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G Rai

Publications and source records attributed to G Rai.

35 records · Page 2Linked to original sources
PubMed1991

The pharmacokinetics of cefuroxime axetil in the sick elderly patient.

The pharmacokinetics of cefuroxime axetil (RS3 formulation) were studied in 20 elderly patients following admission for lower respiratory or urinary tract infection. The mean age was 83.9 years. A 12-hourly dose of 250 mg was given for five days. The mean time to attain maximum serum concentration was 3.2 h with a mean peak concentration of 8.5 mg/l. The mean serum elimination half-life was 3.5 h and the AUC0-infinity 60.4 mg/h.l. There was no accumulation of the drug in the patients studied after five days treatment. The data suggest that the standard dosage regimen is adequate in the sick elderly patient.

Administration, Oral↗
PubMed1990

Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia.

A randomized, double-blind, placebo-controlled, parallel-group clinical trial was carried out to compare 24-week periods of treatment with 1 g acetyl-l-carnitine twice daily and placebo in the treatment of patients with dementia of the Alzheimer type. A total of 36 patients entered the trial, of whom 20 patients (7 active, 13 placebo) completed the full 24 weeks. Whilst several of the efficacy indices showed little change in either group during the trial, there was an apparent trend for more improvement in the acetyl-l-carnitine group in relation to the Names Learning Test and a computerized Digit Recall Test, both related to aspects of short-term memory. Similarly, there was a trend for reaction time in the computerized classification test to show less deterioration in the active treatment group. Changes within groups, and changes between groups, failed to reach statistical significance, at least partially because of the small number of patients available for analysis. Two indices of overall therapeutic benefit showed a trend for less deterioration in the active-treatment group than in the placebo group. Nausea and/or vomiting occurred in 5 patients in the acetyl-l-carnitine group. Laboratory tests revealed no signs of drug toxicity. The results suggest that acetyl-l-carnitine may have a beneficial effect on some clinical features of Alzheimer-type dementia, particularly those related to short-term memory.

Acetylcarnitine↗
PubMed1988

Evaluation of imipenem/cilastatin for treatment of infection in an elderly population.

Eighty-seven episodes of infection occurring in 83 patients were treated with imipenem as the sole antibiotic (1.5-4 g daily). All patients were aged 65 years or over, many with other non-infective diseases. A favourable clinical outcome (infection cured or improved) was obtained in 88% of cases. Of the 37 patients who were microbiologically evaluable, a favourable clinical outcome occurred in 92% and a favourable bacteriological outcome (pathogen eradicated or suppressed) occurred in 86% of cases. There were 13 deaths amongst the study group, which might be expected in an ill elderly population. None of the deaths was thought attributable to imipenem. Minor clinical side effects occurred in 10.6%, and one patient sustained a cerebral ischaemic episode and fits, possibly related to imipenem. No serious changes were detected in laboratory parameters.

Aged↗
PubMed1987

Haematological abnormalities induced by feeding a common artificial sweetener, saccharin, in ICR Swiss mice.

Haematological studies were carried out to investigate the possible deleterious effects of an extensively used artificial sweetener, saccharin, on albino mice, after feeding it for 1 year at the rate of 0.0 (control), 0.5, 1.0 and 1.5 g/kg body weight/day. Feeding of the chemical at 1.0 and 1.5 g/kg/day revealed a marked decrease in total erythrocyte count (TEC), haemoglobin content (Hb) and packed cell volume (PCV), suggesting the occurrence of anaemia. Differential leucocyte count (DLC) showed a marked increase in the number of polymorphonuclear neutrophils. Saccharin toxicity, in terms of induction of haematological abnormalities in albino mice, is discussed.

Anemia↗
PubMedDate not supplied

Synthesis and biological activity of 6-substituted-3-[2-(5-substituted-2-furfurylidenehydrazino)-4-thiazolyl] coumarins.

A series of coumarin-derivatives (5) were synthesized by the reaction of 5-substituted-2-furfuraldehyde thiosemicarbazones with 3-bromoacetyl-6-substituted coumarins. The structures of newly synthesized compounds were confirmed on the basis of their elemental analysis, NMR and mass spectral data. Some selected compounds were screened for their antibacterial activity employing disc diffusion technique.

Anti-Bacterial Agents↗