Biomedical subjects
Publications and source records attributed to G Radosavljević.
Pseudomyxoma peritonei is a rare clinical manifestation of mucin producing adenocarcinomas. An extensively metastased adenocarcinoma developed a pseudomyxoma that affected not only the peritoneal cavity but also the pleura.
Anti HMFG1 monoclonal antibodies labeled with 99mTc were used for the detection of non-small cell lung cancers and their metastases in 18 patients (12 squamous cell cancers, 2 large cell lung cancers, 1 adenocarcinoma and 3 undifferentiated non-small cell lung cancer). According to performed therapy all patients were divided into three groups: group 1 consisted of 13 patients who had not received chemotherapy or radiotherapy before immunoscintigraphy (IS), group 2 included 3 patients who had undergone IS during external beam radiotherapy, and group 3 (two patients) who had received both chemotherapy and radiotherapy before IS. After antibody administration planar scintigraphy of the head and neck, chest in anterior and posterior projection, anterior abdomen, pelvis, thighs and calves was obtained at 10 minutes, 5 hours and 24 hours. The scans were interpreted semi-quantitatively using T/NT ratio. In the first group IS was found true positive in 5/13 patients (38%), and T/NT ratio ranged from 1.3-1.5. In the second group all three patients were true positive and T/NT ratio ranged from 1.76 to 2.1. In the third group both patients were found false negative. Successful metastases detection was found in 4/13 patients (30%).
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A case is presented of 41 year old patient with a very rare form of clinical manifestation of adenocarcinoma with a large mucinous ascites with abdominal distention and a massive left hemithoracic content with same characteristics. Two years prior the patient suffered from acute abdomen and underwent apendectomy with slow wound healing and a stomach edema 6 months later with a finding of smaller changes on the left side of the thorax. The patient was hospitalized when he already had an advanced stage of the disease. The diagnosis of adenocarcinoma was reached with percutaneous thoracic biopsy and finding of mucinous malignant cells. Gelatinoid ascites was confirmed on CT an echography with the same finding in the thorax. Systemic chemotherapy was initiated without major effect followed by intrapleural and intraabdominal instillation of hyaluronidase in combination with cytostatics. The course of the disease and treatment effects were followed echographically and on CT. According to available literature this is the first case report of a patient with mucinous adenocarcinoma and a presentation of pseudomyxoma of the thoracic and abdominal cavities.
The report presents the analysis of TB patients treated at the Institute for lung diseases and tuberculosis of SR of Serbia during 1988--a total of 567 or 10.18% of discharged patients. There were 77% TB patients from Belgrade and 23% from the province. Tuberculosis retains the characteristics of a social disease with a morbidity peak in the fourth decade of age. There were 93% of cases discovered due to disease symptoms. In 82% of patients it was a case of newly discovered specific process, 7.5% had a recurrent disease and 10.5% of patients had a chronic form of the disease. The patients had almost all forms of the specific process: primary tuberculosis 0.35%, postprimary phthisis 84.4%, specific pleuritis 10.6%, tuberculom 1.9%, miliary tuberculosis 1.8%, lymphoglandular tuberculosis 0.9%, while 1.4% had extrathoracic specific lesions associated with pulmonary lesions. Cavernous tuberculosis was observed in 89% of TB patients and extensive phthisis in 14% of cases. Atypical forms of parenchymal specific process were observed in 12% patients. Bacteriological or histological confirmation of tuberculosis existed for 82%. In 13% of patients treatment lasted longer than 3 months. Six or 1% of patients died due to pulmonary tuberculosis.
A case of Dressler's syndrome which has developed in a patient with bronchogenic carcinoma during radiotherapy is presented. Diagnosis is established according to symptomatology, clinical findings, chest X-ray, laboratory analysis and immunological findings. Existence of metastatic deposits in heart is excluded by the method of echocardiography. Short-term cardiologic therapy with antiflogistics is completely sufficient for maintaining the stability of "cardiologic status".
Pseudomonas aeruginosa is an ubiquitous microorganism, which is characterised with low virulence and moderately sensitive to antibiotics. Significance of identification of the bacteria in the sputum varies. In severe cases, exhausted by more simultaneous diseases, it can be manifested as a pathogenic agent. At the Institute of Pulmonary Diseases and Tuberculosis, UCC in Belgrade Pseudomonas was isolated in the sputum samples of 48 patients. The organism was apathogenic in 28 (59%) cases, in 17 (35%) cases it caused chronic suppuration, and in 3 (6%) pneumonia. No specific antipseudomonas therapy is needed in patients in good general condition, contrary to cases of manifested infection where two antibiotics, physical therapy and other measures are indicated. Basic disease determines prognosis of the infection course. Medical approach to this problem should be characterised by prevention of the infection occurrence.
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