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Biomedical subjects

G R Mufti

Publications and source records attributed to G R Mufti.

At least 37 records · Page 2Linked to original sources
PubMed1996

Interstitial cystitis in men.

Interstitial cystitis is an uncommon disease reported predominantly in females. Recently we were involved in the management of 4 men who had the clinical, endoscopic and pathological features consistent with the diagnosis of interstitial cystitis. The rarity of occurrence of the disease in males prompted us to report these cases.

Cystitis, Interstitial↗
PubMed1993

Transurethral resection for a large prostate--is it safe?

A retrospective self-audit exercise was undertaken on 47 men who underwent transurethral resection of the prostate and in whom the resected weight was 80 g or more. The operative mortality and morbidity rates were 6 and 55% respectively, being highest in the "very old and unfit" group (22 and 88%). The complication rate increased if the resected prostatic weight was 100 g or more, or if the resection time exceeded 75 min. It was concluded that careful selection of patients is necessary before undertaking TUR for a large gland.

Aged↗
PubMed1992

Giant pre-sacral neurofibroma.

We report a case of pre-sacral neurofibroma diagnosed on a routine medical examination. The pathological features and management criteria of these rare tumours are discussed.

Humans↗
PubMed1992

Value of random mucosal biopsies in the management of superficial bladder cancer.

115 newly diagnosed patients with Ta-T1, G1-G2 superficial transitional cell carcinoma of the bladder underwent four quadrant biopsies of normal-looking bladder mucosa, in addition to the endoscopic treatment of the primary tumour or tumours. In 88 (77%) patients all the biopsies were normal; in the other 27 (23%) at least one biopsy revealed dysplasia or carcinoma in situ or G1-G2 carcinoma. 88 patients presented with a single tumour, of which 14 (16%) had abnormal biopsies compared to 13 (48%) of the 27 presenting with multiple tumours. The difference between the 2 groups was statistically significant (p < 0.01). The incidence of freedom from new tumours at 5 years was 68% in patients with normal biopsies compared to 33% in patients with abnormal biopsies (p = 0.002). In patients presenting with multiple tumours and in those with single tumours and abnormal biopsies, the incidence of freedom from new tumours was significantly lower than in those presenting with single tumours and normal mucosal biopsies (p = 0.002). The study shows that the exercise of performing random mucosal biopsies is particularly useful in patients presenting with single tumours, in order to identify those who are more likely to develop new tumours over the longer term. Such patients could be offered early prophylactic intravesical chemotherapy. The study did not substantiate tumour implantation as a factor for new tumour development in superficial bladder cancer.

Adult↗
PubMed1990

Corporeal plication for surgical correction of Peyronie's disease.

A retrospective study was done on 30 patients who underwent surgical correction of the penile deformity secondary to Peyronie's disease between 1983 and 1988. Mean followup was 31 months (range 9 to 72 months). Nine patients (30%) underwent Nesbit's operation, 8 (27%) had incision and transverse closure of the tunica albuginea and 13 (43%) had corporeal plication. Over-all, 19 patients (63%) improved postoperatively, which implied erection free of pain with minimal or no deformity and the ability to perform normal sexual intercourse. Presence of pain with deformity was an important factor that influenced the surgical result and should be regarded as a contraindication to surgical intervention. The results of corporeal plication were as good as the other 2 methods. The advantages of this procedure over the other 2 methods are discussed. We recommend this procedure for patients in whom surgical correction of the deformity is indicated.

Coitus↗
PubMed1990

Long-term follow-up of intravesical Epodyl therapy for superficial bladder cancer.

The records of 111 patients with multiple superficial grade 1-2 transitional cell tumours of the bladder treated with intravesical Epodyl and followed up for a mean period of 6.4 years were retrospectively analysed. The study showed that 65% of patients responded completely after 12 weekly instillations and 46% of these remained continuously free of disease for 5 years. An initial complete response to therapy and lower pathological grade seemed to indicate a long-term successful response to treatment. In patients who failed to respond by 1 year, further therapy was of no benefit. Clearance of bladder disease by 1 year carried a 14% risk of subsequent tumour invasion by 5 years. This risk increased to 75% in those who failed to respond by 1 year.

Administration, Intravesical↗
PubMed1990

Diagnosis of clinically occult bladder cancer by in vivo staining with methylene blue.

In vivo staining of the bladder mucosa with 0.1% methylene blue in normal saline was performed on 23 randomly selected patients with known and previously treated transitional cell tumours of the bladder in whom routine check cystoscopy failed to demonstrate any mucosal abnormality. In 21 patients differential staining of the bladder mucosa resulted, with no mucosal staining in 2. Cold cup biopsies were obtained from stained as well as unstained areas. Although positive staining did not prove the presence of a pre-malignant or malignant area, lack of staining was more likely to exclude mucosal abnormalities.

Carcinoma, Transitional Cell↗
PubMed1990

Granulomatous orchitis. Review of 15 cases.

Granulomatous orchitis is a rare lesion of the testis which can clinically simulate malignancy. The clinical, radiological and pathological features of 15 patients are presented and discussed.

Adult↗
PubMed1990

An unusual case of adrenal cortical carcinoma.

We describe a case of non-functioning adrenal cortical carcinoma, which recurred 16 years after surgical adrenalectomy. In addition, the patient was successfully treated for two anatomically separate and histologically different, primary malignant tumours. This case highlights the importance of lifelong follow-up after apparently curative surgical excision of an adrenal tumour.

Adrenal Cortex Neoplasms↗
PubMed1990

'Solitary' Ta-T1 G1 bladder tumour--history and long-term prognosis.

Natural history of 'solitary', histological grade 1, stage Ta-T1 transitional cell carcinoma of the bladder was studied in 198 patients retrospectively over a period from 1975 to 1987. Three patterns of tumour behaviour were evident. In 56% of patients the tumour did not recur following the initial resection. Twenty-one percent developed recurrences localised to the site of the original tumour. This group became tumour-free by 5 years and remained so thereafter. The remaining 23% continued to produce recurrent tumours up to 10 years at different sites in the bladder. The actuarial percentage of patients who remained continuously free of tumour after the initial resection was 53% at 5 years and 51% at 10 years. The results of this study suggest that cytoscopic follow-up may be discontinued in patients who remain continuously tumour-free for 5 years.

Adult↗