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Biomedical subjects

G Randzio

Publications and source records attributed to G Randzio.

13 recordsLinked to original sources
PubMed1991

[A comparative study between bone marrow scintigraphy and magnetic resonance tomography in oncologic patients].

In 35 patients with malignant bone or bone marrow disease, comparative BMS and MRT were performed. Both methods are useful for the early recognition of malignant changes in the skeleton, frequently at a stage when radiographs and bone scans are still negative. BMS provides a global picture of the marrow and can demonstrate focal or diffuse defects within malignant infiltration. Portions of the skeleton which do not contain erythropoietic marrow, or those obscured by high liver or spleen activity, cannot be evaluated. MRT shows the highest sensitivity. The lesions are usually characterised by circumscribed low signal (T1) or high signal (T2) areas. The size and extent were accurately demonstrated. Definite information regarding malignancy was not possible by MRT alone. The method is limited because it is slow, expensive and not easily available. MRT should therefore be reserved for specific problems and is not suitable for examination of the entire bone marrow as, for instance, for staging.

Adult↗
PubMed1991

Fractionated beta-irradiation of a conjunctival lymphangioma.

Fractionated beta-radiation was applied on a conjunctival lymphangioma, which had been known for several years. Histological diagnosis was established 3 years previously. Excision was not possible because the tumor had involved a considerable part of the conjunctiva. Using a strontium-90 applicator a total dose of 30 Gy was applied in 6 fractions with 5 Gy each. The initial tolerance was satisfactory. No radiogenic damage occurred, an involution of the tumor could be observed. During a follow-up time of nearly 2 years no further progression was noted. We consider the beta-radiation as an interesting therapeutic alternative for conjunctival lymphangiomas which are difficult to treat surgically due to their size.

Beta Particles↗
PubMed1988

Does active rheumatoid arthritis affect intestinal iron absorption?

One of the causes of anaemia in rheumatoid arthritis is thought to be defective iron absorption. In this study the 59Fe absorption in patients with active rheumatoid arthritis is measured and correlated with the results for bone marrow iron stores (and in some cases with the iron stores in the terminal duodenum), which were assessed simultaneously with semiquantitative methods, and with the serum ferritin concentration. In 11 patients with rheumatoid arthritis and increased bone marrow iron stores, iron absorption was decreased. In five patients it was normal and in three further patients, whose bone marrow iron stores were depleted, iron absorption was maximally increased. According to the results both intestinal malabsorption and defective iron absorption can be excluded as causes.

Adult↗
PubMed1986

The autoclaved autogenous bone graft as a re-implant. Results of animal experiments.

The use of autoclaved bone grafts was studied in animal experiments. First we checked the immunological response in inbred rats. No antigen-antibody reaction could be detected after syngenic and allogenic autoclaved bone grafting. The bone healing of autogenous autoclaved rib grafts of different length was tested in inbred dogs. After polychrome sequential marking we investigated the periosteal and endosteal osteogenic repair of the transplant-area using different histological techniques. Simultaneously we observed the slow destruction and lysis of the autoclaved graft. In our opinion the use of autoclaved autogenous bone graft is possible, under stable conditions, for immediate reconstruction of the mandible in tumour surgery.

Animals↗
PubMed1981

[Measurements of the surface dose for the irradiation of cultured cells with a Co-60 source (author's transl)].

In order to exactly determine the irradiation dose for cultured cells in culture containers (Petri dishes and others), it is necessary to have a detailed knowledge of the depth dose curve in water-equivalent layers near the surface. This curve was determined for Co-60 radiation by means of a window-less liquidity dosemeter. The dosemeter liquid was a solution of ammonium-iron (II) sulfate (solution of Fricke), the extinction of which was measured at 304 nm. Petri dishes were used instead of closed irradiation flasks. The distance QOA was 50 cm for all experiments, the field size was 10 X 10 cm. The depth dose maximum was found in a depth of 5,0 mm which corresponds to a mass of 0,50 g cm-2 relating to the surface. The surface dose was determined to be 39,2% and 106,6% of the maximum dose, respectively. This method can also be applied for closed culture containers (flasks).

Cells, Cultured↗
PubMed1976

Different renal oxidation rates of intramolecular carbon atoms in lactate and pyruvate.

In order to get more detailed information on the different renal modes of utilization of individual intramolecular carbon atoms, formation rates of 14CO2 and metabolic products from single-carbon labelled exogenous substrates have been studied in isolated tubular fragments from rat kidney cortex. The results showed that carboxyl groups from acetate, lactate, and pyruvate were converted to CO2 at a much higher rate than substrate-2-C or 3-C. This effect was not due to a physico-chemical splitting. The corresponding C-2 or C-3-atoms were incorporated into newly formed glucose to a higher extent than carboxyl groups. Apparently, the maximum chance to be converted to CO2 for an intramolecular carbon of an exogenous substrate lies at the stereospecific site of action of decarboxylating enzymes. With rising distance from this point the probability to be built into glucose (i.e. to escape the oxidative pathway) increases. Due to the different share of the intramolecular substrate carbon (in the total CO2 formation) without the use of single-carbon labelled substrates one cannot calculate the oxygen requirements for an observed 14CO2 formation.

Animals↗
PubMedDate not supplied

[Conclusiveness of various diagnostic procedures for squamous cell carcinomas of the visceral cranium and the oral cavity as compared with histological evaluations].

In 60 patients with primary squamous cell carcinomas of the oral cavity, clinical examination was complemented by 5 additional diagnostic procedures prior to surgery to assess tumor extension. Comparing these finding with the histological evaluation of the excised tissue demonstrated that, while the TNM classification remains the foundation of all tumor diagnostic procedures, the use of radiography, bone scintigraphy and CT is indispensable to ascertain the amount of tissue to be excised. CT competes with B-scan sonography in cervical lymph node diagnostics. Tumor scintigraphy has been found to be an unreliable method.

Aged↗