Concealed breast cancer causes delayed treatment.
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Biomedical subjects
Publications and source records attributed to G R McLatchie.
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In order to assess the management of knee injuries in a sports medicine clinic, an audit was performed of all new patients who attended the clinic over a 12-month period. Of the 167 new patients seen, 76 (46%) had sustained knee injuries. Of these, 43 (57%) were treated in the sports medicine clinic and 33 (43%) were referred for arthroscopic assessment. The maximum waiting time from the time of referral was 3 weeks, with 85% of patients seen within 1 week and 92% within 2 weeks. Arthroscopy was performed on 28 (85%) of the 33 patients referred, and the positive correlation between the sports clinic diagnosis and the arthroscopic diagnosis was 64%. Of the 33 patients referred for arthroscopy, 28 (85%) had sustained acute knee injuries while five (15%) had been treated at other hospitals before referral to the sports medicine clinic. A National Health Service sports medicine clinic is an effective means of treating knee injuries, provided that access to arthroscopy is readily available.
Scapula winging is an uncommon condition but one which may be underdiagnosed. Four patients with scapula winging referred to a sports injury clinic are presented. None of the patients was aware of any trauma and a traction injury to the long thoracic nerve is proposed as the aetiology of this condition. These case reports emphasize the importance of excluding winging of the scapula in patients who present to sports injury clinics with shoulder pain.
The cause, management and outcome of 23 patients with a pancreatic fistula following acute pancreatitis are reviewed. Nineteen patients developed an external fistula following necrosectomy or drainage of a pancreatic abscess or pseudocyst; four of these patients died. In the 15 survivors spontaneous closure occurred in 11 cases with low output fistulae; operative intervention was needed in the four cases with high output fistulae. Four patients with internal fistulae had not undergone previous surgery; two of them had a pancreaticopleural fistula with associated pancreaticogastric fistulae, while two had pancreatic ascites. All four of these patients required surgical intervention and one died.
Two hundred and thirty-one patients with acute soft tissue injuries were treated in a double-blind placebo-controlled study of felbinac (biphenylacetic acid) gel applied three times daily to the injured site. Those treated with felbinac had significantly greater improvement at Day 4 (p less than 0.001) and Day 7 (p less than 0.02) than those who received placebo. Patients' self-assessment diary cards confirmed superiority of the active treatment as early as Day 2 of the study. Local skin reactions were few (three per cent), mild and recovered spontaneously. Felbinac is an effective management for acute soft tissue injuries and because of its topical application may be safer than oral non-steroidal anti-inflammatory drugs for the treatment of these conditions.
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We have analysed the effects of 'curative' and palliative surgery and adjuvant therapy on actuarial 5 and 10 year survival in 97 local patients with primary small bowel malignancies presenting to five Glasgow teaching hospitals over a 15 year period. The 5 year survival rates in 18 patients with lymphoma undergoing 'curative' surgery was 48 per cent while in patients whose surgery was considered palliative the figure was 12 per cent (P less than 0.001). In the 29 patients with carcinoma, 17 had 'curative' surgery and 12 a palliative procedure with respective 5 year survival rates of 38 per cent and 0 per cent (P less than 0.01). In 16 patients with carcinoid tumours the surgeons' assessment of curative or palliative surgery was of little consequence with 51 per cent of the palliative group alive at 10 years. Mean survivals were increased in lymphoma patients in both 'curative' and palliative groups receiving adjuvant therapy but not significantly so. We suggest that all detectable macroscopic tumour, where possible, should be removed and that adjuvant therapy may be of benefit in all patients with lymphoma, even when surgery is considered 'curative'.
In an open study 50 patients were treated for a variety of infections with 3.2 g Timentin 6, 8- or 12-hourly for a mean period of six days. Timentin was clinically successful in 87% of patients assessed at the end of treatment of whom 95% remained cured or improved at a later follow-up. Bacteriologically Timentin was successful against 92% of organisms, including all 11 which were ticarcillin or ampicillin resistant. Side effects were reported in seven patients, the majority of which were minor local reactions at the site of infusion. This open study shows Timentin to be a safe and effective antibiotic for the treatment of infection.
In a questionnaire study of 1,559 English professional footballers, the incidence of cigarette smoking was found to be much lower than the national average. Of those surveyed only 5% admitted to cigarette smoking. Smoking was much lower in First Division Clubs (3.2%), and higher in Fourth Division Clubs (6.9%). It is suggested that these figures could be used in a national campaign to promote non-smoking amongst young people who follow football.
In a study of 144 patients, with Grade 1 and 2 inversion injuries to the ankle sustained in sport, treatment with a non-steroidal anti-inflammatory was considerably superior to placebo with respect to joint tenderness, level of training and injury severity. No difference in efficacy could be determined between ibuprofen 2400 mg given in two or four equally divided daily doses. Ten patients withdrew from the study because of side effects, five from ibuprofen twice daily, three from ibuprofen four times daily and two from the placebo group. This study confirms the efficacy, flexibility and tolerability of high dose ibuprofen.
Three patients are presented in whom internal pancreatic fistulae were accurately demonstrated by ERCP. It is recommended that this procedure be considered in the investigation of patients with continuing acute pancreatitis who are not settling on standard conservative treatment and in whom internal fistula formation is suspected. The procedure should also be considered in patients who present with unusual respiratory symptoms or with amylase-rich effusions.
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A patient with Clostridium welchii infection complicating intestinal angina is reported. Surgical resection of bowel of dubious viability is important to avoid this unusual complication.
Acute pancreatitis is an unusual feature of non-pancreatic neoplasia. The presentation and clinical course of 7 patients with carcinoma metastatic to the pancreas is reported. In 5 the initial presentation was acute pancreatitis, and in the remaining 2 the diagnosis was made at autopsy. The primary sites of cancer were in the stomach (5 patients), bronchus (1 patient) and tonsil (1 patient).
Pneumothorax is a well known immediate complication of penetrating chest injuries, but its late occurrence is not widely recognized. In a retrospective study of 56 patients who sustained stab wounds of the chest, 6 (10 per cent) developed pneumothorax between twelve hours and three days after injury. Combined thoraco-abdominal stab wounds were present in three patients and surgical emphysema was also apparent in three other patients. We conclude that pneumothorax of late onset may be commoner than has been suspected and this emphasizes the need for observation in hospital for 48 h and for serial radiography of the erect chest to detect this dangerous complication.
In a retrospective study carried out at the Royal Hospital for Sick Children, Glasgow, for the period 1952-79, 7 cases of primary thoracic neuroblastoma were identified. The average age at presentation was 2 years. Respiratory symptoms were the modes of presentation in 2 patients, neurological symptoms in 4, and urinary tract symptoms in 1 patient. Dilatation of the urinary tract was present in 2 cases, and a third had a normal urinary tract but previous infections. After a maximum of 27 years and a minimum of 20 months, 5 of the patients remain well. One child died as a direct result of her tumour, the other from an unrelated tumour 25 years after partial excision of his neuroblastoma. The better prognosis of primary thoracic neuroblastoma and the variability of presentation compared with neuroblastoma in other sites are stressed.
A clinical and radiological study of upper and lower limb joints was carried out on 25 experienced weight-lifters to identify the extent of degenerative joint disease (Osteoarthrosis) produced by this sport. Although significant degenerative changes were found in five lifters (20%). This figure is not greater than that found in the general population within the age group studied. There were more degenerative changes found in Olympic style weight-lifters (30.7%) than in power lifters (8.3%). The significance of these figures is discussed. The upper limb joints were almost completely free of degenerative changes.