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Biomedical subjects

G R Monif

Publications and source records attributed to G R Monif.

At least 19 recordsLinked to original sources
PubMed1991

Intrapartum bacteriuria and postpartum endometritis.

Ten gravidas with bacteriuria in the immediate antepartum period subsequently delivered vaginally and did not receive antibiotic therapy. Four of these women developed postpartum endometritis and in three of them, the same Enterobacteriaceae recovered from the urine was present in the endometrial cultures. Of the 1233 study subjects whose screening urine cultures were negative and who delivered vaginally, 27 (2.2%) developed endometritis. Intrapartum bacteriuria was significantly associated with postpartum endometritis in women delivering vaginally (P less than .001). Monitoring for asymptomatic bacteriuria and eradicating it in pregnancy should diminish the occurrence of endometritis and possible endomyometritis in the postpartum period.

Bacteriuria↗
PubMed1989

Potential use of C-reactive protein determinations in obstetrics and gynecology.

C-reactive protein (CRP) is an acute-phase protein synthesized by the liver during the course of a large number of diseases. During gestation and parturition, progressively increasing numbers of gravida develop elevated levels up to 32, 48 to 80 per cent, respectively). These elevations in pregnancy, the nonspecificity of the test, and the inability to function as a reliable marker of fetal and/or maternal infectious morbidity have obscured the pragmatic utility of CRP determinations in both obstetrics and gynecology. Because of its biophysical kinetics, C-reactive protein determinations are best used as a monitoring parameter after the documentation of infection rather than as a diagnostic indicator of infection. They can provide valuable end titration points for termination of parenteral antibiotic therapy.

C-Reactive Protein↗
PubMed1989

In vitro sensitivity of Candida (Torulopsis) glabrata to clotrimazole.

Vulvovaginitis caused by Candida (Torulopsis) glabrata is often refractory to intravaginal imidazole therapy. Clotrimazole achieves its fungistatic activity for Candida albicans and C. glabrata by inhibiting different steps in intermediary cell metabolism. For C. glabrata, alkylation precedes dimethylation. The possibility that this altered sequence might account for the relative therapeutic nonresponsiveness was studied by determining comparative minimal inhibitory concentrations (MICs) of clotrimazole. In vitro analyses of ten strains of C. glabrata and 30 control strains of C. albicans performed using both agar and broth dilution tests revealed that four-fold lower MICs were consistently demonstrable with C. glabrata, irrespective of inoculum size. The data suggest that clinical difficulties encountered in the therapy of torulopsis vulvovaginitis probably represent the inability of intravaginal medication to eradicate urethral/urinary bladder colonization and subsequent reinfection rather than true therapeutic failures.

Candida↗
PubMed1989

How rare is congenital herpes simplex? A literature review.

Using three criteria--(1) herpetic infection and altered organogenesis of inflammatory etiology that antedates dissolution of the fetal membranes, (2) documented herpetic infection present at birth and within 24 hours of rupture of the fetal membranes, and (3) evidence of viral herpetic placentitis the induction of which antedates rupture of the membranes--15 cases of congenital transplacental herpes simplex were identified in the literature. Disease occurring early in gestation produces a cluster of congenital malformations that is clinically indistinguishable from that produced by the cytomegalovirus. Disease manifesting after the shortest recognized incubation period for the induction of the disease in experimental animals does not necessarily preclude transplacental acquisition. Various factors mask the perception of congenital transplacental herpes simplex as a valid disease entity.

Cohort Studies↗
PubMed1988

Perinatal septicemia due to the Bacteroidaceae.

Two cases of perinatal septicemia due to the Bacteroidaceae are discussed. In contrast to most cases of perinatal septicemia caused by aerobic bacteria, these cases were not associated with prolonged rupture of the fetal membranes.

Adolescent↗
PubMed1986

Spontaneous bacterial peritonitis associated with an intrauterine device.

Intrauterine contraceptive devices (IUD) have been associated with the induction of chronic anaerobic endometritis as well as superimposition of exogenous sexually transmitted diseases and unilateral tubo-ovarian abscesses. We report an unusual case of spontaneous bacterial peritonitis in a patient with ascites and an IUD. Bacteriological data support the concept that the source of infection was a chronic mixed endometritis induced by prolonged use of an IUD (16 years). In the presence of ascites, a localized endometritis with its reservoir of bacteria provided the medium for systemic disease.

Ascites↗
PubMed1986

Short-term failure of IUD removal to alter bacterial flora in a patient with chronic anaerobic endometritis.

A patient with cytological and clinical evidence of IUD-associated anaerobic endometritis was studied with quantitative and qualitative bacteriological techniques. With the exception of elimination of Actinomyces israelii from the deep endocervical/endometrial culture, IUD removal induced minimal qualitative changes in the bacterial flora of the endocervical/endometrial sample during the 35 days the patient was monitored. The interposition of menstruation did not significantly alter either the quantitative or qualitative interrelationship of the bacteria present.

Adult↗