke volume, but it is not known whether this is of any practical value for training athletes.

Adolescent↗
PubMedDate not supplied

Pulmonary hypertension in a child with mixed connective tissue disease.

Mixed connective tissue disease (MCTD) is characterized by high titers of antibody to ribonucleoprotein (RNP) in patients with features of several rheumatic diseases. We describe a child whose MCTD included arthritis, Raynaud's phenomenon, mucocutaneous ulcerations, sclerodermatous skin changes, restrictive lung disease, reduced carbon monoxide pulmonary diffusing capacity, abnormal esophogeal motility, and severe pulmonary hypertension. High antibody titers to ds-DNA and RNP were present. Clinical improvement followed therapy with prednisone and cyclophosphamide. Improvement in the degree of pulmonary hypertension was documented by repeat cardiac catheterization 8 months after the initiation of combination therapy.

Adolescent↗