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Biomedical subjects

G Reich

Publications and source records attributed to G Reich.

At least 19 recordsLinked to original sources
PubMed1992

A new peptide of the oxytocin/vasopressin family isolated from nerves of the cephalopod Octopus vulgaris.

An oxytocin/vasopressin-immunoreactive peptide was isolated from nerve terminals of the 'neurosecretory system of the vena cava' in octopus. It was purified by HPLC combined with a RIA for oxytocin. Characterization of the peptide by automated Edman degradation, plasma desorption mass spectroscopy, enzymatic treatment and coelution experiments resulted in the structure: Cys-Tyr-Phe-Arg-Asn-Cys-Pro-Ile-Gly-NH2, a nonapeptide with a molecular weight of 1070 Da and a 1-6 disulfide bond. This cephalopod neuropeptide, here called 'cephalotocin', exhibits 78% sequence homology with the vertebrate neurohypophysial hormone mesotocin and clearly belongs to the oxytocin/vasopressin family of vertebrates, confirming the high conservation of this peptide family.

Amino Acid Sequence↗
PubMed1991

Trace elements and urinary stone formation: new aspects of the pathological mechanism of urinary stone formation.

The urinary stone, serum and 24-hour urine concentrations of 14 trace elements were determined in urinary stone patients by inductively coupled plasma atomic-emission spectroscopy. The data obtained for 25 active stone patients and 32 whose last stone episode had occurred at least 12 months previously were compared with those of 25 healthy individuals. Urinary nickel, manganese and lithium excretion, and serum nickel, manganese and cadmium concentrations were statistically significantly lower for active stone patients compared to those with previous stone episodes and healthy individuals. No difference in the concentrations of trace elements could be found, however, for patients with previous stone episodes and healthy individuals. Nickel, manganese, lithium and cadmium could be of significance in the pathological mechanism of stone formation, not from mineralogical or crystallographic viewpoints but for the smooth flow of enzymatic reactions in biological systems.

Adult↗
PubMed1991

[Interaction pattern in families of children and adolescents with psychosomatic and depressive disorders].

Similarities between depressive and psychosomatic illnesses are described in the literature on a symptomatic, intrapsychic and family dynamics level, differences with regard to the distinctness of aggressive conflict and the delegations of the identified patient, which are more directed to the extra-familiar field in depressive families. In the present study of two families by means of the "Family Interaction Scales" the communication of the "psychosomatic family" seems to be "clearer" than in the "depressive family", the statements are more distinct, less disqualifying, topic changes, spontaneous stands and disagreements are shown more rarely. The intensity of affects is restricted and downed, conflicts and critique are evaded, whereas in the "depressive family" relationships are openly negative. In the "psychosomatic family" clarity and distinctness are achieved by restricted communication. Consequences for further research are discussed.

Adolescent↗
PubMed1989

[Potentials of the interdisciplinary care of children with ectodermal dysplasia].

Children with ectodermal dysplasia represent a group of patients demanding highly sophisticated dental care. Characteristic morphological and functional oral problems lead to special technical difficulties and additionally, the altered psychology of these children requires empathy in treatment. With respect to these problems, children with ectodermal dysplasia are treated in our clinics, multidepartmental cooperation. The interplay between stimulative, restorative and prosthodontic therapy has been shown to be of great benefit for these children.

Child↗
PubMed1987

High density avalanche chamber (HIDAC) positron camera.

A prototype positron camera has been constructed consisting of two high density avalanche chamber (HIDAC) detectors operated in coincidence with a resolving time (2 tau) of 40 nsec. The detectors are multiwire chambers, with specially constructed lead converters added to improve the photon detection efficiency at 511 keV. The current HIDAC detectors have a singles efficiency of approximately 12%, a sensitive area of 31 X 31 cm and an intrinsic spatial resolution of less than 2 mm full width at half maximum (FWHM). During data acquisition, the detectors are rotated around the patient in order to collect a complete angular data set. A three-dimensional image of the positron distribution is reconstructed from a single scan by weighted backprojection of the data into a matrix of either 64 X 64 X 64 or 128 X 128 X 16 voxels. The camera point response function is deconvolved by frequency-space filtering. Corrections are made during backprojection both for photon attenuation and for spatial variations in point source sensitivity. The reconstructed image is further corrected for contributions from accidental and scattered coincidences and displayed as a sequence of two-dimensional transverse, sagittal, or coronal sections. In addition, three-dimensional display is available using shaded graphics techniques. The prototype camera is currently undergoing clinical evaluation.

Bone Neoplasms↗
PubMed1979

Quantitation of the information content of multi-dimensional gas chromatography and low-resolution mass spectrometry in the identification of doping drugs.

On the basis of information theory, a comparison of the performance of the identification of compounds by multi-dimensional gas chromatography and binary-encoded low-resolution mass spectrometry is made for doping drugs. This group of compounds was not selected at random but according to their pharmocological effects. For these compounds it was observed that the m/e values of the peaks in the mass spectra are highly correlated, while a number of chromatographic columns can be found on which the retention data are only slightly correlated. As a result, the information content of two-dimensional gas chromatographic retention data on such columns equals the information content of binary-encoded low-resolution mass spectra. It is shown that the accuracy and precision of retention data in gas--liquid chromatography, and therefore the information content, can be significantly improved if the data are corrected for adsorption effects of the solid support and extrapolated to a limiting value in the case of asymmetric peaks.

Central Nervous System Stimulants↗
PubMed1979

Studies on the quantification of local tissue injury following intramuscular injection of aqueous solutions. VIII. The local lesion after application of turimycin in different preparations.

The increase in drug concentration in aqueous solutions is not responded to by a comparable enlargement of volume of necrosis after intramuscular injection. After application of TURIMYCIN the lesion is more voluminous than those caused by penicillin, lower than those following OTESOLUT and nearly equal to those caused by 5% WOFAPYRIN (phenylbutazone + aminophenazone 1:1).

Animals↗