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Biomedical subjects

G R Hogan

Publications and source records attributed to G R Hogan.

14 recordsLinked to original sources
PubMed1992

Cadmium treatment and lead-induced suppression of splenic erythropoiesis.

Young adult female mice were injected with lead acetate (d 0). Following injection, determinations were made of the percentages of radioactive iron (59Fe) uptake into the hemoglobin of erythrocytes produced by spleen. Control 59Fe uptake percentage vacillated between 4.2 and 5.5 within the 7-d period of observation. On d 4 following lead treatment, splenic percentages were dramatically reduced below those of the saline-injected controls; by d 6 the splenic 59Fe uptake of lead-treated mice was comparable to that of controls. For rodents injected with cadmium chloride on 0, the 59Fe uptake values showed a statistically significant elevation by d 2, which was extended beyond that of the controls' d 4 value. For those animals receiving both lead and cadmium (d 0), the uptake percentages paralleled those of the controls throughout the 7-d period of observation. These data suggest that the inhibitory effect of lead on erythropoiesis of the spleen is blocked by a concurrent cadmium treatment. Results are interpreted in regard to a possible vulnerable target and competition for the target by lead and cadmium.

Animals↗
PubMed1991

Cephalic replacement in severe shoulder dystocia.

In cases of severe shoulder dystocia, the outcome may be improved if cephalic replacement is attempted earlier. Severe shoulder dystocia is usually unresponsive to the traditional measures. Although still controversial, this maneuver may prove to be life-saving in an undeliverable fetus.

Adult↗
PubMed1990

Peripheral erythrocyte levels, hemolysis and three vanadium compounds.

Three vanadium compounds of different valence states were administered to adult mice. Two, four, and eight days following treatment of vanadium, cardiac blood was collected. The blood sample was used to ascertain the peripheral erythrocyte count (cell/mm3) and to determine the in vitro hemolytic index of erythrocytes obtained from mice treated in vivo with either the tri-, tetra-, or pentavalent vanadium compound. Data indicate that the tetravalent form was the most effective test substance in 1) promoting rupture of isolated erythrocytes compared to red cells retrieved from control mice and 2) depressing the erythrocyte count obtained from heart blood; maximum effects were manifest four days post-treatment. For all treatments there appeared to be a good correlation between the degree of vanadium-induced hemolysis and the peripheral erythrocyte count reduction following exposure to the vanadium.

Analysis of Variance↗
PubMed1989

Concurrence of limb girdle muscular dystrophy and myasthenia gravis.

We describe a case of limb girdle muscular dystrophy with associated myasthenia gravis. This association has not been previously noted in the literature. The unusual feature of the case was that symptoms coexisted for several years before a correct diagnosis was made. The diagnosis was based on the clinical picture and the results of the muscle biopsy and electrophysiologic testing. This case serves to illustrate the fact that a separate problem should be considered when the clinical picture is not compatible with the underlying diagnosis.

Biopsy↗
PubMed1985

Modified methods for preparation of cryostat sections of skeletal muscle.

We developed two modified methods for the preparation of cryostat sections of skeletal muscle: one using solid carbon dioxide and the other using the ultra-low freezer to prepare 2-methylbutane (isopentane) for freezing of skeletal muscle. The results were quite satisfactory, with good preservation of cellular details and histochemical properties. Freezing artifacts were minimal when compared with the standard liquid nitrogen method.

Adenosine Triphosphatases↗
PubMed1979

Lead-induced leukocytosis in female mice.

Lead acetate was shown to stimulate a striking leukocytosis in young adult female mice. The effect was manifest 4 days after lead injection and continued throughout the following 4 days. At the higher treatment level, lead induced an increase of 300% for both monocytes and neutrophils. The leukocytosis was due primarily to the elevated levels of neutrophils as suggested by a decrease in the ratios of peripheral agranulocytes to granulocytes. No differences from normal leukocyte cytology were observed in blood samples collected from animals receiving lead.

Animals↗
PubMed1979

Aflatoxin B1; its role in the etiology of Reye's syndrome.

Seven cases of Reye's syndrome in which aflatoxin B1 was isolated from the blood or liver or both are presented. In two cases aflatoxin B1 was found in the blood during the acute phase of the disease; a finding not previously reported. In six cases aflatoxin B1 was recovered from autopsy specimens of liver. A number of case reports linking aflatoxin B1 to Reye's syndrome have appeared in the literature but until now only one case had been reported from the United States. Aflatoxin B1 and its possible role in the etiology of Reye's syndrome is discussed. It is concluded that Reye's syndrome is the result of multiple interrelated factors.

Aflatoxins↗
PubMed1977

Single lead acetate insult, testosterone therapy, and erythropoiesis in mice.

Lead acetate (PbAc) was tested for its effects on the production and release of erythrocytes-that is, erythropoiesis-in ICR mice. Dose-survival data indicate that a dosage of 20 mg PbAc/100 g body weight represents the maximum tolerable treatment level. No differences in survival at the various levels of the salt were observed with regard to sex or age. For erythropoietic effects of PbAc, mice were injected on day O, and radioiron (59Fe) incorporation percentages were determined at daily intervals through day 8 for both erythrocytes and splenic tissue. Control mice received isotonic saline as the injectate. On day 3, the percentages obtained from PbAc-treated mice showed a decline, reaching their minimum value by day 4. Recovery from erythropoietic suppression appeared to be complete by day 6 or 7; no positive overshoots in 59Fe percentages were found following recovery. These trends were typical for both peripheral red blood cells and spleen. Testosterone was administered to mice receiving saline or PbAc on two consecutive days (days -1 and O). Radioiron uptake percentages for females receiving testosterone and saline showed an abrupt increase on day 4. No accelerative effect due to testosterone was found in recipient males. For females treated with testosterone and PbAc, the radioiron percentages for erythrocytes and spleen paralleled those for females receiving saline only. Male mice treated with both androgen and PbAc demonstrated 59Fe percentages typical of males treated with PbAc alone.

Animals↗
PubMed1977

Neurological evaluation of the newborn.

The neurological examination is an integral part of the evaluation of the newborn infant. In too many instances the infant is dismissed from the nursery as 'normal' when,in fact, little or no effort has been expended to determine the body's neurological status. The neurological deficits overlooked often do not become overt until a much later age. Early detection can prevent the mental anguish that plagues the parents who must be told that their 'normal' infant has significant neurological problems. In some instances early diagnosis may lead to a better ultimate prognosis. We have presented a simple scheme for the neurological evaluation of the full-term infant and hope that it will be useful in encouraging pediatricians to assess neurological status.

Cephalometry↗
PubMed1976

Hypernatremia--problems in management.

Hypernatremia may be produced under several different circumstances but most frequently is the result of excessive water loss with diarrhea and the excessive solute load secondary to inappropriate preparation of formula. The clinical manifestations vary and depend primarily on the degree of dehydration and the rate at which the hyperosmolar state has been reached. The management of the patient will, of course, depend upon the mechanism of hypernatremia and degree of dehydration and/or hypovolemia that is present. It seems clear that the exact nature of the rehydrating solution is not of major importance. The volume is of great concern but most vital seems to be the rate of rehydration. If rehydration is accomplished too rapidly the child becomes edematous, develops increased intracranial pressure, stupor, and convulsions. If fluids are given slowly and at a well regulated rate, these complications can usually be avoided. The patient should be monitored regularly with electrolytes, careful determination of weights, and records of intake and output. The rate of rehydration should be monitored to assure that the planned schedule of 24 to 72 hours (depending on the severity of the problem) is followed. Approximately 10 to 15 per cent of children with serum sodium of 160 mEq per liter or greater will have permanent neurological deficits.

Brain Diseases↗