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Biomedical subjects

G R Selby

Publications and source records attributed to G R Selby.

12 recordsLinked to original sources

Perceived sources of stress among dental students.

A survey of dental students' perceptions of stress indicates that academic factors and faculty relationships with students are the areas that create the most stress. Differences between the four classes in the ranking of several areas reflect the differences in academic and clinical requirements and experience associated with each class.

Dental Care↗

A survey of career assistance programs at U.S. dental schools.

1. There is a perceived need among the leaders of our dental schools for career assistance programs for dental students. 2. Current programs and services for transmitting career assistance at a majority of dental educational institutions are either nonexistent or sporadic, and handled informally without carefully coordinated activities. 3. The most frequently used career assistance services, where programs do exist, are a library of career informational materials, formalized arrangements with outside professionals in the community, and placement services. 4. Among the variety of individuals coordinating current programs in career assistance in dental schools, the most common is a member of the administration (primarily the director of student affairs).

Career Choice↗

Immune expulsion of Trichuris muris from resistant mice: suppression by irradiation and restoration by transfer of lymphoid cells.

Lethal irradiation (850 rads) of mice made resistant to Trichuris muris markedly depressed their ability to expel a challenge infection. Expulsion was restored within 7-10 days when MLNC from uninfected mice were transferred on the day of infection, but no significant restoration was evident after transfer of immune serum. Transfer of BM alone had no restorative effect within 10 days and no synergism was seen when both BM and MLNC were transferred. MLNC from uninfected donors did not restore challenge expulsion when transfer was delayed until day 7 and the mice were killed 3 days later, although MLNC from resistant donors were effective within this time. When irradiated mice were given BM and the challenge infection allowed to continue for 15 days expulsion was restored, as it was when challenge was delayed for 7 days after BM transfer in thymectomized mice. The results confirm that expulsion of T. muris involves both antibody-mediated and lymphoid cell-mediated phases and offer no evidence for the involvement of other cell types.

Animals↗

Suppression of the immune response to Trichuris muris in lactating mice.

Mice infected with Trichuris muris during lactation were unable to expel the infection at the normal time, but expulsion occurred when lactation was terminated. Suppression of expulsion was uniform in mice suckling more than five young but variable with smaller litters. Mice exposed to a primary infection while lactating were shown to have serum antibodies capable of passively transferring immunity to recipient mice and showed near normal immunity to a secondary infection given after lactation had ceased. Acquired immunity to T. muris was also suppressed by lactation, but the worms which became established in lactating resistant mice were fewer and smaller than those in non-lactating, non-resistant controls. It is suggested that the suppressive effect of lactation in this host-parasite relationship is exerted on the second, lymphoid cell-mediated phase of worm expulsion.

Animals↗