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Biomedical subjects

G R Doran

Publications and source records attributed to G R Doran.

7 recordsLinked to original sources
PubMed1985

Hyperbaric liver dysfunction in saturation divers.

Earlier demonstration of elevated blood thyroid hormones and transaminase activities during controlled chamber dives to 540 and 660 msw [at AMTE(PL), Gosport, England; 1980 and 1981] led to the suspicion that high compression may interfere with liver function. Further studies, here described, of blood thyroid hormone level changes during the course of subsequent dives indicate that thyroxine and reverse triiodothyronine elevations are to be expected during any period of sustained compression, to depths as shallow as 61 msw. Moreover, blood levels of thyroxine-binding globulin (TBG), measured in the 540 and 660 msw dives, were also shown to rise, probably accounting for the hormone changes. This elevation is not confined to TBG, being demonstrable in at least six other glycoproteins (sex hormone-binding globulin, transferrin, ceruloplasmin, haptoglobin, alpha 1 acid glycoprotein, and alpha 2 macroglobulin). Since all these proteins share identical or very similar metabolic fates within the liver, these findings lend further weight to our hyperbaric liver dysfunction theory. How such disturbances may come about is discussed, together with its possible implications apropos high pressure nervous syndrome and divers' well-being and capabilities while at depth.

Diving↗
PubMed1979

Appearance of creatine kinase BB isoenzyme in the serum of a patient suffering from infarction of the colon.

A case is described of multiple pathologies which was associated with very high levels of total serum creatine kinase activity. Electrophoretic analysis showed the circulating enzyme to be made up of all three isoenzyme fractions; MM, MB and BB. Acute necrosis of a portion of large intestine seems the most likely explanation for the transient appearance of the BB fraction. The implications of these findings with regard to creatine kinase isoenzyme analysis techniques are discussed.

Adult↗
PubMed1975

The origin of the elevated activities of creatine kinase and other enzymes in the sera of patients with myxoedema.

An attempt has been made to establish the origin of the elevated serum creatine kinase which occurs in most patients with myxoedema. Parallel determinations of a number of other serum enzymes were made but the incidence of elevated values was appreciably less than in the case of creatine kinase. Rather surprisingly, the serum amylase activity was found to be increased in more than 50% of the patients studied. Creatine kinase isoenzymes were separated by starch-gel electrophoresis of the sera of 26 patients with myxoedema. In 25 the MM isoenzyme only could be identified while the remaining serum also contained a trace of the MB fraction. Similar isoenzyme studies were made with the sera of normal and thyroidectomized rats, all of which are shown to contain all three isoenzymes. (MM, MB and BB) irrespective of thyroid functional status. No consistent difference was apparent between the patterns exhibited by the thyroidectomized and control groups, and it was concluded that thyroidectomized rats cannot be regarded as a suitable experimental model for the study of this aspect of human hypothyroidism. It is suggested that enzyme release in myxoedema is a non-specific effect, possibly die to diminution in the ATP content of tissues generally. The greater incidence of creatine kinase elevation is probably due to the relatively high concentrations of this enzyme in skeletal muscle, the mass of which is much greater than that of any other tissue.

Adenylate Kinase↗