Biomedical subjects
G R Voogt
Publications and source records attributed to G R Voogt.
Ototoxicity of aminoglycoside drugs in tuberculosis treatment.
The possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an Audimax 500 audiometer. At the so-called "safe" levels of drug administration it was found that kanamycin was markedly ototoxic, streptomycin very slightly ototoxic and the standard anti-TB drug combination had practically no ototoxic effect. Furthermore, it was found that none of these drugs were gender specific. Lastly, the possible effects of ageing on highest audible bone conduction frequency is discussed.
Tentative age-related norms for high frequency electric bone conduction audiometry.
From 172 male and female patients aged 7-71 years old and admitted in one month to a tuberculosis hospital, 150 had their highest audible electric bone conduction (EBC) frequency evaluated, prior to the commencement of any medical treatment. Various problems in establishing high frequency norms are discussed and from the results of this study tentative age-related highest frequency EBC norms are suggested. Possible clinical applications of evaluating the highest audible EBC frequency is suggested.
Prevalence of otitis media in a Venda village.
During mid-winter in 1985, 263 children and 217 adults from a remote rural community in Venda, were examined for the presence of middle ear lesions by: pneumatic otoscopic examination; tympanometry; and contralateral acoustic reflex. A diagnostic algorithm was applied to assess the findings. The prevalence of otitis media (OM) in children (less than or equal to 15 years) was 8.4% and in adults (greater than 15 years) 2.3%, with the highest figure in the 0-23 months age group. OM with effusion was found in 3.6% of the children. Our data suggest the existence of considerable differences in the prevalence of OM between comparable black rural communities.
Early detection of ototoxicity by high-frequency audiometry--a case study.
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Prevalence of otitis media in children in a black rural community in Venda (South Africa).
During mid-winter in 1985, 480 residents from a remote rural community in Venda, South Africa, were examined for the presence of middle and external ear pathology. The children (less than 15 years) numbered 267. The otological examination consisted of (1) pneumatic otoscopic examination, (2) tympanometry, (3) contralateral acoustic reflex. A diagnostic algorithm as proposed by Cantekin et al. was applied to assess the findings. Our data showed the prevalence of otitis media in children to be 8.2%. The highest prevalence was found in the 0-23 months age group. Of 22 children with otitis media, only one had a perforation with otorrhea. Otitis media with effusion was found in 3.8% of the children. External otitis media as an independent variable was found in only 1.5% of the 267 children, while 6.7% presented with scarred tympanic membranes. Our data suggest the existence of considerable differences in the prevalence of otitis media in children between two comparable black rural communities from Nigeria and Venda.
Immittance screening in black preschool children attending day-care centres.
Immittance screening was performed on 736 black children between the age of 2 and 6 years attending four day-care centres. It was found that 14.9% of these children failed the immittance screening. Problems encountered when attempting to apply the available standard immittance screening pass/fail criteria to a specific black race group are discussed.