Biomedical subjects
Publications and source records attributed to G Razinskas.
Three cases of Embolia cutis medicamentosa (Nicolau-Syndrome, E. c. m.) due to intragluteal injection of an antirheumatic containing phenylbutazone are reported. The frequency of various drugs causing Embolia cutis medicamentosa in recent literature is discussed.
The following information was obtained through a control of 76 patients allergic to insect bites who were treated with whole body extract (WBE): The reaction to insect sting was light in 11 patients, intermediate in 31, and severe in 28, while 6 patients developed only extreme local reactions. In 17% of the cases, systemic reactions occurred during skin testing. No statistically significant correlation existed between the severity of the reactions to stings in the patients' history and the skin test results, but such a significant correlation could be found between history of sting reactions and serum antibodies. Hyposensitization, 25% of the patients showed systemic reactions mostly in the first months of therapy. In a posttherapeutic repetition of the skin test with WBE in 40 patients, no statistically significant change in skin sensitivity could be found. Additionally, 27 patients were tested posttherapeutically with venom. No statistical correlation could be found between WBE and venom skin test. 38 patients have been stung at least once since the beginning of therapy. 24 of these (63%) showed no reaction, 10 (26%) developed a weaker reaction by at least one grade, and 4 (10%) reacted just as before therapy. This makes an overall success rate of 90%.
The results of 10 years of patch tests in children with eczema aged between 3 and 16 years are reported. 147 children were tested, of whom 104 (71%) reacted. 334 (6.1%) of 5398 tests were positive and 302 were relevant. 3,539 tests were negative in the 104 children who reacted to at least one substance. 1,525 negative tests were found in 43 children who showed no positive reactions, making a total of 5,064 negative tests among 141 children. The conclusions are: (i) Positive tests are relatively infrequent in children in relation to the large number of tests performed. (ii) The high number of negative results shows that the skin of children can be tested with the concentrations used for adults, and supports the allergic nature of the positive reactions in the series, which were relevant in 90% of the patients.
The results of 10 years of patch testing in children aged 3-16 years are reported. The commonest allergens found were nickel, cobalt, para-dyes and chromate. 26 cases are recorded in detail.