Biomedical subjects
G R Kennedy
Publications and source records attributed to G R Kennedy.
Comparison of the orally administered anti-allergy agent, ketotifen with sodium cromoglycate in the prophylaxis of bronchial asthma.
Ketotifen at an oral dose of 1 mg twice daily was compared with sodium cromoglycate a dose of 20 mg four times daily by inhalation in a double-blind parallel group study lasting 12 weeks. Data relating to 60 patients were analyzed and showed that stabilised asthmatics continued to be stable during the 12-week treatment period on both drugs. There was a significant reduction within the ketotifen group in day and night scores at the end of the 12-week period and more patients on ketotifen had increased evening peak expiratory flow rate values compared with sodium cromoglycate. Ketotifen and sodium cromoglycate were equally well tolerated.
Poly(N-acryloyl-4- and -5-aminosalicylic acids. II. Antibacterial properties and uses for the preparation of active, insoluble antibiotics.
The antibacterial properties of poly(N-acryloyl-4- and -5-aminosalicylic acids) and their borate complexes were evaluated. Poly(N-acryloyl-4- and 5-aminosalicylic acids) were used to render the antibiotics streptomycin and gentamicin insoluble. The antibacterial properties of the resultant water-insoluble streptomycin and gentamicin derivatives were evaluated, and the results show that the polymers are suited to the preparation of active insoluble antibiotics. Potential antimicrobial applications of the polymers are discussed.
Structure of an iron-dextran complex.
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The distribution and nature of iodine compounds in ascidians.
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