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Biomedical subjects

G R Gazizova

Publications and source records attributed to G R Gazizova.

10 recordsLinked to original sources
PubMed1986

[Electron microscopic study of the cytopathogenic action of meningococci in a continuous human amnion cell culture].

The electron-microscopic study of the interaction of meningococci with continuous human amnion cell culture F1 has revealed that this process comprises 3 stages. The study has shown that, following the adhesion of meningococci to the surface of cells F1, these cells are invaded by individual coccal forms of meningococci. In response to infection vacuoles appear in the cytoplasm of the cells. Meningococci are either phagocytosed inside these vacuoles, or their release into the intercellular space and the death of the infected by meningococci are observed. When the cells are infected by cytopathogenic strains, the infectious process results in the appearance of degenerative changes in the cells.

Amnion↗
PubMed1985

[Interactions between Neisseria meningitidis and cell cultures (data of cytomorphologic studies)].

The present work shows that the cytopathogenic action of N. meningitidis on continuous human amniotic epithelial cell culture FL begins from their active adhesion and subsequent invasion. The degree of the manifestation of the cytopathic effect depends on the capacity of the infective agent for adhesion and invasion and on its biological properties, as well as on the initial state of the cells. The infection of the cells is accompanied by disturbances in their mitotic activity together with the lesions of their chromosomal apparatus. The cells die either in the state of degenerative mitosis, or as the result of the rupture of the cytoplasm in massively invaded cells. The response of the cells to the invasion of faintly cytopathogenic and noncytopathogenic strains takes the form of nonprofessional phagocytosis.

Adhesiveness↗
PubMed1984

[Characteristics of nonpathogenic Neisseria and Branhamella catarrhalis based on cytopathogenicity].

The study of the action of 12 Neisseria species belonging to 112 strains, 6 B. catarrhalis strains and 202 meningococcal strains on the culture of continuous cell line F1 (human amniotic cells) has revealed that nonpathogenic Neisseria are essentially weaker than meningococci in their pathogenicity (expressed in terms of CPD50). Among nonpathogenic Neisseria highly cytopathogenic strains occur in 13.9% of cases, which gives grounds for considering them opportunistic bacteria. Sharply pronounced correlation between the adhesive and pathogenic properties of Neisseria has been observed. The cytopathogenic action of Neisseria is accompanied by the lesion of the chromosomal apparatus of mitotic infected cells.

Amnion↗
PubMed1975

[The effect of diphtheria toxin on proliferation of a transplantable culture of human amnion cells].

Cytoxic effect (CTE) of diphtheria toxin (DT) is preceded by disturbances of proliferation process, this being expressed in reduction of the proliferation index (PI) and of mitotic index (MI) before the appearance of the CTE. The effect of the toxin on the proliferation and mitoses of the cell culture is expressed after the incubation period of about 3 hours. The extent and the rate of reduction of the indices directly depended on the dose of the toxin whose low doses at the early periods stimulated the proliferation. The maximum of all the manifestations of the toxin action coincided with the period of increased proliferation in control. On the basis of investigations carried out a hypothesis was put forward that the CTE of diphtheria toxin developed with the entrance of the cells into mitosis.

Amnion↗